論文

査読有り 国際誌
2018年6月

Long-term renal tubular damage in intrauterine growth-restricted rats.

Pediatrics international : official journal of the Japan Pediatric Society
  • Yayoi Murano
  • ,
  • Hiromichi Shoji
  • ,
  • Taichi Hara
  • ,
  • Naho Ikeda
  • ,
  • Amane Endo
  • ,
  • Naoto Nishizaki
  • ,
  • Toshiaki Shimizu

60
6
開始ページ
565
終了ページ
568
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/ped.13570

BACKGROUND: Intrauterine growth restriction (IUGR) has been shown to be associated with increased risk of renal disease or hypertension in later life. Glomerular dysfunction, however, has mainly been reported, and limited information is available to link IUGR with renal tubular damage. The aim of this study was therefore to investigate urinary markers of tubular damage in a rat model of IUGR induced by bilateral uterine artery ligation. METHODS: Pregnant Sprague-Dawley rats underwent bilateral uterine artery ligation, while the control group underwent sham surgery. RESULTS: Birthweight was reduced, and urinary β2-microglobulin (β2-MG)-, cystatin C (Cys-C)-, and calbindin-to-creatinine ratios were significantly higher at weeks 4 and 8 in the IUGR group compared with the control group. These urinary markers were not significantly different at week 16 between the two groups. Increased excretion of urinary β2-MG, Cys-C, and calbindin was observed in IUGR rats at ≥8 weeks of age. CONCLUSION: Children born with IUGR are at increased risk for renal tubular damage.


リンク情報
DOI
https://doi.org/10.1111/ped.13570
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29575245
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000435805800011&DestApp=WOS_CPL

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