2014年9月
A possible link between BDNF and mTOR in control of food intake
FRONTIERS IN PSYCHOLOGY
- ,
- ,
- ,
- ,
- 巻
- 5
- 号
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3389/fpsyg.2014.01093
- 出版者・発行元
- FRONTIERS RESEARCH FOUNDATION
Food intake is intricately regulated by glucose, amino acids, hormones, neuropeptides, and trophic factors through a neural circuit in the hypothalamus. Brain-derived neurotrophic factor (BDNF), the most prominent neurotrophic factor in the brain, regulates differentiation, maturation, and synaptic plasticity throughout life. Among its many roles, BDNF exerts an anorexigenic function in the brain. However, the intracellular signaling induced by BDNF to control food intake is not fully understood. One candidate for the molecule involved in transducing the anorexigenic activity of BDNF is the mammalian target of rapamycin (mTOR). mTOR senses extracellular amino acids, glucose, growth factors, and neurotransmitters, and regulates anabolic reactions response to these signals. Activated mTOR increases protein and lipid synthesis and inhibits protein degradation. In the hypothalamus, mTOR activation is thought to reduce food intake. Here we summarize recent findings regarding BDNF- and mTOR-mediated feeding control, and propose a link between these molecules in eating behavior.
- リンク情報
- ID情報
-
- DOI : 10.3389/fpsyg.2014.01093
- ISSN : 1664-1078
- Web of Science ID : WOS:000342124300001