論文

査読有り
2013年9月

Telomelysin shows potent antitumor activity through apoptotic and non-apoptotic cell death in soft tissue sarcoma cells

Cancer Science
  • Gui-Dong Li
  • ,
  • Hiroyuki Kawashima
  • ,
  • Akira Ogose
  • ,
  • Takashi Ariizumi
  • ,
  • Tetsuo Hotta
  • ,
  • Ryozo Kuwano
  • ,
  • Yasuo Urata
  • ,
  • Toshiyoshi Fujiwara
  • ,
  • Naoto Endo

104
9
開始ページ
1178
終了ページ
1188
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/cas.12208

This study investigated the pathway underlying the antitumor activity of telomelysin, a telomerase-dependent, replication-selective oncolytic adenovirus, in soft tissue sarcoma cells. Treatment with telomelysin alone resulted in simultaneous induction of apoptosis and autophagy, whereas cotreatment with telomelysin and 3-methyladenine significantly reduced cell viability and increased apoptosis and the cellular ATP level compared to treatment with telomelysin alone, indicating that telomelysin-mediated autophagy is a death-protective but not death-promoting process. Cotreatment with Z-Val-Ala-Asp-CH2F significantly increased cellular ATP depletion compared to telomelysin-alone treatment while inhibiting telomelysin-induced apoptosis and having no significant effect on cell viability, indicating that it promotes transition from apoptotic to necrotic cell death. © 2013 Japanese Cancer Association.

リンク情報
DOI
https://doi.org/10.1111/cas.12208
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23718223
ID情報
  • DOI : 10.1111/cas.12208
  • ISSN : 1347-9032
  • ISSN : 1349-7006
  • PubMed ID : 23718223
  • SCOPUS ID : 84883461573

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