論文

査読有り
2016年11月

Aromatase inhibitors with or without luteinizing hormone-releasing hormone agonist for metastatic male breast cancer: report of four cases and review of the literature

BREAST CANCER
  • Sayaka Kuba
  • ,
  • Mayumi Ishida
  • ,
  • Masahiro Oikawa
  • ,
  • Yoshiaki Nakamura
  • ,
  • Kosho Yamanouchi
  • ,
  • Eriko Tokunaga
  • ,
  • Kenichi Taguchi
  • ,
  • Taito Esaki
  • ,
  • Susumu Eguchi
  • ,
  • Shinji Ohno

23
6
開始ページ
945
終了ページ
949
記述言語
英語
掲載種別
DOI
10.1007/s12282-016-0679-2
出版者・発行元
SPRINGER JAPAN KK

The roles of aromatase inhibitors (AIs) and luteinizing hormone-releasing hormone (LH-RH) agonists in the management of male breast cancer remain uncertain, with no reports in Japanese men. We report four Japanese male patients with metastatic breast cancer treated with AIs with or without an LH-RH agonist, and consider the relationship between treatment effect and estradiol (E2) concentration. Three patients were initially treated with AI alone after selective estrogen receptor modulators (SERMs), and one received AIs plus an LH-RH agonist after a SERM. Two patients treated with an AI alone responded, one patient with E2 levels below the lower assay limit and the other with levels above the limit. The other treated with an AI alone experienced progression regardless of the E2 levels below the lower assay limit, however, responded after the addition of an LH-RH agonist. E2 concentrations were related to the efficacy of treatment in one patient. The patient initially treated with an AI plus an LH-RH agonist also responded. No grade 3 or 4 adverse events were observed in any of the patients treated with AIs with or without an LH-RH agonist. AIs with or without an LH-RH agonist offer an effective treatment option for hormone receptor-positive metastatic male breast cancer.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1007/s12282-016-0679-2
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26879549
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000387218400018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s12282-016-0679-2
  • ISSN : 1340-6868
  • eISSN : 1880-4233
  • PubMed ID : 26879549
  • Web of Science ID : WOS:000387218400018

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