Nobuyuki Okamura Last updated: Oct 2, 2018 at 14:04
Academic & Professional Experience
Apr 2016
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Today
Professor, Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University
Published Papers
Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Kazuhiko Yanai
Frontiers in Neuroscience 12 Aug 2018
© 2018 Harada, Okamura, Furumoto and Yanai. Neurodegenerative diseases characterized by pathological protein accumulation in cells are termed "proteinopathies." Although various protein aggregates share cross-β-sheet structures, actual conformatio...
Nobuyuki Okamura, Nobuyuki Okamura, Ryuichi Harada, Aiko Ishiki, Akio Kikuchi, Tadaho Nakamura, Yukitsuka Kudo
Clinical and Translational Imaging 6 305-316 Aug 2018
© 2018, The Author(s). Purpose: To provide an overview on positron emission tomography (PET) imaging of tau pathology in Alzheimer’s disease (AD) and other neurodegenerative disorders. Results: Different classes of tau tracers such as flortaucipir...
Yoko Shigemoto, Yoko Shigemoto, Daichi Sone, Daichi Sone, Etsuko Imabayashi, Norihide Maikusa, Nobuyuki Okamura, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Masayo Ogawa, Harumasa Takano, Harumasa Takano, Yuma Yokoi, Masuhiro Sakata, Tadashi Tsukamoto, Koichi Kato, Noriko Sato, Hiroshi Matsuda
Frontiers in Aging Neuroscience 10 Jul 2018
© 2018 Shigemoto, Sone, Imabayashi, Maikusa, Okamura, Furumoto, Kudo, Ogawa, Takano, Yokoi, Sakata, Tsukamoto, Kato, Sato and Matsuda. The recent advent of tau-specific positron emission tomography (PET) has enabled in vivo assessment of tau patho...
Jingyun Chen, Yi Li, Elizabeth Pirraglia, Nobuyuki Okamura, Henry Rusinek, Henry Rusinek, Mony J. de Leon
European Journal of Nuclear Medicine and Molecular Imaging 45 1596-1604 Jul 2018
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Off-target binding in the reference region is a challenge for recent tau tracers18F-AV-1451 and18F-THK5351. The conventional standardized uptake value ratio (SUVR) method reli...
Konstantinos Chiotis, Per Stenkrona, Ove Almkvist, Ove Almkvist, Ove Almkvist, Vladimir Stepanov, Daniel Ferreira, Ryosuke Arakawa, Akihiro Takano, Eric Westman, Andrea Varrone, Nobuyuki Okamura, Nobuyuki Okamura, Hitoshi Shimada, Makoto Higuchi, Christer Halldin, Agneta Nordberg, Agneta Nordberg
European Journal of Nuclear Medicine and Molecular Imaging 45 1605-1617 Jul 2018
© 2018, The Author(s). Purpose: Several tau PET tracers have been developed, but it remains unclear whether they bind to the same molecular target on the heterogeneous tau pathology. In this study we evaluated the binding of two chemically differe...
Matthias Brendel, Behrooz H. Yousefi, Behrooz H. Yousefi, Tanja Blume, Michael Herz, Carola Focke, Maximilian Deussing, Finn Peters, Simon Lindner, Barbara von Ungern-Sternberg, Alexander Drzezga, Peter Bartenstein, Peter Bartenstein, Christian Haass, Christian Haass, Christian Haass, Nobuyuki Okamura, Jochen Herms, Jochen Herms, Igor Yakushev, Igor Yakushev, Axel Rominger, Axel Rominger
Frontiers in Aging Neuroscience 10 Jun 2018
© 2018 Brendel, Yousefi, Blume, Herz, Focke, Deussing, Peters, Lindner, von Ungern-Sternberg, Drzezga, Bartenstein, Haass, Okamura, Herms, Yakushev and Rominger. Positron-emission-tomography (PET) imaging of tau pathology has facilitated developme...
Ryuichi Harada, Ryuichi Harada, Aiko Ishiki, Hideaki Kai, Naomi Sato, Katsutoshi Furukawa, Katsutoshi Furukawa, Shozo Furumoto, Tetsuro Tago, Naoki Tomita, Shoichi Watanuki, Kotaro Hiraoka, Yoichi Ishikawa, Yoshihito Funaki, Tadaho Nakamura, Takeo Yoshikawa, Ren Iwata, Manabu Tashiro, Hironobu Sasano, Tetsuyuki Kitamoto, Kazuhiko Yanai, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo, Nobuyuki Okamura, Nobuyuki Okamura
Journal of Nuclear Medicine 59 671-674 Apr 2018
� Copyright 2018 SNMMI; all rights reserved. Clinical PET studies using18F-THK5351 have demonstrated significant tracer retention in sites susceptible to tau burden in Alzheimer disease (AD). However, the in vivo PET signal to reflect tau aggregat...
Soichiro Shimizu, Etsuko Imabayashi, Naoto Takenoshita, Nobuyuki Okamura, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Hiroshi Matsuda, Haruo Hanyu
Geriatrics and Gerontology International 18 501-502 Mar 2018
Matthias Brendel, Sonja Schönecker, Günter Höglinger, Günter Höglinger, Simon Lindner, Joachim Havla, Joachim Havla, Janusch Blautzik, Julia Sauerbeck, Guido Rohrer, Christian Zach, Franziska Vettermann, Anthony E. Lang, Lawrence Golbe, Georg Nübling, Peter Bartenstein, Katsutoshi Furukawa, Aiko Ishiki, Kai Bötzel, Adrian Danek, Nobuyuki Okamura, Johannes Levin, Johannes Levin, Axel Rominger
Frontiers in Aging Neuroscience 9 Jan 2018
© 2018 Brendel, Schönecker, Höglinger, Lindner, Havla, Blautzik, Sauerbeck, Rohrer, Zach, Vettermann, Lang, Golbe, Nübling, Bartenstein, Furukawa, Ishiki, Bötzel, Danek, Okamura, Levin and Rominger. Progressive supranuclear palsy (PSP) is a neurod...
Hyon Lee, Seongho Seo, Sang Yoon Lee, Hye Jin Jeong, Sung Ho Woo, Kyoung Min Lee, Yeong Bae Lee, Kee Hyung Park, Jae Hyeok Heo, Cindy W. Yoon, Jae Myeong Kang, Jaelim Cho, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Kazuhiko Yanai, Duk L. Na, Duk L. Na, Tatsuo Ido, Victor L. Villemagne, Victor L. Villemagne, Young Noh, Young Noh
Alzheimer Disease and Associated Disorders 32 62-69 Jan 2018
© 2017 Wolters Kluwer Health, Inc. All rights reserved. Background: Semantic variant primary progressive aphasia (svPPA) has been associated with a variety of proteinopathies, mainly transactive response DNA-binding protein, but also with tau and ...
Laetitia Lemoine, Per Göran Gillberg, Marie Svedberg, Vladimir Stepanov, Zhisheng Jia, Jinghai Huang, Sangram Nag, He Tian, Bernardino Ghetti, Nobuyuki Okamura, Makoto Higuchi, Christer Halldin, Agneta Nordberg, Agneta Nordberg
Alzheimer's Research and Therapy 9 Dec 2017
© 2017 The Author(s). Background: The aim of this study was to compare the binding properties of several tau positron emission tomography tracers - THK5117, THK5351, T807 (also known as AV1451; flortaucipir), and PBB3 - head to head in the same hu...
Sang Ju Lee, Seung Jun Oh, Eun Hye Cho, Da Hye Kim, Shozo Furumoto, Nobuyuki Okamura, Jae Seung Kim
Journal of Radioanalytical and Nuclear Chemistry 314 1587-1593 Dec 2017
© 2017, Akadémiai Kiadó, Budapest, Hungary. [ 18 F]THK-5351, a new candidate for tau protein imaging, is based on an aryl quinoline structure. We report the full automatic synthesis using disposable cassettes under pH controlled [ 18 F]fluorinatio...
Tobey J. Betthauser, Tobey J. Betthauser, Paul A. Ellison, Dhanabalan Murali, Patrick J. Lao, Patrick J. Lao, Todd E. Barnhart, Shozo Furumoto, Nobuyuki Okamura, Sterling C. Johnson, Sterling C. Johnson, Sterling C. Johnson, Jonathan W. Engle, Robert J. Nickles, Bradley T. Christian, Bradley T. Christian
Applied Radiation and Isotopes 130 230-237 Dec 2017
© 2017 Elsevier Ltd This work characterizes the radiochemical synthesis, purification, and formulation of [ 18 F]THK-5351, a tau PET radioligand, and develops an automated radiosynthesis routine (ELIXYS, Sofie Biosciences). Nucleophilic radiofluor...
Fumito Naganuma, Fumito Naganuma, Tadaho Nakamura, Tadaho Nakamura, Takeo Yoshikawa, Tomomitsu Iida, Yamato Miura, Anikó Kárpáti, Takuro Matsuzawa, Atushi Yanai, Asuka Mogi, Takatoshi Mochizuki, Nobuyuki Okamura, Nobuyuki Okamura, Kazuhiko Yanai
Scientific Reports 7 Dec 2017
© 2017 The Author(s). Histamine is a neurotransmitter that regulates diverse physiological functions including the sleep-wake cycle. Recent studies have reported that histaminergic dysfunction in the brain is associated with neuropsychiatric disor...
Jae Myeong Kang, Sang Yoon Lee, Seongho Seo, Hye Jin Jeong, Sung Ho Woo, Hyon Lee, Yeong Bae Lee, Byeong Kil Yeon, Dong Hoon Shin, Kee Hyung Park, Hyejin Kang, Nobuyuki Okamura, Shozo Furumoto, Kazuhiko Yanai, Kazuhiko Yanai, Victor L. Villemagne, Victor L. Villemagne, Joon Kyung Seong, Joon Kyung Seong, Duk L. Na, Duk L. Na, Tatsuo Ido, Jaelim Cho, Kyoung Min Lee, Young Noh, Young Noh
Neurobiology of Aging 59 210-219 Nov 2017
© 2017 Elsevier Inc. This study aims to evaluate the clinical validity of [ 18 F]THK5351 positron emission tomography (PET) for the assessment of disease progression an d symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 3...
Mony J. De Leon, Yi Li, Nobuyuki Okamura, Wai H. Tsui, Les A. Saint-Louis, Lidia Glodzik, Lidia Glodzik, Ricardo S. Osorio, Juan Fortea, Tracy Butler, Elizabeth Pirraglia, Silvia Fossati, Silvia Fossati, Hee Jin Kim, Hee Jin Kim, Roxana O. Carare, Maiken Nedergaard, Maiken Nedergaard, Helene Benveniste, Henry Rusinek
Journal of Nuclear Medicine 58 1471-1476 Sep 2017
Copyright © 2017 by the Society of Nuclear Medicine and Molecular Imaging. Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is involved in the pathophysiology of Alzheimer disease (AD) comes primarily from rodent...
Ing Tsung Hsiao, Ing Tsung Hsiao, Ing Tsung Hsiao, Kun Ju Lin, Kun Ju Lin, Kun Ju Lin, Kuo Lun Huang, Chin Chang Huang, Han Shiuan Chen, Shiaw Pyng Wey, Shiaw Pyng Wey, Tzu Chen Yen, Tzu Chen Yen, Tzu Chen Yen, Nobuyuki Okamura, Nobuyuki Okamura, Jung Lung Hsu, Jung Lung Hsu
Journal of Nuclear Medicine 58 1498-1503 Sep 2017
Copyright © 2017 by the Society of Nuclear Medicine and Molecular Imaging. 18 F-THK-5351 is a novel radiotracer that demonstrates high binding selectivity and affinity for tau pathology and exhibits better pharmacokinetics in the living brain than...
Yuma Arakawa, Yinghwey Nai, Miho Shidahara, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe
Journal of Nuclear Medicine 58 1285-1292 Aug 2017
© Copyright 2017 by the Society of Nuclear MeDicine and Molecular Imaging. Our study aimed to develop a method to mathematically preDict the kinetic parameters K1 (influx rate constant), k2 (efflux rate constant), and BPND (nonDisplaceable binDing...
Miho Shidahara, Miho Shidahara, Benjamin A. Thomas, Benjamin A. Thomas, Nobuyuki Okamura, Masanobu Ibaraki, Keisuke Matsubara, Senri Oyama, Yoichi Ishikawa, Shoichi Watanuki, Ren Iwata, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe
Annals of Nuclear Medicine 31 563-569 Jun 2017
© 2017, The Japanese Society of Nuclear Medicine. Purpose: To suppress partial volume effect (PVE) in brain PET, there have been many algorithms proposed. However, each methodology has different property due to its assumption and algorithms. Our a...
Tobey J. Betthauser, Tobey J. Betthauser, Patrick J. Lao, Patrick J. Lao, Dhanabalan Murali, Todd E. Barnhart, Shozo Furumoto, Nobuyuki Okamura, Charles K. Stone, Sterling C. Johnson, Sterling C. Johnson, Bradley T. Christian, Bradley T. Christian
Journal of Nuclear Medicine 58 996-1002 Jun 2017
© 2017 by the Society of Nuclear Medicine and Molecular Imaging. This study compared the in vivo imaging characteristics of tau PET ligands 18 F-THK-5351 and 18 F-THK-5317 in the context of Alzheimer disease (AD). Additionally, reference tissue di...
Okamura N, Yanai K
Nature reviews. Neurology 13(4) 197-198 Apr 2017 [Invited]
Kok Pin Ng, Kok Pin Ng, Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Joseph Therriault, Min Su Kang, Monica Shin, Marie Christine Guiot, Qi Guo, Ryuichi Harada, Robert A. Comley, Gassan Massarweh, Jean Paul Soucy, Nobuyuki Okamura, Serge Gauthier, Pedro Rosa-Neto, Pedro Rosa-Neto, Pedro Rosa-Neto, Pedro Rosa-Neto
Alzheimer's Research and Therapy 9 Mar 2017
© 2017 The Author(s). Background: 18 F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18 F-THK5351 retention in brain regions thought to contain negligible concentrati...
Shozo Furumoto, Shozo Furumoto, Tetsuro Tago, Tetsuro Tago, Ryuichi Harada, Yukitsuka Kudo, Nobuyuki Okamura
Current Alzheimer Research 14 178-185 Feb 2017
© 2017 Bentham Science Publishers. Alzheimer’s disease is the most common form of dementia among older people. Misfolding and aggregation of proteins (amyloid-β and tau) in the brain is the primary cause of neurodegeneration in the disease. Non-in...
Ramesh Neelamegam, Ramesh Neelamegam, Daniel L. Yokell, Daniel L. Yokell, Peter A. Rice, Shozo Furumoto, Yukitsuka Kudo, Nobuyuki Okamura, Georges El Fakhri, Georges El Fakhri
Journal of Labelled Compounds and Radiopharmaceuticals 60 140-146 Feb 2017
Copyright © 2016 John Wiley & Sons, Ltd. The radiotracer, [ 18 F]-THK-5351, is a highly selective and high-binding affinity PET imaging agent for aggregates of hyper-phosphorylated tau protein. Our report is a simplified 1-pot, 2-step radiosynth...
Daichi Sone, Daichi Sone, Etsuko Imabayashi, Norihide Maikusa, Nobuyuki Okamura, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Masayo Ogawa, Harumasa Takano, Yuma Yokoi, Masuhiro Sakata, Tadashi Tsukamoto, Koichi Kato, Hiroshi Matsuda
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 9 35-40 Jan 2017
© 2017 The Authors Introduction Molecular imaging and selective hippocampal subfield atrophy are a focus of recent Alzheimer's disease (AD) research. Here, we investigated correlations between molecular imaging and hippocampal subfields in early A...
Ryuichi Harada, Shozo Furumoto, Tetsuro Tago, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Ren Iwata, Manabu Tashiro, Hiroyuki Arai, Kazuhiko Yanai, Kazuhiko Yanai, Yukitsuka Kudo, Yukitsuka Kudo, Nobuyuki Okamura, Nobuyuki Okamura, Nobuyuki Okamura
European Journal of Nuclear Medicine and Molecular Imaging 44 177 Jan 2017
© 2016, Springer-Verlag Berlin Heidelberg. The name of Katsutoshi Furukawa was swapped in the original version of this paper. Correct name is presented here.
Nobuyuki Okamura, Ryuichi Harada, Shozo Furumoto, Tadaho Nakamura, Kazuhiko Yanai, Yukitsuka Kudo
Folia Pharmacologica Japonica 150 172-176 Jan 2017
A. Ishiki, R. Harada, N. Okamura, N. Okamura, N. Tomita, C. C. Rowe, V. L. Villemagne, V. L. Villemagne, K. Yanai, Y. Kudo, H. Arai, S. Furumoto, M. Tashiro, K. Furukawa, K. Furukawa
European Journal of Neurology 24 130-136 Jan 2017
© 2016 EAN Background and purpose: Visualization of pathogenic protein aggregates is crucial to elucidate pathomechanisms and to make an accurate diagnosis in many neurodegenerative conditions. Aggregates of the microtubule-binding protein, tau, a...
Akio Kikuchi, Nobuyuki Okamura, Takafumi Hasegawa, Ryuichi Harada, Shoichi Watanuki, Yoshihito Funaki, Kotaro Hiraoka, Toru Baba, Naoto Sugeno, Ryuji Oshima, Shun Yoshida, Junpei Kobayashi, Michinori Ezura, Michiko Kobayashi, Ohito Tano, Shunji Mugikura, Ren Iwata, Aiko Ishiki, Katsutoshi Furukawa, Hiroyuki Arai, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Atsushi Takeda, Masashi Aoki
Neurology 87 2309-2316 Nov 2016
© 2016 American Academy of Neurology. Objective: To determine whether 18 F-THK5351 PET can be used to visualize tau deposits in brain lesions in live patients with corticobasal syndrome (CBS). Methods: We evaluated the in vitro binding of 3 H-THK5...
Ryuichi Harada, Shozo Furumoto, Tetsuro Tago, Furukawa Katsutoshi, Aiko Ishiki, Naoki Tomita, Ren Iwata, Manabu Tashiro, Hiroyuki Arai, Kazuhiko Yanai, Kazuhiko Yanai, Yukitsuka Kudo, Yukitsuka Kudo, Nobuyuki Okamura, Nobuyuki Okamura, Nobuyuki Okamura
European Journal of Nuclear Medicine and Molecular Imaging 43 2211-2218 Nov 2016
© 2016, Springer-Verlag Berlin Heidelberg. Purpose: 18 F-THK5351 is a novel radiotracer developed for in vivo imaging of tau pathology in the brain. For the quantitative assessment of tau deposits in the brain, it is important that the radioacti...
Shozo Furumoto, Shozo Furumoto, Tetsuro Tago, Tetsuro Tago, Ryuichi Harada, Yukitsuka Kudo, Nobuyuki Okamura
Current Alzheimer Research 13 Oct 2016
© 2016 Bentham Science Publishers. Alzheimer’s disease is the most common form of dementia among older people. Misfolding and aggregation of proteins (amyloid-β and tau) in the brain is the primary cause of neurodegeneration in the disease. Non-in...
Nobuyuki Okamura, Nobuyuki Okamura, Ryuichi Harada, Katsutoshi Furukawa, Shozo Furumoto, Tetsuro Tago, Kazuhiko Yanai, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
Ageing Research Reviews 30 107-113 Sep 2016
© 2016 Elsevier B.V. Alzheimer's disease and other neurodegenerative dementias belong to the family of tauopathies. These diseases are characterized by the deposition of insoluble tau aggregates possessing an enriched β-sheet structure. In vivo im...
Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Yuta Onaka, Haruka Saito, Tomoko Nakamichi, Kazunari Hara, Yusuke Kusano, Masamune Ebara, Yuki Arata, Miku Sakota, Isabelle Miyazawa, Tomoko Totsune, Shoji Okinaga, Nobuyuki Okamura, Nobuyuki Okamura, Yukitsuka Kudo, Hiroyuki Arai
Ageing Research Reviews 30 1-3 Sep 2016
© 2016 Elsevier B.V. It is well known that the brain is one of the organs particularly affected by aging in terms of function, relative to the gastrointestinal tract and liver, which exhibit less functional decline. There is also a wide range of a...
Sonja Schönecker, Matthias Brendel, Marion Huber, Christian Vollmar, Hans Juergen Huppertz, Stefan Teipel, Stefan Teipel, Nobuyuki Okamura, Johannes Levin, Johannes Levin, Axel Rominger, Adrian Danek
BMC Neurology 16 Aug 2016
© 2016 The Author(s). Background: Alzheimer's disease (AD) is the most common cause of dementia in the elderly. The possibility of disease-modifying strategies has evoked a need for early and accurate diagnosis. To improve the accuracy of the clin...
Samuel N. Lockhart, Suzanne L. Baker, Suzanne L. Baker, Nobuyuki Okamura, Katsutoshi Furukawa, Aiko Ishiki, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo, Ryuichi Harada, Naoki Tomita, Kotaro Hiraoka, Shoichi Watanuki, William J. Jagust, William J. Jagust
PLoS ONE 11 Jun 2016
© 2016 Lockhart et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ar...
Matthias Brendel, Anna Jaworska, Federico Probst, Felix Overhoff, Viktoria Korzhova, Simon Lindner, Janette Carlsen, Peter Bartenstein, Peter Bartenstein, Ryuichi Harada, Yukitsuka Kudo, Christian Haass, Christian Haass, Christian Haass, Fred Van Leuven, Nobuyuki Okamura, Jochen Herms, Jochen Herms, Axel Rominger, Axel Rominger
Journal of Nuclear Medicine 57 792-798 May 2016
Abnormal accumulation of tau aggregates in the brain is one of the hallmarks of Alzheimer disease neuropathology. We visualized tau deposition in vivo with the previously developed 2-arylquinoline derivative 18 F-THK5117 using small-animal PET in ...
Tetsuro Tago, Tetsuro Tago, Shozo Furumoto, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Hajime Adachi, Hajime Adachi, Yoichi Ishikawa, Kazuhiko Yanai, Kazuhiko Yanai, Ren Iwata, Yukitsuka Kudo
Journal of Nuclear Medicine 57 608-614 Apr 2016
COPYRIGHT © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc. Abnormal deposition of amyloid-β and hyperphosphorylated tau protein in the brain are the pathologic hallmark of Alzheimer disease (AD). Noninvasive detection of the l...
Ryuichi Harada, Shozo Furumoto, Takeo Yoshikawa, Yoichi Ishikawa, Katsuhiko Shibuya, Nobuyuki Okamura, Nobuyuki Okamura, Kiichi Ishiwata, Ren Iwata, Kazuhiko Yanai, Kazuhiko Yanai
Journal of Nuclear Medicine 57 634-639 Apr 2016
COPYRIGHT © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc. Macromolecules such as proteins are attracting increasing interest for molecular imaging. We previously proposed a novel strategy for preparing macromolecules labeled ...
Tetsuro Tago, Tetsuro Tago, Shozo Furumoto, Shozo Furumoto, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Hajime Adachi, Hajime Adachi, Yoichi Ishikawa, Kazuhiko Yanai, Ren Iwata, Yukitsuka Kudo
Molecular Imaging and Biology 18 258-266 Apr 2016
© 2015, World Molecular Imaging Society. Purpose: Noninvasive imaging of tau and amyloid-β pathologies would facilitate diagnosis of Alzheimer’s disease (AD). Recently, we have developed [ 18 F]THK-5105 for selective detection of tau pathology by ...
Yukitsuka Kudo, Shozo Furumoto, Ryuichi Harada, Nobuyuki Okamura
Nihon rinsho. Japanese journal of clinical medicine 74 404-409 Mar 2016
Several promising tau imaging probes have been developed by Tohoku University ([18F]THK series), National Institute of Radiological Sciences([11C] PBB3), Eli Lilly ([18F]T807), and Hoffman-La Roche ([18F] R06958948). In this paper we discussed som...
Hiroyuki Arai, Katsutoshi Furukawa, Naoki Tomita, Aiko Ishiki, Nobuyuki Okamura, Yukitsuka Kudo
Nihon rinsho. Japanese journal of clinical medicine 74 411-416 Mar 2016
Development of symptomatic treatment of Alzheimer s disease by cholinesterase inhibitors like donepezil was successful. However, it is a disappointment that development of disease-modifying drugs such as anti-amyloid drug based on amyloid-cascade ...
Ryuichi Harada, Nobuyuki Okamura, Nobuyuki Okamura, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Tetsuro Tago, Kotaro Hiraoka, Shoichi Watanuki, Miho Shidahara, Miho Shidahara, Masayasu Miyake, Yoichi Ishikawa, Rin Matsuda, Akie Inami, Takeo Yoshikawa, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo, Yukitsuka Kudo
Journal of Nuclear Medicine 57 208-214 Feb 2016
© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc. Imaging of neurofibrillary pathology in the brain helps in diagnosing dementia, tracking disease progression, and evaluating the therapeutic efficacy of antidementia drugs. The ...
Victor L. Villemagne, Victor L. Villemagne, Victor L. Villemagne, Nobuyuki Okamura
Current Opinion in Neurobiology 36 43-51 Feb 2016
© 2015 Elsevier Ltd. In vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as Alzheimer's disease, progressive supran...
Ryuichi Harada, Nobuyuki Okamura, Nobuyuki Okamura, Shozo Furumoto, Tetsuro Tago, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo, Yukitsuka Kudo
Biomolecules 6 2-15 Jan 2016
© 2016 by the authors; licensee MDPI, Basel, Switzerland. Tau deposition is one of the neuropathological hallmarks in Alzheimer’s disease as well as in other neurodegenerative disorders called tauopathies. Recent efforts to develop selective tau r...
Victor L. Villemagne, Victor L. Villemagne, Victor L. Villemagne, Nobuyuki Okamura, Christopher C. Rowe, Christopher C. Rowe
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 4 39-42 Jan 2016
© 2016 The Authors. In vivo imaging of tau deposits is providing a better understanding of the temporal and spatial tau deposition in the brain, allowing a more comprehensive insight into the causes, diagnoses, and potentially treatment of tauopat...
Aiko Ishiki, Nobuyuki Okamura, Nobuyuki Okamura, Katsutoshi Furukawa, Shozo Furumoto, Ryuichi Harada, Naoki Tomita, Kotaro Hiraoka, Shoichi Watanuki, Yoichi Ishikawa, Tetsuro Tago, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Yukitsuka Kudo, Hiroyuki Arai
PLoS ONE 10 Oct 2015
© 2015 Ishiki et al This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are c...
Kotaro Hiraoka, Wataru Narita, Hirokazu Kikuchi, Toru Baba, Shigenori Kanno, Osamu Iizuka, Manabu Tashiro, Shozo Furumoto, Shozo Furumoto, Nobuyuki Okamura, Katsutoshi Furukawa, Hiroyuki Arai, Ren Iwata, Etsuro Mori, Kazuhiko Yanai, Kazuhiko Yanai
Journal of the Neurological Sciences 356 124-128 Sep 2015
© 2015 Elsevier B.V. Abstract Objectives In previous studies, patients with idiopathic normal-pressure hydrocephalus (iNPH) occasionally showed Alzheimer's pathology in frontal lobe cortical biopsy during cerebrospinal fluid shunt surgery or intra...
Miho Shidahara, Miho Shidahara, Hiroshi Watabe, Manabu Tashiro, Nobuyuki Okamura, Shozo Furumoto, Shoichi Watanuki, Katsutoshi Furukawa, Yuma Arakawa, Yoshihito Funaki, Ren Iwata, Kohsuke Gonda, Yukitsuka Kudo, Hiroyuki Arai, Kiichi Ishiwata, Kazuhiko Yanai
Nuclear Medicine and Biology 42 734-744 Sep 2015
© 2015 Elsevier Inc.. Introduction: The purpose of this study was to compare two amyloid imaging agents, [ 11 C]BF227 and [ 18 F]FACT (derivative from [ 11 C]BF227) through quantitative pharmacokinetics analysis in human brain. Methods: Positron e...
Laetitia Lemoine, Laure Saint-Aubert, Amelia Marutle, Gunnar Antoni, Gunnar Antoni, Jonas P. Eriksson, Jonas P. Eriksson, Bernardino Ghetti, Nobuyuki Okamura, Inger Nennesmo, Per Göran Gillberg, Agneta Nordberg, Agneta Nordberg
Acta neuropathologica communications 3 40 Jul 2015
INTRODUCTION: The accumulation of neurofibrillary tangles, composed of aggregated hyperphosphorylated tau protein, starts spreading early in specific regions in the course of Alzheimer's disease (AD), correlating with the progression of memory dy...
Ryuichi Harada, Nobuyuki Okamura, Nobuyuki Okamura, Shozo Furumoto, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Kotaro Hiraoka, Shoichi Watanuki, Miho Shidahara, Miho Shidahara, Masayasu Miyake, Yoichi Ishikawa, Rin Matsuda, Akie Inami, Takeo Yoshikawa, Tetsuro Tago, Yoshihito Funaki, Ren Iwata, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo, Yukitsuka Kudo
European Journal of Nuclear Medicine and Molecular Imaging 42 1052-1061 Jun 2015
© 2015, Springer-Verlag Berlin Heidelberg. Purpose: Visualization of the spatial distribution of neurofibrillary tangles would help in the diagnosis, prevention and treatment of dementia. The purpose of the study was to evaluate the clinical utili...
Conference Activities & Talks
Nobuyuki Okamura, K. Yanai
IFMBE Proceedings 1 Dec 2009
Depositions of amyloid plaques, neurofibrillary tangles and subsequent neurotransmitter deficits are neuropathological characteristics of Alzheimer's disease. Non-invasive monitoring of these changes in the brain is potentially useful for early di...
Research Grants & Projects
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010 Investigator(s): Nobuyuki OKAMURA
Noninvasive visualization of amyloid-ss (Ass) and tau deposits in the living brain will contribute to a better understanding of the pathophysiology of Alzheimer's disease (AD). Although in vivo Ass imaging probes for positron emission tomography (...
