Oct, 2019
High-throughput screening of bioactive compounds via new catalytic reaction in the pooled mixture
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- ,
- Volume
- 29
- Number
- 19
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1016/j.bmcl.2019.06.061
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
To increase the chances of finding new candidate molecules with medicinal properties, while expending less resource and effort, the present study used pooled substrates as starting materials. A bisindole compound that showed inhibitory activity was then isolated from the mixture, and the activity was improved by optimizing the substituents on the indole skeleton.
- Link information
-
- DOI
- https://doi.org/10.1016/j.bmcl.2019.06.061
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000485100200001&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85070556628&partnerID=MN8TOARS
- ID information
-
- DOI : 10.1016/j.bmcl.2019.06.061
- ISSN : 0960-894X
- eISSN : 1464-3405
- ORCID - Put Code : 86494115
- SCOPUS ID : 85070556628
- Web of Science ID : WOS:000485100200001