2018年6月28日
Direct enolization chemistry of 7-azaindoline amides: A case study of bis(tetrahydrophosphole)-type ligands
Tetrahedron
- ,
- ,
- ,
- 巻
- 74
- 号
- 26
- 開始ページ
- 3301
- 終了ページ
- 3305
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.tet.2018.03.073
- 出版者・発行元
- Elsevier Ltd
7-Azaindoline amides are particularly useful in direct enolization chemistry due to their facilitated enolization in soft Lewis acid/Brønsted base cooperative catalysis. The Cu(I) complex of (R,R)-Ph-BPE, a bis(tetrahydrophosphole)-type chiral bisphosphine ligand, exhibits consistently high catalytic performance and stereoselectivity irrespective of the nature of the α-substituent of the amides. Unexpectedly, however, alkyl-substituted bis(tetrahydrophosphole)-type ligands have substantially inferior catalytic performance. Evaluation of the optimized structures of Cu(I)/amide and Cu(I)/enolate complexes provided clues to dissecting the diverted reaction outcomes.
- ID情報
-
- DOI : 10.1016/j.tet.2018.03.073
- ISSN : 1464-5416
- ISSN : 0040-4020
- SCOPUS ID : 85045476735