2020年1月
Metachromins X and Y from a marine sponge Spongia sp. and their effects on cell cycle progression
Bioorganic & Medicinal Chemistry
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- 巻
- 28
- 号
- 2
- 開始ページ
- 115233
- 終了ページ
- 115233
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.bmc.2019.115233
- 出版者・発行元
- Elsevier BV
New sesquiterpene quinones, metachromins X (1) and Y (2), together with the known metachromins C (3), J (4), and T (5), were isolated as inhibitors of cell cycle progression in the HeLa/Fucci2 cells. The structure of 1 was assigned by spectroscopic data and confirmed by a total synthesis. The planar structure of 2 was determined by interpretation of spectroscopic data, whereas its absolute configuration was analyzed by a combination of chiral HPLC and CD spectroscopy. Metachromins X (1) and C (3) arrested the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bmc.2019.115233
- ISSN : 0968-0896
- PubMed ID : 31848114