論文

査読有り 国際誌
2018年1月

Urinary prostaglandin D2 metabolite excretion during the first six months of life was significantly lower in breast-fed than formula-fed infants.

Acta paediatrica (Oslo, Norway : 1992)
  • Hiromichi Shoji
  • ,
  • Naho Ikeda
  • ,
  • Tomohiro Kitamura
  • ,
  • Hiroki Suganuma
  • ,
  • Mai Ohba
  • ,
  • Toshiaki Okuno
  • ,
  • Takehiko Yokomizo
  • ,
  • Toshiaki Shimizu

107
1
開始ページ
95
終了ページ
100
記述言語
英語
掲載種別
DOI
10.1111/apa.14068

AIM: The metabolic changes that occur during the postnatal weaning period appear to be particularly important for future health, and breast milk is considered to provide the optimal source of infant nutrition. This pilot study from September 2013 to May 2015 examined the effect of breastfeeding on prostaglandin metabolism in healthy term infants. METHODS: Urine samples were collected from 19 infants at one month of age in the Juntendo University Hospital, Tokyo, Japan. The 13 infants in the breast-fed group received less than 540 mL/week of their intake from formula, and the other six were exclusively fed on formula. At six months, we sampled 14 infants: nine breast-fed and five receiving formula. The infants were from normal single pregnancies and free from perinatal complications. We analysed urinary prostaglandin metabolites-tetranor prostaglandin E2 metabolite (t-PGEM) and tetranor prostaglandin D2 metabolite (t-PGDM)-using liquid chromatography tandem-mass spectrometry. RESULTS: Urinary t-PGDM excretion at one and six months was significantly lower in breast-fed infants than formula-fed infants. However, urinary t-PGEM excretion at one and six months was not significantly different between the groups. CONCLUSION: Our study showed that the type of feeding in early infancy affected prostaglandin metabolism in healthy term infants.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1111/apa.14068
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28898456
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000417865400017&DestApp=WOS_CPL

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