Sep, 2009
Evaluation of the measurement of serum cystatin C by an enzyme-linked immunosorbent assay for humans as a marker of the glomerular filtration rate in dogs.
The Journal of veterinary medical science
- ,
- ,
- Volume
- 71
- Number
- 9
- First page
- 1169
- Last page
- 76
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1292/jvms.71.1169
- Publisher
- JAPAN SOC VET SCI
The serum cystatin C (Cys-C) concentration is a better filtration marker than plasma creatinine (Cre) concentration in humans. In veterinary medicine, a few studies have shown that the serum Cys-C concentration in dogs is also a better marker than the plasma Cre concentration. The purpose of this study is to evaluate the applicability of measuring the serum Cys-C concentration by an enzyme-linked immunosorbent assay (ELISA) as a marker of the glomerular filtration rate in dogs with various renal dysfunctions. The serum Cys-C concentration in dogs with chronic kidney disease (CKD) was significantly higher (1.23 +/- 0.21 mg/L) than that in 76 control dogs (0.85 +/- 0.15) (P<0.001). The reference range of the serum Cys-C concentrations in samples from the 76 control dogs was 0.55-1.15 mg/l. Serum Cys-C concentration was more strongly correlated with plasma iohexol clearance (r=-0.704, P<0.001) than plasma Cre concentration in dogs (r=-0.598, P<0.001). In a receiver operating characteristics analysis, significant differences between the serum Cys-C and plasma Cre concentrations were found with regard to their AUC (0.949, [SE, 0.019] and 0.849 [SE, 0.029]) and diagnostic sensitivity (90.3% and 73.6%) for detecting decreased PCio (P<0.05). Therefore, the measurement of serum Cys-C concentration by ELISA is more useful for the detection of early CKD than measuring the plasma Cre concentration.
- Link information
-
- DOI
- https://doi.org/10.1292/jvms.71.1169
- J-GLOBAL
- https://jglobal.jst.go.jp/en/detail?JGLOBAL_ID=200902295125972472
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/19801896
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000271050300004&DestApp=WOS_CPL
- ID information
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- DOI : 10.1292/jvms.71.1169
- ISSN : 0916-7250
- J-Global ID : 200902295125972472
- Pubmed ID : 19801896
- Web of Science ID : WOS:000271050300004