2017年12月
Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
- 巻
- 32
- 号
- 12
- 開始ページ
- 1241
- 終了ページ
- 1246
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/gps.4600
- 出版者・発行元
- WILEY
Background/AimsInteraction of receptor for advanced glycation end products (RAGE) with amyloid- increases amplification of oxidative stress and plays pathological roles in Alzheimer's disease (AD). Oxidative stress leads to -synuclein aggregation and is also a major contributing factor in the pathogenesis of Lewy body dementias (LBDs). Therefore, we aimed to investigate whether RAGE gene polymorphisms were associated with AD and LBDs.
MethodsFour single nucleotide polymorphisms (SNPs)rs1800624, rs1800625, rs184003, and rs2070600of the gene were analyzed using a case-control study design comprising 288AD patients, 76 LBDs patients, and 105 age-matched controls.
ResultsLinkage disequilibrium (LD) examination showed strong LD from rs1800624 to rs2070600 on the gene (1.1kb) in our cases in Japan. Rs184003 was associated with an increased risk of AD. Although there were no statistical associations for the other three SNPs, haplotypic analyses detected genetic associations between AD and the RAGE gene. Although relatively few cases were studied, results from the SNPs showed that they did not modify the risk of developing LBDs in the Japanese population.
ConclusionOur findings suggested that polymorphisms in the RAGE gene are involved in genetic susceptibility to AD. Copyright (c) 2016 John Wiley & Sons, Ltd.
MethodsFour single nucleotide polymorphisms (SNPs)rs1800624, rs1800625, rs184003, and rs2070600of the gene were analyzed using a case-control study design comprising 288AD patients, 76 LBDs patients, and 105 age-matched controls.
ResultsLinkage disequilibrium (LD) examination showed strong LD from rs1800624 to rs2070600 on the gene (1.1kb) in our cases in Japan. Rs184003 was associated with an increased risk of AD. Although there were no statistical associations for the other three SNPs, haplotypic analyses detected genetic associations between AD and the RAGE gene. Although relatively few cases were studied, results from the SNPs showed that they did not modify the risk of developing LBDs in the Japanese population.
ConclusionOur findings suggested that polymorphisms in the RAGE gene are involved in genetic susceptibility to AD. Copyright (c) 2016 John Wiley & Sons, Ltd.
- リンク情報
- ID情報
-
- DOI : 10.1002/gps.4600
- ISSN : 0885-6230
- eISSN : 1099-1166
- PubMed ID : 27699858
- Web of Science ID : WOS:000416425200028