2008年11月
Dendritic cells and macrophages in the genitourinary tract
MUCOSAL IMMUNOLOGY
- ,
- ,
- 巻
- 1
- 号
- 6
- 開始ページ
- 451
- 終了ページ
- 459
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/mi.2008.57
- 出版者・発行元
- NATURE PUBLISHING GROUP
Dendritic cells (DCs) and macrophages are antigen-presenting cells (APCs) that are important in innate immune defense as well as in the generation and regulation of adaptive immunity against a wide array of pathogens. The genitourinary (GU) tract, which serves an important reproductive function, is constantly exposed to numerous agents of sexually transmitted infections (STIs). To combat these STIs, several subsets of DCs and macrophages are strategically localized within the GU tract. In the female genital mucosa, recruitment and function of these APCs are uniquely governed by sex hormones. This review summarizes the latest advances in our understanding of DCs and macrophages in the GU tract with respect to their subsets, lineage, and function. In addition, we discuss the divergent roles of these cells in immune defense against STIs as well as in maternal tolerance to the fetus.
- リンク情報
- ID情報
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- DOI : 10.1038/mi.2008.57
- ISSN : 1933-0219
- PubMed ID : 19079212
- Web of Science ID : WOS:000260471300006