論文

査読有り
2017年7月

Irinotecan monotherapy as third-line treatment for advanced gastric cancer refractory to fluoropyrimidines, platinum, and taxanes

GASTRIC CANCER
  • Takashi Nishimura
  • ,
  • Satoru Iwasa
  • ,
  • Kengo Nagashima
  • ,
  • Natsuko Okita
  • ,
  • Atsuo Takashima
  • ,
  • Yoshitaka Honma
  • ,
  • Ken Kato
  • ,
  • Tetsuya Hamaguchi
  • ,
  • Yasuhide Yamada
  • ,
  • Yasuhiro Shimada
  • ,
  • Narikazu Boku

20
4
開始ページ
655
終了ページ
662
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10120-016-0670-9
出版者・発行元
SPRINGER

Because standard chemotherapy for advanced gastric cancer consists of oral fluoropyrimidines plus platinum as first-line therapy, with paclitaxel plus ramucirumab as the second line, irinotecan is usually positioned as third-line chemotherapy in clinical practice in Japan.A retrospective evaluation was conducted to determine the efficacy and safety of irinotecan as third-line chemotherapy for advanced gastric cancer in patients refractory or intolerant to fluoropyrimidines, platinum, and taxanes.Between February 2008 and December 2013, 52 patients received third-line irinotecan monotherapy. Among the 32 patients with measurable lesions, 1 patient achieved a confirmed partial response and 6 patients had stable disease. The overall response rate was 3% and the disease control rate was 22%. Median progression-free survival was 2.3 months [95% confidence interval (CI), 1.8-2.8] and median overall survival was 4.0 months (95% CI, 2.6-5.3). The most common adverse events of grade 3 severity or higher were neutropenia (27%), febrile neutropenia (12%), anorexia (12%), and diarrhea (6%). Although no treatment-related deaths occurred, 2 patients (4%) died of disease progression within 30 days after the last administration of irinotecan.Irinotecan monotherapy appears to be tolerated but was shown to have modest activity as third-line chemotherapy for advanced gastric cancer.

Web of Science ® 被引用回数 : 19

リンク情報
DOI
https://doi.org/10.1007/s10120-016-0670-9
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000404225400011&DestApp=WOS_CPL

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