2016年4月22日
Wewakazole B, a Cytotoxic Cyanobactin from the Cyanobacterium Moorea producens Collected in the Red Sea.
Journal of natural products
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- 巻
- 79
- 号
- 4
- 開始ページ
- 1213
- 終了ページ
- 8
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1021/acs.jnatprod.6b00051
A mass spectrometry (MS)-guided isolation has led to the purification of a new cyanobactin, wewakazole B (1), along with the known compound curacin D from a Red Sea Moorea producens. The planar structure of 1 was elucidated using a combination of NMR and MS techniques. After ozonolysis and acid hydrolysis, the absolute configurations of the amino acid components of 1 were determined by chiral-phase LC-MS and HPLC analyses. Notably, compound 1 exhibited cytotoxic activity toward human MCF7 breast cancer cells (IC50 = 0.58 μM) and human H460 lung cancer cells (IC50 = 1.0 μM) and was also found to be inactive in a siderophore assay.
- リンク情報
- ID情報
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- DOI : 10.1021/acs.jnatprod.6b00051
- ISSN : 0163-3864
- PubMed ID : 26980238
- Web of Science ID : WOS:000374915800073