論文

査読有り
2014年

Interferon-γ/CCR5 expression in invariant natural killer T cells and CCL5 expression in capillary veins of dermal papillae correlate with development of psoriasis vulgaris

British Journal of Dermatology
  • F. Kono
  • ,
  • T. Honda
  • ,
  • W. Aini
  • ,
  • T. Manabe
  • ,
  • H. Haga
  • ,
  • T. Tsuruyama

170
5
開始ページ
1048
終了ページ
1055
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/bjd.12812
出版者・発行元
Blackwell Publishing Ltd

Background There have been extensive studies regarding which types of T lymphocytes are involved in psoriasis vulgaris (PV). However, it has remained unclear which types of T lymphocytes might directly contribute to psoriasiform epidermal and vascular hyperplasia. Objectives To understand the role of T-cell receptor (TCR)Vα24+ invariant natural killer (iNK)T cells in the development of PV. Methods Seventeen patients were enrolled in this study. Using biopsy samples of PV plaques, TCRVα24+ iNKT cells were investigated regarding their cytokine production to understand their roles in development of disease. Results The number of interferon (IFN)-γ+ iNKT cells correlated with the length of the psoriasiform hyperplasia rete ridge and the Psoriasis Area and Severity Index. IFN-γ+ iNKT cells in psoriatic skin exhibited higher C-C chemokine receptor (CCR)5 expression, and the amount of C-C chemokine ligand (CCL)5, a ligand for CCR5, was increased in capillary veins of psoriasis plaques. CCR5+ iNKT-cell numbers significantly correlated with the number of capillary vein endothelial cells expressing CCL5 in PV. Furthermore, the number of CCL5+ capillary veins correlated with the maximum rete ridge length. Conclusions IFN-γ/CCR5 expression in iNKT cells and CCL5 expression in vessels of dermal papillae correlate with the development of psoriasiform hyperplasia and microabscess. We propose that these iNKT cells may become useful targets for development of novel therapeutic approaches to PV. What's already known about this topic? Natural killer (NK)T cells are present in psoriasis plaques, and injection of NKT cells into transplanted psoriatic skin drives lesion formation. Imbalance of interferon (IFN)-γ and interleukin (IL)-4 contributes to lesion development. Injection of IL-4 into the plaque ameliorates psoriasis. What does this study add? Invariant NK (iNK)T-cell number correlates with the length of the rete ridge, and with the Psoriasis Area and Severity Index, epidermal hyperplasia and degree of microabscess formation. iNKT cells in psoriatic skin have higher CCR5 expression, and the CCR5+ iNKT-cell count correlates with that of CCL5+ capillaries in dermal papillae. The CCL5+ capillary endothelial cell count correlates with epidermal hyperplasia. © 2013 British Association of Dermatologists.

リンク情報
DOI
https://doi.org/10.1111/bjd.12812
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24372073
ID情報
  • DOI : 10.1111/bjd.12812
  • ISSN : 1365-2133
  • ISSN : 0007-0963
  • PubMed ID : 24372073
  • SCOPUS ID : 84901020049

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