論文

査読有り 国際誌
2020年2月24日

Calcium Wave Promotes Cell Extrusion.

Current biology : CB
  • Yasuto Takeuchi
  • ,
  • Rika Narumi
  • ,
  • Ryutaro Akiyama
  • ,
  • Elisa Vitiello
  • ,
  • Takanobu Shirai
  • ,
  • Nobuyuki Tanimura
  • ,
  • Keisuke Kuromiya
  • ,
  • Susumu Ishikawa
  • ,
  • Mihoko Kajita
  • ,
  • Masazumi Tada
  • ,
  • Yukinari Haraoka
  • ,
  • Yuki Akieda
  • ,
  • Tohru Ishitani
  • ,
  • Yoichiro Fujioka
  • ,
  • Yusuke Ohba
  • ,
  • Sohei Yamada
  • ,
  • Yoichiroh Hosokawa
  • ,
  • Yusuke Toyama
  • ,
  • Takaaki Matsui
  • ,
  • Yasuyuki Fujita

30
4
開始ページ
670
終了ページ
681
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cub.2019.11.089

When oncogenic transformation or apoptosis occurs within epithelia, the harmful or dead cells are apically extruded from tissues to maintain epithelial homeostasis. However, the underlying molecular mechanism still remains elusive. In this study, we first show, using mammalian cultured epithelial cells and zebrafish embryos, that prior to apical extrusion of RasV12-transformed cells, calcium wave occurs from the transformed cell and propagates across the surrounding cells. The calcium wave then triggers and facilitates the process of extrusion. IP3 receptor, gap junction, and mechanosensitive calcium channel TRPC1 are involved in calcium wave. Calcium wave induces the polarized movement of the surrounding cells toward the extruding transformed cells. Furthermore, calcium wave facilitates apical extrusion, at least partly, by inducing actin rearrangement in the surrounding cells. Moreover, comparable calcium propagation also promotes apical extrusion of apoptotic cells. Thus, calcium wave is an evolutionarily conserved, general regulatory mechanism of cell extrusion.

リンク情報
DOI
https://doi.org/10.1016/j.cub.2019.11.089
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32004455
ID情報
  • DOI : 10.1016/j.cub.2019.11.089
  • PubMed ID : 32004455

エクスポート
BibTeX RIS