2013年
Carbonic anhydrase type IX expression in lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix
PATHOLOGY RESEARCH AND PRACTICE
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- 巻
- 209
- 号
- 3
- 開始ページ
- 173
- 終了ページ
- 178
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.prp.2012.12.003
- 出版者・発行元
- ELSEVIER GMBH, URBAN & FISCHER VERLAG
The significance of carbonic anhydrase (CA-IX) expression in endocervical glandular lesions was determined to assess the utility of CA-IX immunohistochemistry for the identification of gastric-type endocervical adenocarcinoma and its related lesions. In this study, lobular endocervical glandular hyperplasia (LEGH) (n = 5), atypical LEGH (ALEGH) (n = 6), and endocervical adenocarcinomas, including usual-type (UEA) (n = 6) and gastric-type (GAS) (n = 7), were examined by immunohistochemistry for CA-IX expression. The proportion of positive staining and intensity was evaluated as between 0 and 3+. All 13 UEAs and GASs were positive for CA-IX, with 9 cases showing 3+ staining, and 8 cases showing positive areas exceeding 50%. All 11 LEGHs were positive for CA-IX, with all cases showing 50% or more positive areas, although only one case was 3+ positive. Five of 6 ALEGHs were positive for CA-IX, with 4 cases showing 3+ positivity in 100% of the lesion. Non-neoplastic glands were negative for CA-IX, although reserve cell populations and tubal metaplasias were positive for CA-IX. Although CA-IX appears to be involved in tumor progression and may be diagnostically useful in cases of endocervical adenocarcinoma and its precursors, LEGH can be a pitfall, and staining results should be combined with morphology. (C) 2013 Elsevier GmbH. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.prp.2012.12.003
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201302246591140144
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/23391777
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000317093000007&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.prp.2012.12.003
- ISSN : 0344-0338
- J-Global ID : 201302246591140144
- PubMed ID : 23391777
- Web of Science ID : WOS:000317093000007