2021年1月27日
Reaction between Graphene Oxide and Intracellular Glutathione Affects Cell Viability and Proliferation
ACS Applied Materials and Interfaces
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- ,
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- 巻
- 13
- 号
- 3
- 開始ページ
- 3528
- 終了ページ
- 3535
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acsami.0c17523
- 出版者・発行元
- AMER CHEMICAL SOC
Graphene oxide (GO) is currently developed for biomedical applications as a promising nanoplatform for drug delivery, phototherapy, and biosensing. As a consequence, its safety and cytotoxicity issues have attracted extensive attention. It has been demonstrated that GO causes an increase of intracellular oxidative stress, likely leading to its cytotoxicity and inhibition of cell proliferation. Being one of the main reductive intracellular substances, glutathione (GSH) is vital in the regulation of the oxidative stress level to maintain normal cellular functions. In this study, we found that GSH could be oxidized to GSSG by GO, leading to the formation of reduced GO (rGO). GSH depletion affects the intracellular reductive/oxidative balance, provoking the increase of the reactive oxygen species level, sequentially inhibiting cell viability and proliferation. Therefore, the reaction between GO and GSH provides a new perspective to explain the origin of GO cytotoxicity.
- リンク情報
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- DOI
- https://doi.org/10.1021/acsami.0c17523
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/33428377
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000614062400004&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85099993554&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85099993554&origin=inward
- ID情報
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- DOI : 10.1021/acsami.0c17523
- ISSN : 1944-8244
- eISSN : 1944-8252
- PubMed ID : 33428377
- SCOPUS ID : 85099993554
- Web of Science ID : WOS:000614062400004