論文

査読有り
2015年11月

Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis

NEUROLOGICAL SCIENCES
  • Akitoshi Taniguchi
  • ,
  • Hitoshi Mochizuki
  • ,
  • Shigeki Nagamachi
  • ,
  • Yuka Ebihara
  • ,
  • Nobuyuki Ishii
  • ,
  • Kazutaka Shiomi
  • ,
  • Masamitsu Nakazato

36
11
開始ページ
2117
終了ページ
2120
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10072-015-2323-x
出版者・発行元
SPRINGER-VERLAG ITALIA SRL

In previous studies of human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), areas of slow blood flow in the spinal cord were related to pathological changes. While the pathological changes in the brain are milder than those in the spinal cord, they are also more significant in sites with slow blood flow. In this study, we investigated brain glucose metabolism in slow blood flow areas using fluorine-18 fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). Clinical features and brain F-18-FDG-PET parameters were analyzed in six patients with HAM/TSP. For comparison of PET data, eight healthy volunteers were enrolled as normal controls (NLs). Glucose metabolism in the watershed areas of the middle and posterior cerebral arteries, as compared with that in the occipital lobes as a control, was significantly lower in HAM/TSP patients than in NLs. This result confirmed the relationship between slow blood flow areas and hypometabolism in HAM/TSP, and is consistent with previous findings that pathological changes are accentuated in sites with slow blood flow.

リンク情報
DOI
https://doi.org/10.1007/s10072-015-2323-x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26156876
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000364022100018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s10072-015-2323-x
  • ISSN : 1590-1874
  • eISSN : 1590-3478
  • PubMed ID : 26156876
  • Web of Science ID : WOS:000364022100018

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