2016年11月
Perivascular epithelioid cell tumor of the descending colon mimicking a gastrointestinal stromal tumor: a case report
WORLD JOURNAL OF SURGICAL ONCOLOGY
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- 巻
- 14
- 号
- 1
- 開始ページ
- 285
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1186/s12957-016-1046-7
- 出版者・発行元
- BIOMED CENTRAL LTD
Background: We present a case of perivascular epithelioid cell tumor (PEComa), which clinically and histologically mimics a gastrointestinal stromal tumor (GIST).
Case presentation: A 42-year-old woman was found to have a mass in the left flank during her annual medical checkup. Computed tomography examination revealed a submucosal tumor of the descending colon. Surgeons and radiologists suspected that the lesion was a GIST, and left hemicolectomy was performed without biopsy. Microscopic examination showed that the lesion was composed of spindle and epithelioid cells, which were immunohistochemically negative for c-kit and positive for platelet-derived growth factor receptor (PDGFR) a. Initial diagnosis of PDGFR alpha-positive GIST was made. However, gene analysis did not reveal mutations in PDGFR alpha. Additional immunohistochemistry showed that tumor cells were positive for human melanin black 45 (HMB45), melanA, and the myogenic marker calponin. A final diagnosis of PEComa was made.
Conclusion: PEComa should be included in the differential diagnosis of PDGFR alpha-positive spindle cell tumors in the wall of the gastrointestinal tract.
Case presentation: A 42-year-old woman was found to have a mass in the left flank during her annual medical checkup. Computed tomography examination revealed a submucosal tumor of the descending colon. Surgeons and radiologists suspected that the lesion was a GIST, and left hemicolectomy was performed without biopsy. Microscopic examination showed that the lesion was composed of spindle and epithelioid cells, which were immunohistochemically negative for c-kit and positive for platelet-derived growth factor receptor (PDGFR) a. Initial diagnosis of PDGFR alpha-positive GIST was made. However, gene analysis did not reveal mutations in PDGFR alpha. Additional immunohistochemistry showed that tumor cells were positive for human melanin black 45 (HMB45), melanA, and the myogenic marker calponin. A final diagnosis of PEComa was made.
Conclusion: PEComa should be included in the differential diagnosis of PDGFR alpha-positive spindle cell tumors in the wall of the gastrointestinal tract.
- リンク情報
- ID情報
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- DOI : 10.1186/s12957-016-1046-7
- ISSN : 1477-7819
- PubMed ID : 27842558
- Web of Science ID : WOS:000388134800002