円山信之 (Nobuyuki Enzan) - マイポータル

基本情報

所属: The Broad Institute of MIT and Harvard Cardiovascular Disease Initiative Postdoctoral Associate

学位: 博士 (医学)(2022年3月九州大学)

研究者番号: 80962919
ORCID iD: https://orcid.org/0000-0002-3899-4405
J-GLOBAL ID: 202301013835329294
researchmap会員ID: R000051977

研究キーワード

研究分野

経歴

2024年4月 - 現在

特定国立研究開発法人理化学研究所, 生命医科学研究センター, 客員研究員
2024年4月 - 現在

The Broad Institute of MIT and Harvard, Cardiovascular Disease Initiative, Postdoctoral Associates
2022年4月 - 2024年3月

九州大学, 大学院医学研究院循環器内科学, 共同研究員
2022年4月 - 2024年3月

特定国立研究開発法人理化学研究所, 生命医科学研究センター, リサーチアソシエイト
2017年4月 - 2018年3月

九州大学病院, 循環器内科, 医員
2013年4月 - 2017年3月

麻生飯塚病院, 循環器内科, 医師
2011年4月 - 2013年3月

麻生飯塚病院, 初期研修医

学歴

2018年4月 - 2022年3月

九州大学, 大学院医学系学府, 循環器内科学
2005年4月 - 2011年3月

九州大学, 医学部, 医学科

受賞

2025年4月

AHA Postdoctoral Fellowship
2023年10月

第27回日本心不全学会学術集会 Young Investigator Award 最優秀賞
2023年3月

第87回日本循環器学会学術集会 Young Investigator Award 最優秀賞
2021年10月

第25回日本心不全学会学術集会 Young Investigator Award 優秀賞
2020年10月

Resuscitation Science Symposium 2020, Young Investigator Award
2020年10月

第24回日本心不全学会学術集会 Young Investigator Award 優秀賞
2019年10月

第23回日本心不全学会学術集会 Young Investigator Award 優秀賞

論文

Prognostic Value of In-Hospital Nutritional Status Improvement in Heart Failure: Insights From JROADHF-NEXT Registry

Toshitaka Okabe, Keisuke Kida, Nobuyuki Enzan, Masataka Ikeda, Takahiro Okumura, Takeshi Kitai, Takeshi Tohyama, Tatsunori Taniguchi, Shouji Matsushima, Yuya Matsue …

Global Heart 2026年3月13日
Predicting survival in patients with heart failure aged 80 years and older.

Takuya Nagata, Takeshi Tohyama, Masataka Ikeda, Hiroko Watanabe, Hidetaka Kaku, Nobuyuki Enzan, Shouji Matsushima, Takeo Fujino, Toru Hashimoto, Masao Takemoto …

ESC heart failure 13(1) 2026年2月3日
Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population

Nobuyuki Enzan, Kazuo Miyazawa, Satoshi Koyama, Ryo Kurosawa, Hirotaka Ieki, Hiroki Yoshida, Fumie Takechi, Masashi Fukuyama, Ryosuke Osako, Kohei Tomizuka …

Nature Communications 16(1) 2025年11月3日査読有り筆頭著者
Multi-trait polygenic risk scores improve genomic prediction of atrial fibrillation across diverse ancestries

Sean Jurgens, Poeya Haydarlou, Daria Kramarenko, Marre Corver, Nobuyuki Enzan, Dominic Zimmerman, Patrick Ellinor, Connie Bezzina

2025年10月3日
Association between sodium-glucose Co-transporter-2 inhibitor use and prognosis in underweight patients with diabetes mellitus and heart failure

Yudai Fujimoto, Keisuke Kida, Norio Suzuki, Tomomi Ide, Shouji Matsushima, Hidetaka Kaku, Nobuyuki Enzan, Masataka Ikeda, Takeshi Kitai, Tatsunori Taniguchi …

Clinical Nutrition ESPEN 69 767-774 2025年10月査読有り
Frailty Scale Captures Multidimensional Vulnerability and Predicts Mortality in Heart Failure

Taisuke Nakade, Yudai Fujimoto, Yu Suresvar Singh, Yuka Akama, Tomomi Ide, Keisuke Kida, Shouji Matsushima, Hidetaka Kaku, Nobuyuki Enzan, Masataka Ikeda …

JACC 2025年10月査読有り
Goreisan attenuates cardiac hypertrophy and diastolic dysfunction in heart failure with preserved ejection fraction induced by HFD/L-NAME via regulation of ICAT-β-catenin/ERK axis

Yoko Shojima Isayama, Shouji Matsushima, Keisuke Shinohara, Koichi Isayama, Nobuyuki Enzan, Taishi Yamamoto, Masashi Sada, Ryo Miyake, Yoshitomo Tsutsui, Takayuki Toyohara …

Hypertension Research 48(11) 2882-2896 2025年9月3日査読有り
Clinical characteristics and outcomes of hospitalized patients with heart failure from the Japanese prospective registry

Nobuyuki Enzan, Takeshi Tohyama, Tatsuya Watanabe, Takuya Nagata, Eri Noda, Yoshitomo Tsutsui, Masataka Ikeda, Takafumi Sakamoto, Shouji Matsushima, Yuya Matsue …

Journal of Cardiology 2025年5月査読有り筆頭著者
Prognostic impact of moderate to severe anemia associated with renal dysfunction in patients with heart failure

Eri Noda, Shouji Matsushima, Toru Hashimoto, Yoshitomo Tsutsui, Kayo Misumi, Nobuyuki Enzan, Keimei Yoshida, Keisuke Shinohara, Takeo Fujino, Shunsuke Katsuki …

Scientific Reports 15(1) 2025年1月31日査読有り
Management and outcomes of heart failure hospitalization among older adults in the United States and Japan.

Benjamin A. Bates, Enzan N, Tohyama T, Gandhi P, Matsushima S, Tsutsui H, Soko Setoguchi, Ide T

ESC heart failure 2024年7月8日査読有り筆頭著者
Evaluation of the A2B Score for Prediction of Survival in Patients With Heart Failure in a Nationwide Cohort in Japan.

Atsushi Kyodo, Yasuki Nakada, Maki Nogi, Kazutaka Nogi, Satomi Ishihara, Tomoya Ueda, Takeshi Tohyama, Nobuyuki Enzan, Tomomi Ide, Shouji Matsushima …

Journal of the American Heart Association 13(4) e031104 2024年2月20日査読有り
Atrial fibrillation type and long-term clinical outcomes in hospitalized patients with heart failure: insight from JROADHF.

Yasuhiro Hamatani, Nobuyuki Enzan, Moritake Iguchi, Takashi Yoshizawa, Tetsuma Kawaji, Tomomi Ide, Takeshi Tohyama, Shouji Matsushima, Mitsuru Abe, Hiroyuki Tsutsui …

European heart journal. Quality of care & clinical outcomes 2024年1月17日査読有り
IFN-γ-STAT1-ERK Pathway Mediates Protective Effects of Invariant Natural Killer T Cells Against Doxorubicin-Induced Cardiomyocyte Death.

Masashi Sada, Shouji Matsushima, Masataka Ikeda, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Tomonori Tadokoro, Nobuyuki Enzan, Taishi Yamamoto, Hiroko Deguchi Miyamoto …

JACC. Basic to translational science 8(8) 992-1007 2023年8月査読有り
Efficacy of Early Catheter Ablation for Atrial Fibrillation After Admission for Heart Failure.

Kazuo Sakamoto, Takeshi Tohyama, Tomomi Ide, Yasushi Mukai, Nobuyuki Enzan, Takuya Nagata, Masataka Ikeda, Susumu Takase, Tomomi Nagayama, Takeo Fujino …

JACC. Clinical electrophysiology 9(9) 1948-1959 2023年7月19日査読有り
Prevalence, Characteristics and Cardiovascular and Non-cardiovascular Outcomes in Patients with Heart Failure with Supra-normal Ejection Fraction; Insight from the JROADHF Study.

Yu Horiuchi, Masahiko Asami, Tomomi Ide, Kazuyuki Yahagi, Kota Komiyama, Hitomi Yuzawa, Jun Tanaka, Jiro Aoki, Shouji Matsushima, Takeshi Tohyama …

European journal of heart failure 25(7) 989-998 2023年5月16日査読有り
Regional Variation in the Clinical Practice and Prognosis in Patients With Heart Failure With Reduced Ejection Fraction in Japan - A Report From the Japanese Registry of Acute Decompensated Heart Failure (JROADHF).

Yu Sato, Akiomi Yoshihisa, Tomomi Ide, Takeshi Tohyama, Nobuyuki Enzan, Shouji Matsushima, Hiroyuki Tsutsui, Yasuchika Takeishi

Circulation journal : official journal of the Japanese Circulation Society 87(10) 1380-1391 2023年4月28日査読有り
ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts.

Nobuyuki Enzan, Shouji Matsushima, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Taishi Yamamoto, Masashi Sada, Ryo Miyake, Yoshitomo Tsutsui, Ryohei Nishimura …

Circulation research 132(9) 1110-1126 2023年4月28日査読有り筆頭著者
Propensity-Matched Study of Early Cardiac Rehabilitation in Patients With Acute Decompensated Heart Failure.

Nobuyuki Enzan, Shouji Matsushima, Hidetaka Kaku, Takeshi Tohyama, Tomoyuki Nezu, Tae Higuchi, Yuta Nagatomi, Takeo Fujino, Toru Hashimoto, Tomomi Ide …

Circulation. Heart failure 16(4) e010320 2023年4月査読有り筆頭著者責任著者
Nationwide Temporal Trends in Clinical Characteristics and Treatment of Dilated Cardiomyopathy From 2003 to 2013 in Japan - A Report From Clinical Personal Records.

Yoshitomo Tsutsui, Shouji Matsushima, Nobuyuki Enzan, Eri Noda, Keisuke Shinohara, Toru Hashimoto, Tomomi Ide, Shintaro Kinugawa, Hiroyuki Tsutsui

Circulation journal : official journal of the Japanese Circulation Society 87(4) 500-507 2023年3月24日査読有り
Long-Term Outcomes of Heart Failure Patients With Preserved, Mildly Reduced, and Reduced Ejection Fraction

Takuya Nagata, Tomomi Ide, Takeshi Tohyama, Hidetaka Kaku, Nobuyuki Enzan, Shouji Matsushima, Masataka Ikeda, Koji Todaka, Hiroyuki Tsutsui

JACC: Asia 2023年3月査読有り

もっとみる

MISC

循環器疾患におけるゲノム・オミクス研究の過去・現在・未来の展望

円山信之, 伊藤薫

心臓 54(10) 1086-1093 2022年10月筆頭著者
Plasma B-type Natriuretic Peptide Levels Are Associated With Future Cardiovascular Events in Patients With Type 2 Diabetes Mellitus Without Known Cardiovascular Disease

Shota Ikeda, Keisuke Shinohara, Nobuyuki Enzan, Shouji Matsushima, Takeshi Tohyama, Kouta Funakoshi, Junji Kishimoto, Hiroshi Itoh, Issei Komuro, Hiroyuki Tsutsui

CIRCULATION 142 2020年11月17日

講演・口頭発表等

The use of mineralocorticoid receptor antagonists but not renin-angiotensin system inhibitors is associated with better outcomes in patients with heart failure and advanced chronic kidney disease

Nobuyuki Enzan, Shouji Matsushima, Hidetaka Kaku, Takeshi Tohyama, Takuya Nagata, Tomomi Ide, Hiroyuki Tsutsui

American Heart Association Scientific Sessions 2023 2023年11月12日
In-hospital cardiac rehabilitation is associated with better long-term outcomes in patients with acute decompensated heart failure

Nobuyuki Enzan, Shouji Matsushima, Hidetaka Kaku, Takeshi Tohyama, Tomoyuki Nezu, Tae Higuchi, Yuta Nagatomi, Takeo Fujino, Toru Hashimoto, Tomomi Ide, Hiroyuki Tsutsui

第27回⽇本⼼不全学会学術集会 2023年10月6日
ZBP1 protects against mitochondrial DNA-induced myocardial inflammation in failing hearts by suppressing RIPK3-NF-κB pathway

Nobuyuki Enzan, Shouji Matsushima, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Taishi Yamamoto, Masashi Sada, Ryo Miyake, Yoshitomo Tsutsui, Ryohei Nishimura, Takayuki Toyohara, Yuki Ikeda, Yoko Shojima, Hiroko Deguchi Miyamoto, Tomonori Tadokoro, Masataka Ikeda, Kohtaro Abe, Tomomi Ide, Shintaro Kinugawa, Hiroyuki Tsutsui

第87回日本循環器学会学術集会 2023年3月10日
Beneficial effects of dipeptidyl peptidase-4 inhibitors on heart failure with preserved ejection fraction and diabetes

Nobuyuki Enzan, Shouji Matsushima, Hidetaka Kaku, Takeshi Tohyama, Takuya Nagata, Tomomi Ide, Hiroyuki Tsutsui

第26回日本心不全学会学術集会 2022年10月21日
Inpatient Cardiac Rehabilitation After Hospitalization for Acute Decompensated Heart Failure is Associated With Reduced Cardiovascular Events

Nobuyuki Enzan, Shouji Matsushima, Tomomi Ide, Hidetaka Kaku, Takeshi Tohyama, Kouta Funakoshi, Taiki Higo, Hiroyuki Tsutsui

American Heart Association Scientific Sessions 2021 2021年11月13日
The use of angiotensin receptor blockers is associated with greater recovery of cardiac function than angiotensin-converting-enzyme inhibitors among patients with dilated cardiomyopathy

Nobuyuki Enzan, Shouji Matsushima, Tomomi Ide, Takeshi Tohyama, Kouta Funakoshi, Taiki Higo, Hiroyuki Tsutsui

European-Society-of-Cardiology (ESC) Congress 2021年8月27日
Targeted Temperature Management is Associated with Improved Neurological Outcomes in Witnessed Out-of-hospital Cardiac Arrest Patients Who Achieve Early Return of Spontaneous Circulation

Nobuyuki Enzan, Ken-ichi Hiasa, Kenzo Ichimura, Masaaki Nishihara, Takeshi Iyonaga, Yuji Shono, Takanari Kitazono, Hiroyuki Tsutsui

Scientific Sessions of American-Heart-Association / Resuscitation Science Symposium 2020 2020年11月14日
Delayed Administration of Epinephrine is Associated with Worse Neurological Outcomes in Patients with Out-of-hospital Cardiac Arrest and Initial Pulseless Electrical Activity

Nobuyuki Enzan, Ken-ichi Hiasa, Kenzo Ichimura, Masaaki Nishihara, Takeshi Iyonaga, Yuji Shono, Takanari Kitazono, Hiroyuki Tsutsui

Scientific Sessions of American-Heart-Association / Resuscitation Science Symposium 2020 2020年11月14日
Sex Differences on Time-dependent Changes in Brain-type Natriuretic Peptide Among Patients With Hypertrophic Cardiomyopathy

Nobuyuki Enzan, Shouji Matsushima, Tomomi Ide, Hidetaka Kaku, Takeshi Tohyama, Kouta Funakoshi, Taiki Higo, Hiroyuki Tsutsui

American Heart Association Scientific Sessions 2020 2020年11月14日
Use of direct oral anticoagulants is associated with better long-term outcomes in patients with atrial fibrillation and heart failure as compared with vitamin K antagonists

Nobuyuki Enzan, Shouji Matsushima, Tomomi Ide, Hidetaka Kaku, Takeshi Tohyaina, Kouta Funakoshi, Taiki Higo, Hiroyuki Tsulsui

European-Society-of-Cardiology (ESC) Congress 2020年8月30日
Beta-blocker use is associated with prevention of left ventricular remodeling in recovered dilated cardiomyopathy

Nobuyuki Enzan, Shouji Matsushima, Tomomi Ide, Hidetaka Kaku, Taiki Higo, Hiroyuki Tsutsui

Annual Meeting of the European-Society-of-Cardiology (ESC) 2020年8月30日
Spironolactone use at discharge is associated with improved outcomes in hospitalized patients with heart failure with mid-range ejection fraction

Nobuyuki Enzan, Shouji Matsushima, Tomomi Ide, Hidetaka Kaku, Taiki Higo, Hiroyuki Tsutsui

American Heart Association Scientific Sessions 2019 2019年11月16日
THE REDUCTION OF LEFT VENTRICULAR MASS IS SMALLER IN PATIENTS WITH LOW PRESSURE GRADIENT SEVERE AORTIC STENOSIS AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION

Nobuyuki Enzan, Ken-Ichi Hiasa, Shunji Hayashidani, Keiji Oi, Takeshi Arita, Hiromichi Sonoda, Akira Shiose, Tsutsui Hiroyuki

Annual Meeting of the American College of Cardiology (ACC) 2018年3月12日
Physician presence in the emergency medical services improves neurological outcome of out-of-hospital cardiac arrest patients with non-shockable initial rhythm

Nobuyuki Enzan, Takaki Tsutsumi, Yoshihiro Imamura, Akira Yamada

Annual Meeting of the European-Society-of-Cardiology (ESC) 2017年8月27日
A case of late left ventricular pseudoaneurysm after aortic valve replacement for infective endocarditis

Nobuyuki Enzan, Takaki Tsutsumi, Yoshihiro Imamura, Akira Yamada

EuroEcho-Imaging 2016 2016年12月8日
A case of cardiogenic shock complicated with ST elevation MI and severe aortic stenosis

Nobuyuki Enzan, Takaki Tsutsumi, Yoshihiro Imamura, Akira Yamada

Annual Meeting of the European-Society-of-Cardiology (ESC) 2014年8月31日

共同研究・競争的資金等の研究課題

オミクス解析を用いた心不全の遺伝的基盤・新規バイオマーカー・創薬ターゲットの解明

日本学術振興会科学研究費助成事業若手研究若手研究 2023年4月 - 2026年3月

円山信之

円山信之

基本情報

研究キーワード

研究分野

経歴

学歴

受賞

論文

MISC

講演・口頭発表等

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧