論文

査読有り 国際誌
2021年

18F-THK5351 Positron Emission Tomography Imaging in Neurodegenerative Tauopathies.

Frontiers in aging neuroscience
  • Michinori Ezura
  • Akio Kikuchi
  • Nobuyuki Okamura
  • Aiko Ishiki
  • Takafumi Hasegawa
  • Ryuichi Harada
  • Shoichi Watanuki
  • Yoshihito Funaki
  • Kotaro Hiraoka
  • Toru Baba
  • Naoto Sugeno
  • Shun Yoshida
  • Junpei Kobayashi
  • Michiko Kobayashi
  • Ohito Tano
  • Shun Ishiyama
  • Takaaki Nakamura
  • Ichiro Nakashima
  • Shunji Mugikura
  • Ren Iwata
  • Yasuyuki Taki
  • Katsutoshi Furukawa
  • Hiroyuki Arai
  • Shozo Furumoto
  • Manabu Tashiro
  • Kazuhiko Yanai
  • Yukitsuka Kudo
  • Atsushi Takeda
  • Masashi Aoki
  • 全て表示

13
開始ページ
761010
終了ページ
761010
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fnagi.2021.761010

Introduction: We aimed to determine whether in vivo tau deposits and monoamine oxidase B (MAO-B) detection using 18F-THK5351 positron emission tomography (PET) can assist in the differential distribution in patients with corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and Alzheimer's disease (AD) and whether 18F-THK5351 retention of lesion sites in CBS and PSP can correlate with clinical parameters. Methods: 18F-THK5351 PET was performed in 35 participants, including 7, 9, and 10 patients with CBS, PSP, and AD, respectively, and 9 age-matched normal controls. In CBS and PSP, cognitive and motor functions were assessed using the Montreal Cognitive Assessment, Addenbrooke's Cognitive Examination-Revised, and Frontal Assessment Battery, Unified Parkinson's Disease Rating Scale Motor Score, and PSP Rating Scale. Results: 18F-THK5351 retention was observed in sites susceptible to disease-related pathologies in CBS, PSP, and AD. 18F-THK5351 uptake in the precentral gyrus clearly differentiated patients with CBS from those with PSP and AD. Furthermore, 18F-THK5351 uptake in the inferior temporal gyrus clearly differentiated patients with AD from those with CBS and PSP. Regional 18F-THK5351 retention was associated with the cognitive function in CBS and PSP. Conclusion: Measurement of the tau deposits and MAO-B density in the brain using 18F-THK5351 may be helpful for the differential diagnosis of tauopathies and for understanding disease stages.

リンク情報
DOI
https://doi.org/10.3389/fnagi.2021.761010
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34912209
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668184
ID情報
  • DOI : 10.3389/fnagi.2021.761010
  • PubMed ID : 34912209
  • PubMed Central 記事ID : PMC8668184

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