論文

査読有り
2010年3月

Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement

PATHOLOGY INTERNATIONAL
  • Yasuni Nakanuma
  • Yoh Zen
  • Kenichi Harada
  • Motoko Sasaki
  • Akitaka Nonomura
  • Takeshi Uehara
  • Kenji Sano
  • Fukuo Kondo
  • Toshio Fukusato
  • Koichi Tsuneyama
  • Masahiro Ito
  • Kenichi Wakasa
  • Minoru Nomoto
  • Hiroshi Minato
  • Hironori Haga
  • Masayoshi Kage
  • Hirohisa Yano
  • Joji Haratake
  • Shinichi Aishima
  • Tomoyuki Masuda
  • Hajime Aoyama
  • Aya Miyakawa-Hayashino
  • Toshiharu Matsumoto
  • Hayato Sanefuji
  • Hidenori Ojima
  • Tse-Ching Chen
  • Eunsil Yu
  • Ji-Hun Kim
  • Young Nyun Park
  • Wilson Tsui
  • 全て表示

60
3
開始ページ
167
終了ページ
174
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1440-1827.2009.02500.x
出版者・発行元
WILEY-BLACKWELL PUBLISHING, INC

Recently the authors proposed a new staging and grading system for primary biliary cirrhosis (PBC) that takes into account necroinflammatory activity and histological heterogeneity. Herein is proposed a convenient version of this system. Scores for fibrosis, bile duct loss, and chronic cholestasis were combined for staging: stage 1, total score of 0; stage 2, score 1-3; stage 3, score 4-6; and stage 4, score 7-9. Cholangitis activity (CA) and hepatitis activity (HA) were graded as CA0-3, and HA0-3, respectively. Analysis of interobserver agreement was then conducted. Digital images of 62 needle liver biopsy specimens of PBC were recorded as virtual slides on DVDs that were sent to 28 pathologists, including five located overseas. All participants were able to apply this version in all 62 cases. For staging, kappa was 0.385 (fair agreement) and the concordance rate was 63.9%. For necroinflammatory activity, the kappa and concordance rate were 0.110 (slight agreement) and 36.9% for CA, and 0.197 (slight agreement) and 47% for HA, respectively. In conclusion, this new staging and grading system for PBC seems to be more convenient and practical than those used at present, but more instruction and guidance are recommended for the grading of necroinflammatory activity in practice.

リンク情報
DOI
https://doi.org/10.1111/j.1440-1827.2009.02500.x
J-GLOBAL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201002245188538733
CiNii Articles
http://ci.nii.ac.jp/naid/10029330966
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20403042
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000274906800003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1440-1827.2009.02500.x
  • ISSN : 1320-5463
  • J-Global ID : 201002245188538733
  • CiNii Articles ID : 10029330966
  • PubMed ID : 20403042
  • Web of Science ID : WOS:000274906800003

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