赤木謙一 (Ken'ichi AKAGI) - マイポータル

基本情報

所属: 特定国立研究開発法人理化学研究所

学位: 博士（理学）(大阪大学)

J-GLOBAL ID: 201801016710348148
researchmap会員ID: B000308041

研究キーワード

研究分野

経歴

2006年4月 - 現在

医薬基盤研究所

論文

ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures

Naotaka Sekiyama, Kiyofumi Takaba, Saori Maki-Yonekura, Ken-ichi Akagi, Yasuko Ohtani, Kayo Imamura, Tsuyoshi Terakawa, Keitaro Yamashita, Daigo Inaoka, Koji Yonekura …

Proceedings of the National Academy of Sciences 119(38) 2022年9月20日
¹⁹F chemical library and ¹⁹F-NMR for a weakly bound complex structure

Shoko Shinya, Ritsuko Katahira, Kyoko Furuita, Toshihiko Sugiki, Young-Ho Lee, Yoshikazu Hattori, Kohei Takeshita, Atsushi Nakagawa, Aoi Kokago, Ken-ichi Akagi …

RSC Medicinal Chemistry 2022年
Design and synthesis of beta-strand-fixed peptides inhibiting aggregation of amyloid beta-protein

Fumiya Tanaka, Kana Shibata, Yoko Monobe, Ken-ichi Akagi, Yuichi Masuda

BIOORGANIC & MEDICINAL CHEMISTRY 28(18) 2020年9月
Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid β42 at position 35 in Alzheimer's etiology

Kazuma Murakami, Haruka Kato, Mizuho Hanaki, Yoko Monobe, Ken-ichi Akagi, Taiji Kawase, Kenji Hirose, Kazuhiro Irie

RSC Advances 10(33) 19506-19512 2020年
Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88.

Uno M, Watanabe-Nakayama T, Konno H, Akagi KI, Tsutsumi N, Fukao T, Shirakawa M, Ohnishi H, Tochio H

Chemical communications (Cambridge, England) 54(87) 12318-12321 2018年10月査読有り
Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine.

Hanaki M, Murakami K, Katayama S, Akagi KI, Irie K

Bioorganic & medicinal chemistry 26(8) 1538-1546 2018年5月1日査読有り
Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers.

Murakami K, Yoshioka T, Horii S, Hanaki M, Midorikawa S, Taniwaki S, Gunji H, Akagi KI, Kawase T, Hirose K …

Chemical communications (Cambridge, England) 54(49) 6272-6275 2018年査読有り
Sensitivity enhancement by chromatographic peak concentration with ultra-high performance liquid chromatography-nuclear magnetic resonance spectroscopy for minor impurity analysis

Takashi Tokunaga, Ken-ichi Akagi, Masahiko Okamoto

JOURNAL OF CHROMATOGRAPHY A 1508 163-168 2017年7月査読有り
Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity.

Irie Y, Murakami K, Hanaki M, Hanaki Y, Suzuki T, Monobe Y, Takai T, Akagi KI, Kawase T, Hirose K …

ACS chemical neuroscience 8(4) 807-816 2017年4月査読有り
Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis.

Murakami K, Tokuda M, Suzuki T, Irie Y, Hanaki M, Izuo N, Monobe Y, Akagi K, Ishii R, Tatebe H …

Scientific reports 6 29038-29038 2016年7月4日査読有り
Tensin2-deficient mice on FVB/N background develop severe glomerular disease

Kozue Uchio-Yamada, Yoko Monobe, Ken-ichi Akagi, Yoshie Yamamoto, Atsuo Ogura, Noboru Manabe

JOURNAL OF VETERINARY MEDICAL SCIENCE 78(5) 811-818 2016年5月査読有り
UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion

Katsuya Hirasaka, Edward M. Mills, Marie Haruna, Aki Bando, Chika Ikeda, Tomoki Abe, Shohei Kohno, Sara M. Nowinski, Cory U. Lago, Ken-ichi Akagi …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 472(1) 108-113 2016年3月査読有り
Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids.

Hanaki M, Murakami K, Akagi K, Irie K

Bioorganic & medicinal chemistry 24(2) 304-313 2016年1月査読有り
Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region.

Murakami K, Suzuki T, Hanaki M, Monobe Y, Akagi K, Irie K

Biochemical and biophysical research communications 466(3) 463-467 2015年10月査読有り
Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation

Masao Takeuchi, Atsunori Higashino, Kikuko Takeuchi, Yutaro Hori, Kazuko Koshiba-Takeuchi, Hatsune Makino, Yoko Monobe, Marina Kishida, Jun Adachi, Jun Takeuchi …

PLOS ONE 10(5) e0126562 2015年5月査読有り
Correction: Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation.

Takeuchi M, Higashino A, Takeuchi K, Hori Y, Koshiba-Takeuchi K, Makino H, Monobe Y, Kishida M, Adachi J, Takeuchi J …

PloS one 10(6) e0131383 2015年査読有り
Involvement of Gln679, in addition to Trp687, in chitin-binding activity of the chitin-binding domain of chitinase A1 from Bacillus circulans WL-12

Masashi Hara, Hayuki Sugimoto, Michio Uemura, Ken-ichi Akagi, Kazushi Suzuki, Takahisa Ikegami, Takeshi Watanabe

JOURNAL OF BIOCHEMISTRY 154(2) 185-193 2013年8月査読有り
Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.

Sato M, Murakami K, Uno M, Nakagawa Y, Katayama S, Akagi K, Masuda Y, Takegoshi K, Irie K

The Journal of biological chemistry 288(32) 23212-23224 2013年8月査読有り
Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains

Hiroaki Tanaka, Ken-Ichi Akagi, Chitose Oneyama, Masakazu Tanaka, Yuichi Sasaki, Takashi Kanou, Young-Ho Lee, Daisuke Yokogawa, Marc-Werner Dobenecker, Atsushi Nakagawa …

Journal of Biological Chemistry 288(21) 15240-15254 2013年5月24日査読有り
Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation.

Sato M, Murakami K, Uno M, Ikubo H, Nakagawa Y, Katayama S, Akagi K, Irie K

Bioscience, biotechnology, and biochemistry 77(5) 1100-1103 2013年5月査読有り

もっとみる

MISC

進歩総説 LC-NMR

赤木謙一

ぶんせき 2018(3) 102-109 2018年3月
LC-NMR/MSを用いた生薬の品質評価法に関する研究(1) : 生薬ゴシツの栽培および加工調製法について

渕野裕之, 菱田敦之, 赤木謙一, 木内文之, 川原信夫

生薬學雜誌 : shoyakugaku zasshi : the Japanese journal of pharmacognosy 66(1) 1-16 2012年2月20日
1C1630 SMN(Survival Motor Neuron)蛋白質Tudor domainの構造解析

赤木謙一, 児玉高志, 辻本賀英, 京極好正, 阿久津秀雄

生物物理 40 S24 2000年
NMRによるSigma 70-subunit-region 4の構造解析

赤木謙一, 山崎俊夫, 藤田信之, 石浜明, 京極好正

生物物理 37 S166 1997年10月

所属学協会

日本核磁気共鳴学会