下田修義 (Nobuyoshi Shimoda) - マイポータル

基本情報

所属: 独立行政法人国立長寿医療研究センターゲノム機能解析室室長

J-GLOBAL ID: 200901025047008736
researchmap会員ID: 5000094373

研究キーワード

研究分野

論文

The loss‐of‐function variant in MFSD3 could play a crucial role in the pathogenesis of dementia with Lewy bodies

Tetsuaki Kimura, Mutsumi Suganuma, Kayoko Sawamura, Yuya Asanomi, Nobuyoshi Shimoda, Noboru Ogiso, Tohru Hosoyama, Shumpei Niida, Kouichi Ozaki, Daichi Shigemizu

Alzheimer's & Dementia 20(S1) 2024年12月
Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation.

Fumihiko Yasuno, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda …

Brain, behavior, & immunity - health 38 100795-100795 2024年7月
CRISPR/Cas9-mediated knock-in cells of the late-onset Alzheimer's disease-risk variant, SHARPIN G186R, reveal reduced NF-κB pathway and accelerated Aβ secretion.

Yuya Asanomi, Tetsuaki Kimura, Nobuyoshi Shimoda, Daichi Shigemizu, Shumpei Niida, Kouichi Ozaki

Journal of human genetics 2024年2月13日
Neuroimaging biomarkers of glial activation for predicting the annual cognitive function decline in patients with Alzheimer's disease.

Fumihiko Yasuno, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda …

Brain, behavior, and immunity 2023年8月28日
Microarray transcriptome datasets of maternal-zygotic DNA methyltransferase 3aa−/− zebrafish during early developmental stages

Masaki Shirai, Nobuyoshi Shimoda, Haruko Takahashi, Kazuya Takayama, Yutaka Kikuchi

Data in Brief 47 108967-108967 2023年4月査読有り
Estimation of blood-based biomarkers of glial activation related to neuroinflammation

Fumihiko Yasuno, Atsushi Watanabe, Yasuyuki Kimura, Yumeka Yamauchi, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi …

Brain, Behavior, & Immunity - Health 26 100549-100549 2022年12月査読有り
Involvement of inflammation in the medial temporal region in the development of agitation in Alzheimer's disease: an in vivo positron emission tomography study

Fumihiko Yasuno, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda …

Psychogeriatrics 2022年11月20日査読有り
Methylome data derived from maternal-zygotic DNA methyltransferase 3aa zebrafish

Masaki Shirai, Kazuya Takayama, Haruko Takahashi, Yudai Hirose, Masashi Fujii, Akinori Awazu, Nobuyoshi Shimoda, Yutaka Kikuchi

Data in Brief 44 108514-108514 2022年10月査読有り
Identification of aberrant transcription termination at specific gene loci with DNA hypomethylated transcription termination sites caused by DNA methyltransferase deficiency.

Masaki Shirai, Takuya Nara, Haruko Takahashi, Kazuya Takayama, Yuan Chen, Yudai Hirose, Masashi Fujii, Akinori Awazu, Nobuyoshi Shimoda, Yutaka Kikuchi

Genes & genetic systems 2022年6月18日査読有り
Kinetic modeling and non-invasive approach for translocator protein quantification with 11C-DPA-713

Fumihiko Yasuno, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Junichiro Abe, Hiroyuki Minami, Takashi Nihashi, Kastunori Yokoi, Saori Hattori, Nobuyoshi Shimoda …

Nuclear Medicine and Biology 108-109 76-84 2022年5月査読有り
Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer's disease patients.

Risa Mitsumori, Kazuya Sakaguchi, Daichi Shigemizu, Taiki Mori, Shintaro Akiyama, Kouichi Ozaki, Shumpei Niida, Nobuyoshi Shimoda

PloS one 15(9) e0239196 2020年査読有り
Expression patterns of dnmt3aa, dnmt3ab, and dnmt4 during development and fin regeneration in zebrafish.

Kazuya Takayama, Nobuyoshi Shimoda, Shunsuke Takanaga, Shunya Hozumi, Yutaka Kikuchi

Gene expression patterns : GEP 14(2) 105-10 2014年3月査読有り
Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging.

Nobuyoshi Shimoda, Toshiaki Izawa, Akio Yoshizawa, Hayoto Yokoi, Yutaka Kikuchi, Naohiro Hashimoto

Age (Dordrecht, Netherlands) 36(1) 103-15 2014年2月査読有り
No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos.

Nobuyoshi Shimoda, Kentaro Hirose, Reiya Kaneto, Toshiaki Izawa, Hayato Yokoi, Naohiro Hashimoto, Yutaka Kikuchi

PloS one 9(12) e114816 2014年査読有り
Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin.

Kentaro Hirose, Nobuyoshi Shimoda, Yutaka Kikuchi

Epigenetics 8(9) 899-906 2013年9月査読有り
Expression patterns of lgr4 and lgr6 during zebrafish development

Kentaro Hirose, Nobuyoshi Shimoda, Yutaka Kikuchi

GENE EXPRESSION PATTERNS 11(7) 378-383 2011年10月査読有り
Identification of a gene required for de novo DNA methylation of the zebrafish no tail gene.

Nobuyoshi Shimoda, Kimi Yamakoshi, Akimitsu Miyake, Hiroyuki Takeda

Developmental dynamics : an official publication of the American Association of Anatomists 233(4) 1509-16 2005年8月査読有り
Generation of aberrant transcripts of and free DNA ends in zebraf ish no tail gene

K Yamakoshi, Y Shishido, N Shimoda

MARINE BIOTECHNOLOGY 7(3) 163-172 2005年5月査読有り
De novo DNA methylation at the CpG island of the zebrafish no tail gene.

Kimi Yamakoshi, Nobuyoshi Shimoda

Genesis (New York, N.Y. : 2000) 37(4) 195-202 2003年12月査読有り
PCR-based cloning of an intronless zebrafish no tail gene

K Yamakoshi, N Shimoda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 306(2) 598-602 2003年6月査読有り

もっとみる

主要な共同研究・競争的資金等の研究課題

造血におけるゼブラフィッシュDnmt3aa標的ゲノム領域と領域特異化因子の解明

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C) 2018年4月 - 2021年3月

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もっとみる

下田修義

基本情報

研究キーワード

研究分野

論文

主要な共同研究・競争的資金等の研究課題

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