論文

査読有り 国際誌
2009年5月

Do parkinsonian patients have trouble telling lies? The neurobiological basis of deceptive behaviour.

Brain
  • Nobuhito Abe
  • Toshikatsu Fujii
  • Kazumi Hirayama
  • Atsushi Takeda
  • Yoshiyuki Hosokai
  • Toshiyuki Ishioka
  • Yoshiyuki Nishio
  • Kyoko Suzuki
  • Yasuto Itoyama
  • Shoki Takahashi
  • Hiroshi Fukuda
  • Etsuro Mori
  • 全て表示

132
5
開始ページ
1386
終了ページ
95
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/brain/awp052

Parkinson's disease is a common neurodegenerative disorder with both motor symptoms and cognitive deficits such as executive dysfunction. Over the past 100 years, a growing body of literature has suggested that patients with Parkinson's disease have characteristic personality traits such as industriousness, seriousness and inflexibility. They have also been described as 'honest', indicating that they have a tendency not to deceive others. However, these personality traits may actually be associated with dysfunction of specific brain regions affected by the disease. In the present study, we show that patients with Parkinson's disease are indeed 'honest', and that this personality trait might be derived from dysfunction of the prefrontal cortex. Using a novel cognitive task, we confirmed that patients with Parkinson's disease (n = 32) had difficulty making deceptive responses relative to healthy controls (n = 20). Also, using resting-state (18)F-fluorodeoxyglucose PET, we showed that this difficulty was significantly correlated with prefrontal hypometabolism. Our results are the first to demonstrate that the ostensible honesty found in patients with Parkinson's disease has a neurobiological basis, and they provide direct neuropsychological evidence of the brain mechanisms crucial for human deceptive behaviour.

リンク情報
DOI
https://doi.org/10.1093/brain/awp052
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19339257
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677797
ID情報
  • DOI : 10.1093/brain/awp052
  • PubMed ID : 19339257
  • PubMed Central 記事ID : PMC2677797

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