Papers

Peer-reviewed
8 2013

Relationship between glomerular filtration rate and plasma N-terminal pro B-type natriuretic peptide concentrations in dogs with chronic kidney disease

VETERINARY JOURNAL
  • Y. Miyagawa
  • ,
  • Y. Tominaga
  • ,
  • N. Toda
  • ,
  • N. Takemura

Volume
197
Number
2
First page
445
Last page
450
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/j.tvjl.2013.02.016
Publisher
ELSEVIER SCI LTD

Plasma N-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations increase in dogs with azotemia. However, the correlation between glomerular filtration rate (GFR) and NT-proBNP concentrations in dogs has not been evaluated. The objective of this study was to evaluate the correlation between GFR and plasma NT-proBNP concentrations in dogs with chronic kidney disease (CKD). In this retrospective cross-sectional study, plasma creatinine (Cre) and NT-proBNP concentrations, plasma iohexol clearance (PCio) values and blood pressure were measured in dogs with CKD. Dogs were classified according to PCio values into D group (dogs with decreased PCio values), and N group (dogs with normal PCio values). Dogs were further categorized on the basis of their systolic blood pressure and PCio values into NT-D group (normotensive dogs with decreased PCio values), NT-N group (normotensive dogs with normal PCio values), HT-D group (hypertensive dogs with decreased PCio values) and HT-N group (hypertensive dogs with normal PCio values).
Significant correlations were observed between plasma NT-proBNP and Cre concentrations (r = 0.360, P < 0.05) and PCio values (r = 0.470, P < 0.01). Plasma NT-proBNP concentrations were significantly higher in the D group than in the N group (P < 0.001). Plasma NT-proBNP concentrations were significantly higher in the HT-D group than in the other three groups (P <= 0.007). No differences in plasma NT-proBNP concentrations were observed between the NT-D and HT-N groups (P = 0.28). Plasma NT-proBNp concentrations were significantly lower in the NT-N group than in the other three groups (P 0043). Our findings suggest that decreased GFR might be associated with increased plasma NT-proBNP concentrations in dogs, similar to that in humans. In addition, the complication of hypertension in CKD might be associated with further increases in plasma NT-proBNP concentrations. In conclusion, the effects of GFR and blood pressure on the plasma NT-proBNP concentration were small, but it could be necessary to consider the effects when this marker is used to evaluate canine cardiac disease. (C) 2013 Elsevier Ltd. All rights reserved.

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Link information
DOI
https://doi.org/10.1016/j.tvjl.2013.02.016
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23570775
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000324665400058&DestApp=WOS_CPL

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