1997年5月
NGF and BDNF increase the immunoreactivity of vesicular acetylcholine transporter in cultured neurons from the embryonic rat septum
NEUROSCIENCE LETTERS
- ,
- ,
- ,
- 巻
- 226
- 号
- 3
- 開始ページ
- 207
- 終了ページ
- 209
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0304-3940(97)00284-X
- 出版者・発行元
- ELSEVIER SCI IRELAND LTD
The expression of vesicular acetylcholine transporter (VAChT), which transports ACh into synaptic vesicles, is coregulated with choline acetyltransferase (ChAT). Therefore, the effects of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) on the levels of VAChT in cultured neurons from the septum of embryonic rats were investigated by immunocytochemistry. NGF and BDNF increased the number of VAChT-immunoreactive neurons by approximately 1.5-fold and enhanced the immunoreactivity in each positive cell. These results suggest that the neurotrophins enhance not only synthesis but also storage of ACh in septal neurons. (C) 1997 Elsevier Science Ireland Ltd.
- リンク情報
- ID情報
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- DOI : 10.1016/S0304-3940(97)00284-X
- ISSN : 0304-3940
- PubMed ID : 9175603
- Web of Science ID : WOS:A1997WY62200017