桑原直之 (Naoyuki Kuwabara) - マイポータル

基本情報

所属: 府省共通研究開発管理システムその他 ‐

J-GLOBAL ID: 201601016237081045
researchmap会員ID: B000255467

外部リンク: https://kaken.nii.ac.jp/d/r/70506253.ja.html

研究キーワード

研究分野

ライフサイエンス / 構造生物化学 /

経歴

2014年

大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 研究員

論文

Novel helical assembly in arginine methyltransferase 8

Sachiko Toma-Fukai, Jun -Dal Kim, Kyung-Eui Parka, Naoyuki Kuwabara, Nobutaka Shimizu, Elena Krayukhina, Susumu Uchiyama, Akiyoshi Fukamizu, Toshiyuki Shimizu

JOURNAL OF MOLECULAR BIOLOGY 428(6) 1197-1208 2016年3月査読有り
A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition

Hirofumi Tanaka, Toshiki Takahashi, Yiming Xie, Ryosuke Minami, Yuko Yanagi, Mizuki Hayashishita, Rigel Suzuki, Naoto Yokota, Masumi Shimada, Tsunehiro Mizushima …

FEBS JOURNAL 283(4) 662-677 2016年2月査読有り
Structure of a BAG6 (Bcl-2-associated Athanogene 6)-Ubl4a (Ubiquitin-like Protein 4a) Complex Reveals a Novel Binding Interface That Functions in Tail-anchored Protein Biogenesis

Naoyuki Kuwabara, Ryosuke Minami, Naoto Yokota, Hirofumi Matsumoto, Toshiya Senda, Hiroyuki Kawahara, Ryuichi Kato

JOURNAL OF BIOLOGICAL CHEMISTRY 290(15) 9387-9398 2015年4月査読有り
Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament

Louise H. Fornander, Axelle Renodon-Corniere, Naoyuki Kuwabara, Kentaro Ito, Yasuhiro Tsutsui, Toshiyuki Shimizu, Hiroshi Iwasaki, Bengt Norden, Masayuki Takahashi

NUCLEIC ACIDS RESEARCH 42(4) 2358-2365 2014年2月査読有り
Conformational change of a unique sequence in a fungal galectin from Agrocybe cylindracea controls glycan ligand-binding specificity

Naoyuki Kuwabara, Dan Hu, Hiroaki Tateno, Hisayoshi Makyio, Jun Hirabayashi, Ryuichi Kato

FEBS Letters 587(22) 3620-3625 2013年11月15日査読有り
Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands

Lisa Asano, Ichiaki Ito, Naoyuki Kuwabara, Tsuyoshi Waku, Junn Yanagisawa, Hiroyuki Miyachi, Toshiyuki Shimizu

FEBS LETTERS 587(7) 957-963 2013年4月査読有り
Characterisation of an intrinsically disordered protein complex of Swi5-Sfr1 by ion mobility mass spectrometry and small-angle X-ray scattering

Kazumi Saikusa, Naoyuki Kuwabara, Yuichi Kokabu, Yu Inoue, Mamoru Sato, Hiroshi Iwasaki, Toshiyuki Shimizu, Mitsunori Ikeguchi, Satoko Akashi

ANALYST 138(5) 1441-1449 2013年査読有り
Mechanistic Insights into the Activation of Rad51-Mediated Strand Exchange from the Structure of a Recombination Activator, the Swi5-Sfr1 Complex

Naoyuki Kuwabara, Yasuto Murayama, Hiroshi Hashimoto, Yuuichi Kokabu, Mitsunori Ikeguchi, Mamoru Sato, Kouta Mayanagi, Yasuhiro Tsutsui, Hiroshi Iwasaki, Toshiyuki Shimizu

STRUCTURE 20(3) 440-449 2012年3月査読有り
Peroxisome Proliferator-Activated Receptors (PPARs) Have Multiple Binding Points That Accommodate Ligands in Various Conformations: Phenylpropanoic Acid-Type PPAR Ligands Bind to PPAR in Different Conformations, Depending on the Subtype

Naoyuki Kuwabara, Takuji Oyama, Daisuke Tomioka, Masao Ohashi, Junn Yanagisawa, Toshiyuki Shimizu, Hiroyuki Miyachi

JOURNAL OF MEDICINAL CHEMISTRY 55(2) 893-902 2012年1月査読有り
Fission Yeast Swi5-Sfr1 Protein Complex, an Activator of Rad51 Recombinase, Forms an Extremely Elongated Dogleg-shaped Structure

Yuichi Kokabu, Yasuto Murayama, Naoyuki Kuwabara, Tomotaka Oroguchi, Hiroshi Hashimoto, Yasuhiro Tsutsui, Naohito Nozaki, Satoko Akashi, Satoru Unzai, Toshiyuki Shimizu …

JOURNAL OF BIOLOGICAL CHEMISTRY 286(50) 43569-43576 2011年12月査読有り
Expression, purification and crystallization of Swi5 and the Swi5-Sfr1 complex from fission yeast

Naoyuki Kuwabara, Hiroshi Hashimoto, Noriyo Yamada, Satoru Unzai, Mitsunori Ikeguchi, Mamoru Sato, Yasuto Murayama, Hiroshi Iwasaki, Toshiyuki Shimizu

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 66(Pt 9) 1124-1126 2010年9月査読有り
Structure of the N-terminal Regulatory Domain of a Plant NADPH Oxidase and Its Functional Implications

Takashi Oda, Hiroshi Hashimoto, Naoyuki Kuwabara, Satoko Akashi, Kokoro Hayashi, Chojiro Kojima, Hann Ling Wong, Tsutomu Kawasaki, Ko Shimamoto, Mamoru Sato …

JOURNAL OF BIOLOGICAL CHEMISTRY 285(2) 1435-1445 2010年1月査読有り
Crystallographic characterization of the N-terminal domain of a plant NADPH oxidase

Takashi Oda, Hiroshi Hashimoto, Naoyuki Kuwabara, Kokoro Hayashi, Chojiro Kojima, Tsutomu Kawasaki, Ko Shimamoto, Mamoru Sato, Toshiyuki Shimizu

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 64(Pt 9) 867-869 2008年9月査読有り
Structure-function relationship of the fifth transmembrane domain in the Na+/H+ antiporter of Helicobacter pylori: Topology and function of the residues, including two consecutive essential aspartate residues

Naoyuki Kuwabara, Hiroki Inoue, Yumi Tsuboi, Keiji Mitsui, Masafumi Matsushita, Hiroshi Kanazawa

BIOCHEMISTRY 45(49) 14834-14842 2006年12月査読有り
The fourth transmembrane domain of the Helicobacter pylori Na(+)/H(+) antiporter NhaA faces a water-filled channel required for ion transport

N Kuwabara, H Inoue, Y Tsuboi, N Nakamura, H Kanazawa

JOURNAL OF BIOLOGICAL CHEMISTRY 279(39) 40567-40575 2004年9月査読有り

共同研究・競争的資金等の研究課題

筋ジストロフィー疾患を引き起こす糖転移酵素の構造機能相関

文部科学省科学研究費補助金(若手研究(B)) 若手研究(B) 2014年 - 2015年

桑原直之
相同組換えに関わる分裂酵母Rad51‐Swi5‐Sfr1複合体の構造生物学的研究

文部科学省科学研究費補助金(若手研究(B)) 若手研究(B) 2011年 - 2012年

桑原直之, 佐藤衛, 池口満徳, 岩崎博史, 清水敏之