MISC

2008年7月

Attenuation of interferon-gamma mRNA expression in activated Jurkat T cells by exogenous zinc via down-regulation of the calcium-independent PKC-AP-1 signaling pathway

LIFE SCIENCES
  • Kumiko Hayashi
  • ,
  • Satoshi Ishizuka
  • ,
  • Chieko Yokoyama
  • ,
  • Toshihisa Hatae

83
1-2
開始ページ
6
終了ページ
11
記述言語
英語
掲載種別
DOI
10.1016/j.lfs.2008.04.022
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Zinc is known to modulate a wide variety of cellular functions including anti-inflammatory responses. We examined the intracellular signaling pathways that contribute to the regulation of interferon-gamma (IFN-gamma) by zinc in activated human Jurkat T cells. Zinc significantly reduced IFN-gamma expression and activator protein-1 (AP-1) signaling in cells activated by phorbol 12-myristate 13-acetate (PMA) and phytohemagglutinin (PHA) without affecting cell viability. Moreover, partial inhibition of AP-1 activity by SP600125, a c-Jun N-terminal kinase (JNK) inhibitor, resulted in marked reduction of IFN-gamma transcription. We also found that this inhibitory effect of zinc on AP-1 signaling was abolished by treatment with rottlerin, a selective inhibitor of calcium-independent protein kinase C (PKC). These results suggest a novel target of zinc in the calcium-independent protein kinase C-AP-1 pathway to regulate endogenous IFN-gamma gene expression in activated T cells. (C) 2008 Elsevier Inc. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.lfs.2008.04.022
CiNii Articles
http://ci.nii.ac.jp/naid/80019676789
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18541274
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000257426100002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.lfs.2008.04.022
  • ISSN : 0024-3205
  • CiNii Articles ID : 80019676789
  • PubMed ID : 18541274
  • Web of Science ID : WOS:000257426100002

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