2016年
Non-24-hour sleep-wake syndrome improved by low-dose valproic acid: a case report
NEUROPSYCHIATRIC DISEASE AND TREATMENT
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- 巻
- 12
- 号
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2147/NDT.S115648
- 出版者・発行元
- DOVE MEDICAL PRESS LTD
A woman was diagnosed with non-24-hour sleep-wake syndrome and depressive symptoms. Her depressive symptoms did not respond to standard doses of several antidepressants or mood stabilizers. Furthermore, her sleep-wake cycle remained non-entrained despite treatment with a melatonin-related drug, vitamin B12, and phototherapy. Ultimately, her sleep-wake rhythm was restored to a 24-hour pattern with a low dose of valproic acid, and her depressive symptoms tended to improve as a result of synchronization without antidepressants. Low-dose valproic acid appears to be one of the effective means of entraining circadian rhythms in patients with non-24- hour sleep-wake syndrome, which in turn likely improves associated depressive symptoms.
- リンク情報
- ID情報
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- DOI : 10.2147/NDT.S115648
- ISSN : 1178-2021
- Web of Science ID : WOS:000389791700001