論文

査読有り
2017年9月

Validation of the JCOG prognostic index in advanced gastric cancer using individual patient data from the SPIRITS and G-SOX trials

GASTRIC CANCER
  • Daisuke Takahari
  • ,
  • Junki Mizusawa
  • ,
  • Wasaburo Koizumi
  • ,
  • Ichinosuke Hyodo
  • ,
  • Narikazu Boku

20
5
開始ページ
757
終了ページ
763
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10120-017-0702-0
出版者・発行元
SPRINGER

Background In a phase III study for advanced gastric cancer (AGC), the Japan Clinical Oncology Group (JCOG) 9912 trial, we previously identified the following four prognostic factors-performance status >= 1, number of metastatic sites >= 2, no prior gastrectomy, and abnormal serum alkaline phosphatase levels-and proposed a prognostic index (good risk with 0 or 1 factor, moderate risk with 2 or 3 factors, and poor risk with all 4 factors). To assess the generalizability of this index, we attempted an external validation study using an independent data set.
Methods Individual patient data from the SPIRITS and G-SOX trials were applied to the JCOG prognostic index. The accuracy of the index for predicting survival was assessed by the Cox proportional hazards model.
Results The available data were obtained from 936 (94.5%) of the 990 patients in these trials. The three risk groups categorized by the JCOG prognostic index demonstrated highly significant survival differences; the hazard ratios (95% confidence interval) were 1.71 (1.46-2.01) between the good (n = 338) and moderate (n = 537) risk groups and 3.32 (2.47-4.46) between good and poor (n = 61) risk groups. The median overall survival times of the good, moderate, and poor risk groups were 17.2, 12.0, and 7.8 months, respectively.
Conclusions The JCOG prognostic index was externally validated and can be widely utilized for clinical trials. Further studies are needed to apply this index to the Western population.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1007/s10120-017-0702-0
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000408084000001&DestApp=WOS_CPL

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