Hirotada Otsuka

Profile Information

Affiliation: Associate Professor (PhD), Laboratory of Veterinary Anatomy, Nippon Veterinary and Life Science University

J-GLOBAL ID: 201701017544609751
researchmap Member ID: B000285933

Research Areas

Research History

Apr, 2022 - Present

(PhD), Laboratory of Veterinary Anatomy, Nippon Veterinary and Life Science University
Nov, 2017 - Present

Nippon Veterinary and Life Science University
Apr, 2012 - Oct, 2017

School of Dentistry, Oral Anatomy, Showa University
Apr, 2008 - Mar, 2012

Guraduate School, Showa University
Apr, 2005 - Mar, 2008

Ministry of Agriculture, Forestry and Fisheries

Awards

May, 2018

上條奨学賞研究部門, 窒素含有型ビスホスホネートを用いた重症貧血マウスモデルの確立及び同モデルにおける造血動態の解析, 昭和大学

大塚裕忠

Papers

Histamine deficiency inhibits lymphocyte infiltration in the submandibular gland of aged mice via increased anti-aging factor Klotho.

Hirotada Otsuka, Naoko Nonaka, Masanori Nakamura, Satoshi Soeta

Journal of oral biosciences, Jun 19, 2023
Expression of type VI collagen α3 chain in canine mammary carcinomas

Mami Araki, Syunya Noguchi, Yoshiaki Kubo, Akiko Yasuda, Miki Koh, Hirotada Otsuka, Makoto Yokosuka, Satoshi Soeta

Research in Veterinary Science, Apr, 2023
Expression of receptor-type tumour endothelial marker 8 in carcinoma cells showing luminal progenitor-like phenotypes in canine mammary gland carcinomas

Mami Araki, Syunya Noguchi, Yoshiaki Kubo, Akiko Yasuda, Miki Koh, Hirotada Otsuka, Makoto Yokosuka, Satoshi Soeta

Journal of Comparative Pathology, 200 35-45, Jan, 2023
Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments.

Hirotada Otsuka, Yasuo Endo, Hiroshi Ohtsu, Satoshi Inoue, Syunya Noguchi, Masanori Nakamura, Satoshi Soeta

International journal of hematology, 113(3) 348-361, Jan 4, 2021 Peer-reviewedLead author
Changes in histidine decarboxylase expression influence extramedullary hematopoiesis in postnatal mice.

Hirotada Otsuka, Yasuo Endo, Hiroshi Ohtsu, Satoshi Inoue, Mutsuki Kuraoka, Miki Koh, Hideki Yagi, Masanori Nakamura, Satoshi Soeta

Anatomical record (Hoboken, N.J. : 2007), 304(5) 1136-1150, Oct 9, 2020 Peer-reviewedLead author
Big Insulin-like Growth Factor 2-Producing Tumor in a Hypoglycemic Dog.

Syunya Noguchi, Yoshiaki Kubo, Mami Araki, Miki Koh, Yuji Hamamoto, Kyoichi Tamura, Hirotada Otsuka, Akiko Yasuda, Daigo Azakami, Masaki Michishita …

Veterinary pathology, 57(3) 432-436, May, 2020 Peer-reviewed
Expression of Tumour Endothelial Marker 8 in Canine Mammary Gland Tumour Cells.

S Noguchi, M Araki, K Nakajima, M Koh, Y Kokado, Y Kubo, H Otsuka, A Yasuda, M Yokosuka, S Soeta

Journal of comparative pathology, 173 30-40, Nov, 2019 Peer-reviewed
Dynamics of Platelet Behaviors as Defenders and Guardians: Accumulations in Liver, Lung, and Spleen in Mice.

Zhiqian Yu, Masahiro Shibazaki, Hirotada Otsuka, Haruhiko Takada, Masanori Nakamura, Yasuo Endo

Biological & pharmaceutical bulletin, 42(8) 1253-1267, 2019 Peer-reviewed
Decisive differences in the bone repair processes of the metaphysis and diaphysis in young mice

Satoshi Inoue, Hirotada Otsuka, Jiro Takito, Masanori Nakamura

Bone Reports, 8 1-8, Jun 1, 2018 Peer-reviewed
Symmetrical retrograde actin flow in the actin fusion structure is involved in osteoclast fusion

Jiro Takito, Hirotada Otsuka, Satoshi Inoue, Tsubasa Kawashima, Masanori Nakamura

BIOLOGY OPEN, 6(7) 1104-1114, Jul, 2017 Peer-reviewed
Histological identification of cells directly participating calcified tissue resorption and destruction

Masanori Nakamura, Hirotada Otsuka

FASEB JOURNAL, 31, Apr, 2017 Peer-reviewed
Nitrogen-containing bisphosphonate induces a newly discovered hematopoietic structure in the omentum of an anemic mouse model by stimulating G-CSF production

Hirotada Otsuka, Hideki Yagi, Yasuo Endo, Satoshi Soeta, Naoko Nonaka, Masanori Nakamura

CELL AND TISSUE RESEARCH, 367(2) 297-309, Feb, 2017 Peer-reviewedLead author
Pulmonary platelet accumulation induced by catecholamines: Its involvement in lipopolysaccharide-induced anaphylaxis-like shock

Zhiqian Yu, Hiroko Saito, Hirotada Otsuka, Yosuke Shikama, Hiromi Funayama, Mai Sakai, Shigeo Murai, Masanori Nakamura, Takashi Yokochi, Haruhiko Takada …

INTERNATIONAL IMMUNOPHARMACOLOGY, 43 40-52, Feb, 2017 Peer-reviewed
0

New Experimental Anemic Model by Using a Nitrogen- Containing Bisphosphonate

Otsuka Hirotada Soeta Satoshi, Yagi Hideki, Endo Yasuo, Nakamura Masanori

Annals of Nutritional Disorders & Therapy, 4(2) 1043-1047, 2017 Peer-reviewedLead author
Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing.

Tetsutaro Yamaguchi, Kazuyoshi Hosomichi, Keisuke Yano, Yong-Il Kim, Hirofumi Nakaoka, Ryosuke Kimura, Hirotada Otsuka, Naoko Nonaka, Shugo Haga, Masahiro Takahashi …

Human genome variation, 4 17005-17005, 2017 Peer-reviewed
0

Effect of minodronate, a nitrogen-containing bisphosphonates, on collagen-induced arthritis model mice

Hiroshi Arai, Hirotada Otsuka, Jiro Takito, Hideki Yagi, Satoshi Inoue, Nobuaki Yanagisawa, Naoko Nonaka, Yasuo Endo Masanori Nakamura

Cellular Immunology & Immunotherapeutics, 1(1) 1-7, 2016 Peer-reviewed
The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate

Hirotada Otsuka, Jiro Takito, Yasuo Endo, Hideki Yagi, Satoshi Soeta, Nobuaki Yanagisawa, Naoko Nonaka, Masanori Nakamura

BMC Hematology, 16(1) 4, 2016 Peer-reviewedLead author
Analysis of periapical alveolar bone resorption after the removal of interdental wire ligation

Kubono, Yoshino, Mayahara, Mitsuori, Otsuka, Hirotada, Kataoka, Ryuta, Takagi, Yoshitoki, Asari, Jin, Nonaka, Naoko, Inoue, Mitsuko, Nakamura, Masanori

PEDIATRIC DENTAL JOURNAL, 25(1) 1-7, Apr, 2015 Peer-reviewed
Regulation of Osteoclast Multinucleation by the Actin Cytoskeleton Signaling Network

Jiro Takito, Hirotada Otsuka, Nobuaki Yanagisawa, Hiroshi Arai, Masayasu Shiga, Mitsuko Inoue, Naoko Nonaka, Masanori Nakamura

JOURNAL OF CELLULAR PHYSIOLOGY, 230(2) 395-405, Feb, 2015 Peer-reviewed
The functional diversity of kupffer cells

Nakamura M, Otsuka H, Yagi H, Endo Y

Handbook of Macrophages: Life Cycle, Functions and Diseases, 329-344, 2012 Peer-reviewed

Misc.

過酸化様態グリセリンを元に調整した固定液の肉眼解剖実習用標本および組織標本作製における有用性

黄美貴, 倉岡睦季, 大塚裕忠, 添田聡, 尼崎肇

日本獣医学会学術集会講演要旨集, 166th, 2023
Expressions of vascular endothelial growth factor receptors, Flk1 and Flt1, in rat skin mast cells during development.

Miki Koh, Syunya Noguchi, Mami Araki, Hirotada Otsuka, Makoto Yokosuka, Satoshi Soeta

The Journal of veterinary medical science, 82(6) 745-753, Jun 24, 2020 Peer-reviewed
【口腔環境と全身のクロストーク】造血組織と骨、ビスフォスフォネートの関与

中村雅典, 八木秀樹, 大塚裕忠, 遠藤康男

炎症と免疫, 27(6) 463-468, Oct, 2019 Peer-reviewedInvited
造血組織と骨、ビスフォスフォネートの関与

中村雅典, 八木秀樹, 大塚裕忠, 遠藤康男

炎症と免疫, 27(6) 19-24, 2019
ヒスタミン欠損マウスにおける造血・リンパ性器官の形態学的研究

大塚裕忠, 大塚裕忠, 角山優輔, 遠藤康男, 大津浩, 大津浩, 中村雅典, 添田聡

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 124th 148, 2019
Functional and morphological analysis of newly inclued hematopoietic organs in anemic mouse

50(9) 496-500, Aug, 2018
マウス創傷治癒過程における局所的マクロファージ除去の影響

藤川芳織, 井上知, 瀧戸次郎, 大塚裕忠, 中村雅典

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 123rd 159, 2018
2つの異なる扁平骨における骨修復過程の解析

井上知, 藤川芳織, 大塚裕忠, 中村雅典

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 123rd 179, 2018
髄外造血誘導におけるHistidine decarboxylaseの役割に関する研究

大塚裕忠, 添田聡, 大津浩, 大津浩, 尼崎肇, 中村雅典

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 123rd 165, 2018
The Establishment of a Severely Anemic Mouse Model Induced by Nitrogen-containing Bisphosphonate and the Study of Hematopoietic Systems in the Model

大塚裕忠, 大塚裕忠

Journal of The Showa University Society, 78(6) 636-641, 2018
新規造血構造の機能形態学的特性

大塚裕忠, 中村雅典

月刊細胞, 49(4) 203‐207, Apr 20, 2017
Functional and morphological analysis of newly include hematopoietic organs in anemic mouse

大塚裕忠, 中村雅典

細胞, 49(4) 203-207, Apr, 2017
骨幹端における骨損傷の修復過程は骨幹部と異なる

井上知, 大塚裕忠, 瀧戸二郎, 柳澤伸彰, 野中直子, 中村雅典

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 122nd 140, 2017
長骨骨幹端領域における骨修復機構

井上知, 大塚裕忠, 中村雅典

Journal of Oral Biosciences Supplement (Web), 2017 ROMBUNNO.P1‐5 (WEB ONLY), 2017
重症貧血マウスモデルの大網組織における造血関連因子の解析

大塚裕忠, 中村雅典

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 122nd 192, 2017
長骨骨幹部および骨幹端における骨修復機構の比較(学位甲)

井上知, 大塚裕忠, 瀧戸次郎, 柳澤伸彰, 野中直子, 中村雅典

昭和学士会雑誌, 76(4) 551-551, Aug, 2016
窒素含有型ビスホスホネートを用いた重症貧血マウスモデルにおける新規造血構造誘導機構の解析

大塚裕忠, 中村雅典

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 121st 130, 2016
長骨骨幹部および骨幹端における骨修復機構の比較

井上知, 大塚裕忠, 瀧戸次郎, 柳澤伸彰, 野中直子, 中村雅典

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 121st 134, 2016
ミノドロネート投与によるコラーゲン誘導型関節炎モデルマウスへの影響

新井宏, 大塚裕忠, 瀧戸次郎, 井上知, 柳澤伸彰, 野中直子, 中村雅典

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 121st 133, 2016
顔面部皮膚領域における抗原提示細胞の局在

柳澤伸彰, 大塚裕忠, 瀧戸次郎, 野中直子, 中島功, 中村雅典

日本顔学会誌, 14(1) 170, Oct 18, 2014

Books and Other Publications

獣医組織学

日本獣医解剖学会

学窓社, Mar, 2020 (ISBN: 9784873627731)

Presentations

加齢性唾液腺内リンパ球浸潤におけるヒスタミンの機能について

大塚裕忠, 三矢雅喜, 大津浩, 野中直子, 添田聡

第１２７回日本解剖学会全国学術集会・総会, Mar 27, 2022
The Function of Histamine in Hepatic Hematopoiesis in Postnatal Mice.

Hirotada Otsuka, Harumi Kasuya, Endo Yasuo, Hiroshi Ohtsu, Masanori Nakamura, Satoshi Soeta

the 126th Annual Meeting of The Japanese Association of Anatomists, the 98th Annual Meeting of The Physiological Society of Japan, joint meeting, Mar 28, 2021
Histidine decarboxylase欠損マウスにおける出生後造血巣の変化に関する研究

大塚裕忠, 粕谷晴美, 遠藤康男, 大津浩, 中村雅典, 添田聡

第１２５回日本解剖学会全国学術集会・総会, Mar 26, 2020
ヒスタミン欠損マウスにおける造血・リンパ性器官の形態学的研究

大塚裕忠

第１２４回日本解剖学会全国学術集会・総会, Mar 29, 2019
BIG-IGF-2 PRODUCING-ADENOCARCINOMA IN A DOG SHOWING HYPOGLYCEMIA.

Shunnya Noguci, Y. Kubo, Daigo Azakami, Hirotada Otsuka, Miki Koh, K. Tamura, M. Michishita, A. Yasuda, Satoshi Soeta

ISACP 18th, Aug, 2018
The establishment of a severely anemic mouse model induced by Nitrogen-containing bisphosphonate and the study of hematopoietic systems in the model

Hirotada Otsuka

Jun 30, 2018 Invited
２つの異なる扁平骨における骨修復過程の解析

井上知, 藤川芳織, 大塚裕忠, 中村雅典

第１２３回日本解剖学会全国学術集会・総会, Mar 30, 2018
髄外造血におけるHistidine decarboxylaseの役割に関する研究

大塚裕忠, 添田聡, 大津浩, 尼崎肇, 中村雅典

第１２３回日本解剖学会全国学術集会・総会, Mar 29, 2018
マウス創傷治癒過程における局所的マクロファージ除去の影響

藤川芳織, 井上知, 瀧戸次郎, 大塚裕忠, 中村雅典

第１２３回日本解剖学会全国学術集会・総会, Mar 29, 2018

Teaching Experience

Nov, 2017 - Present

獣医組織発生学実習
Nov, 2017 - Present

獣医解剖学実習
Nov, 2017 - Present

獣医発生学
Nov, 2017 - Present

獣医組織学
Nov, 2017 - Present

獣医解剖学ⅠーⅢ
Nov, 2017 - Mar, 2020

動物生体機構学

Professional Memberships

Research Projects

ヒスタミンをターゲットとした加齢性唾液腺内リンパ球浸潤の病態解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

大塚裕忠
重症貧血マウスモデルにおける新規造血構造体誘導機構の解明

科学研究費助成事業：若手研究（B）, 文部科学省, Apr, 2017 - Mar, 2019

大塚裕忠
The morphological and functional study of the newly discovered hematopoietic structure induced in a severely anemic mouse model.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Otsuka Hirotada
成体マウスにおける胚子ヘモグロビン再発現機構の解析

科学研究費助成事業：研究活動スタート支援, 文部科学省, Aug, 2012 - Mar, 2014

大塚裕忠

Profile Information

Research Areas

Research History

Awards

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

Research Projects

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Coauthors