論文

査読有り 国際誌
2021年12月

Relationship of continuous glucose monitoring-related metrics with HbA1c and residual β-cell function in Japanese patients with type 1 diabetes

Scientific Reports
  • Naru Babaya
  • ,
  • Shinsuke Noso
  • ,
  • Yoshihisa Hiromine
  • ,
  • Yasunori Taketomo
  • ,
  • Fumimaru Niwano
  • ,
  • Sawa Yoshida
  • ,
  • Sara Yasutake
  • ,
  • Yumiko Kawabata
  • ,
  • Hiroshi Ikegami

11
1
開始ページ
1
終了ページ
9
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-021-83599-x
出版者・発行元
Springer Science and Business Media LLC

<title>Abstract</title>The targets for continuous glucose monitoring (CGM)-derived metrics were recently set; however, studies on CGM data over a long period with stable glycemic control are limited. We analyzed 194,279 CGM values obtained from 19 adult Japanese patients with type 1 diabetes. CGM data obtained during stable glycemic control over four months were analyzed. CGM-related metrics of different durations “within 120, 90, 60, 30, and 7 days” were calculated from baseline. Time in range (TIR; glucose 70–180 mg/dL), time above range (TAR; glucose ≥ 181 mg/dL), and average glucose levels, but not time below range (TBR; glucose ≤ 69 mg/dL), strongly correlated with glycated hemoglobin (HbA1c) values (P &lt; 0.0001). TBR correlated with glucose coefficient of variation (CV) (P &lt; 0.01). Fasting serum C-peptide levels negatively correlated with glucose CV (P &lt; 0.01). HbA1c of approximately 7% corresponded to TIR of 74% and TAR of 20%. The shorter the CGM period, the weaker was the relationship between HbA1c and CGM-related metrics. TIR, TAR, and average glucose levels accurately reflected HbA1c values in Japanese patients with type 1 diabetes with stable glycemic control. Glucose CV and TBR complemented the limitation of HbA1c to detect glucose variability and hypoglycemia. Stable glycemic control with minimal hypoglycemia depended on residual β-cell function.

リンク情報
DOI
https://doi.org/10.1038/s41598-021-83599-x
URL
http://www.nature.com/articles/s41598-021-83599-x.pdf
URL
http://www.nature.com/articles/s41598-021-83599-x
ID情報
  • DOI : 10.1038/s41598-021-83599-x
  • eISSN : 2045-2322

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