2018年2月20日
Relationship of annual change in bone mineral density with extent of emphysematous lesions and pulmonary function in patients with COPD
International Journal of Chronic Obstructive Pulmonary Disease
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- 巻
- Vol.13
- 号
- 開始ページ
- 639
- 終了ページ
- 644
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2147/COPD.S153750
Osteoporosis is a well-known comorbidity in COPD. It is associated with poor health status and prognosis. Although the exact pathomechanisms are unclear, osteoporosis is suggested to be either a comorbidity due to shared risk factors with COPD or a systematic effect of COPD with a cause-effect relationship. This study aimed to evaluate whether progression of osteoporosis is synchronized with that of COPD. Data from 103 patients with COPD included in the Hokkaido COPD cohort study were analyzed. Computed tomography (CT) attenuation values of thoracic vertebrae 4, 7, and 10 were measured using custom software, and the average value (average bone density; ABD) was calculated. The percentage of low attenuation volume (LAV%) for each patient was also calculated for evaluation of emphysematous lesions. Annual change in thoracic vertebral CT attenuation, which is strongly correlated with dual-energy X-ray absorptiometry-measured bone mineral density, was compared with that in FEV or emphysematous lesions. In the first CT data set, ABD was significantly correlated with age (=-0.331; =0.0006), body mass index (BMI; =0.246; =0.0136), St George's Respiratory Questionnaire (SGRQ) activity score (=-0.248; =0.0115), eosinophil count (=0.229; =0.0198), and LAV% (=-0.372; =0.0001). However, ABD was not associated with FEV. After adjustment for age, BMI, SGRQ activity score, and eosinophil count, no significant relationship was found between ABD and LAV%. Annual change in ABD was not associated with annual change in LAV% or FEV. Progression of osteoporosis and that of COPD are not directly related or synchronized with each other.
- ID情報
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- DOI : 10.2147/COPD.S153750
- ISSN : 1178-2005
- PubMed ID : 29503537