2008年7月
Attenuation of interferon-gamma mRNA expression in activated Jurkat T cells by exogenous zinc via down-regulation of the calcium-independent PKC-AP-1 signaling pathway
LIFE SCIENCES
- ,
- ,
- ,
- 巻
- 83
- 号
- 1-2
- 開始ページ
- 6
- 終了ページ
- 11
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.lfs.2008.04.022
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Zinc is known to modulate a wide variety of cellular functions including anti-inflammatory responses. We examined the intracellular signaling pathways that contribute to the regulation of interferon-gamma (IFN-gamma) by zinc in activated human Jurkat T cells. Zinc significantly reduced IFN-gamma expression and activator protein-1 (AP-1) signaling in cells activated by phorbol 12-myristate 13-acetate (PMA) and phytohemagglutinin (PHA) without affecting cell viability. Moreover, partial inhibition of AP-1 activity by SP600125, a c-Jun N-terminal kinase (JNK) inhibitor, resulted in marked reduction of IFN-gamma transcription. We also found that this inhibitory effect of zinc on AP-1 signaling was abolished by treatment with rottlerin, a selective inhibitor of calcium-independent protein kinase C (PKC). These results suggest a novel target of zinc in the calcium-independent protein kinase C-AP-1 pathway to regulate endogenous IFN-gamma gene expression in activated T cells. (C) 2008 Elsevier Inc. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.lfs.2008.04.022
- CiNii Articles
- http://ci.nii.ac.jp/naid/80019676789
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/18541274
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000257426100002&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.lfs.2008.04.022
- ISSN : 0024-3205
- CiNii Articles ID : 80019676789
- PubMed ID : 18541274
- Web of Science ID : WOS:000257426100002