論文

査読有り 筆頭著者
2021年2月

Immunomodulation by Inflammation during Liver and Gastrointestinal Tumorigenesis and Aging

International Journal of Molecular Sciences
  • Nagai N
  • ,
  • Kudo Y
  • ,
  • Aki D
  • ,
  • Nakagawa H
  • ,
  • Taniguchi K

22
5
開始ページ
2238
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/ijms22052238
出版者・発行元
MDPI AG

Chronic inflammation is thought to promote tumorigenesis and metastasis by several mechanisms, such as affecting tumor cells directly, establishing a tumor-supporting microenvironment, enhancing tumor angiogenesis, and suppressing antitumor immunity. In this review, we discuss the recent advances in our understanding of how inflammation induces the immunosuppressive tumor microenvironment, such as increasing the level of pro-inflammatory cytokines, chemokines, and immunosuppressive molecules, inducing immune checkpoint molecules and cytotoxic T-cell exhaustion, and accumulating regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSCs). The suppression of antitumor immunity by inflammation is especially examined in the liver and colorectal cancer. In addition, chronic inflammation is induced during aging and causes age-related diseases, including cancer, by affecting immunity. Therefore, we also discuss the age-related diseases regulated by inflammation, especially in the liver and colon.

リンク情報
DOI
https://doi.org/10.3390/ijms22052238
URL
https://www.mdpi.com/1422-0067/22/5/2238/pdf

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