論文

査読有り
2017年9月

Efficacy and safety of taxane monotherapy in advanced gastric cancer refractory to triplet chemotherapy with docetaxel, cisplatin, and S-1: a multicenter retrospective study

CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Sakura Iizumi
  • ,
  • Atsuo Takashima
  • ,
  • Yukiya Narita
  • ,
  • Masahiro Tajika
  • ,
  • Kei Muro
  • ,
  • Sadayuki Kawai
  • ,
  • Hirofumi Yasui
  • ,
  • Tomohiro Matsushima
  • ,
  • Daisuke Takahari
  • ,
  • Kengo Nagashima
  • ,
  • Narikazu Boku

80
3
開始ページ
575
終了ページ
582
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00280-017-3397-3
出版者・発行元
SPRINGER

Taxane monotherapy is widely used for advanced gastric cancer (AGC) after failure of standard first-line chemotherapy with fluoropyrimidine and cisplatin. Triplet chemotherapy with docetaxel, cisplatin, and S-1 (DCS) is a promising regimen for first-line chemotherapy of AGC. The aim of this study was to evaluate the efficacy of taxane monotherapy in patients refractory to DCS.
We retrospectively evaluated the efficacy and safety of taxane monotherapy in patients with AGC refractory to first-line therapy with DCS between January 2010 and April 2015. Selection criteria were as follows: ECOG PS of 0-2, treatment with taxane monotherapy in second-line or third-line therapy after failure of second-line irinotecan, absence of massive ascites, and adequate organ function.
A total of 30 patients were included in this study. Of these, 15 patients received paclitaxel while another 15 received nanoparticle albumin-bound paclitaxel in either second- or third-line treatment. Median age for the second/third-line group was 64.0/62.0 (range 27-75/42-75); 14/13 (93.3/86.7%) had ECOG PS of 0 or 1. No patients achieved complete or partial response and stable disease was observed in 37.5/35.7% of the patients in the second/third line. Median progression-free survival and overall survival were 3.4 and 5.8 months in the second-line group, and 2.0 and 4.5 months in the third-line group, respectively. The incidences of any grade ae<yen>3 adverse events in the second-line group and the third-line group were 60.0 and 33.3%, respectively. There was no treatment-related death.
Taxane monotherapy after DCS failure had acceptable toxicities but was ineffective in AGC patients.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1007/s00280-017-3397-3
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000408616700015&DestApp=WOS_CPL

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