Papers

Peer-reviewed
7 2016

Comparison of the effects of long-term pimobendan and benazepril administration in normal cats

JOURNAL OF VETERINARY MEDICAL SCIENCE
  • Yuichi Miyagawa
  • ,
  • Noboru Machida
  • ,
  • Noriko Toda
  • ,
  • Yoshinori Tominaga
  • ,
  • Naoyuki Takemura

Volume
78
Number
7
First page
1099
Last page
1106
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1292/jvms.14-0673
Publisher
JAPAN SOC VET SCI

Pimobendan (PIMO) can cause adverse effects, such as mitral valve degeneration, in dogs; however, it is unclear whether these effects occur in cats. Therefore, we aimed to determine whether PIMO or benazepril produces adverse cardiac effects in healthy cats. This was a blinded, randomized, prospective parallel study. Twelve cats were randomly divided into two groups of six cats, namely, an angiotensin-converting-enzyme inhibitor group that received benazepril and a PIMO group. Cats were administered their respective treatments for 506 days, and we evaluated cardiac parameters, blood biochemistry and glomerular filtration rates during that time. At the end of the trial, the cats were euthanized, and histopathological examinations were performed by a pathologist who was blinded to the treatment groups. No significant changes were observed in any of the parameters measured in either of the groups. In particular, no significant cardiac lesions were observed in either of the groups. In healthy cats, neither PIMO nor benazepril appears to cause cardiac lesions, but future studies are needed to examine the effects of PIMO in cats with heart disease.

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Link information
DOI
https://doi.org/10.1292/jvms.14-0673
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26972332
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000380622000002&DestApp=WOS_CPL

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