Takao Nomura

Profile Information

Affiliation: Hokkaido University

Degree: 博士（理学）(北海道大学)

J-GLOBAL ID: 201501057208028208
researchmap Member ID: B000246053

Research Interests

Research Areas

Life sciences / Pharmaceuticals - chemistry and drug development /

Research History

Jan, 2022 - Present

特任講師, 北海道大学大学院薬学研究院
Sep, 2013 - Present

Faculty of Pharmaceutical Sciences, Hokkaido University
Apr, 2011 - Aug, 2013

Faculty of Science and Technology, Keio University
Sep, 2010 - Mar, 2011

Research Institute for Electronic Science, Hokkaido University

Education

Apr, 2007 - Mar, 2010

日本学術振興会特別研究員（DC１）
Oct, 2006 - Sep, 2009

Department of Chemistry, Graduate School of Science, Hokkaido University
Apr, 2005 - Sep, 2006

Faculty of Science, Hokkaido University
Apr, 2001 - Mar, 2005

Chemistry, School of Science, Hokkaido University

Papers

Application of Acoustic Ejection MS System to High-Throughput Screening for SARS-CoV-2 3CL Protease Inhibitors.

Tsukasa Hasegawa, Riyo M Imamura, Tateki Suzuki, Takao Hashiguchi, Takao Nomura, Satoko Otsuguro, Katsumi Maenaka, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa …

Chemical & pharmaceutical bulletin, 70(3) 199-201, Mar 1, 2022
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site.

Taishi Onodera, Shunsuke Kita, Yu Adachi, Saya Moriyama, Akihiko Sato, Takao Nomura, Shuhei Sakakibara, Takeshi Inoue, Takashi Tadokoro, Yuki Anraku …

Immunity, 54(10) 2385-2398, Oct 12, 2021
Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment.

Hirofumi Ohashi, Koichi Watashi, Wakana Saso, Kaho Shionoya, Shoya Iwanami, Takatsugu Hirokawa, Tsuyoshi Shirai, Shigehiko Kanaya, Yusuke Ito, Kwang Su Kim …

iScience, 24(4) 102367-102367, Apr 23, 2021
The tetramerization domain of the tree shrew p53 protein displays unique thermostability despite sharing high sequence identity with the human p53 protein.

Natsumi Nakagawa, Shuya Sakaguchi, Takao Nomura, Rui Kamada, James G Omichinski, Kazuyasu Sakaguchi

Biochemical and biophysical research communications, 521(3) 681-686, Jan 15, 2020 Peer-reviewed
Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells.

Wataru Kakuguchi, Takao Nomura, Tetsuya Kitamura, Satoko Otsuguro, Kazuhiro Matsushita, Masahiro Sakaitani, Katsumi Maenaka, Kanchu Tei

Cancer medicine, 7(12) 6269-6280, Dec, 2018 Peer-reviewed
A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis

Tokuda Eiichi, Nomura Takao, Ohara Shinji, Watanabe Seiji, Yamanaka Koji, Morisaki Yuta, Misawa Hidemi, Furukawa Yoshiaki

Biochimica et Biophysica Acta - Molecular Basis of Disease, 1864(6) 2119-2130, Jun 1, 2018 Peer-reviewed
A copper-deficient form of mutant Cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis.

Tokuda E, Nomura T, Ohara S, Watanabe S, Yamanaka K, Morisaki Y, Misawa H, Furukawa Y

Biochimica et biophysica acta, 1864(6 Pt A) 2119-2130, Jun, 2018 Peer-reviewed
Sez6l2 regulates phosphorylation of ADD and neuritogenesis.

Yaguchi H, Yabe I, Takahashi H, Watanabe M, Nomura T, Kano T, Matsumoto M, Nakayama KI, Watanabe M, Hatakeyama S

Biochemical and biophysical research communications, 494(1-2) 234-241, Dec, 2017 Peer-reviewed
Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILR alpha immune cell receptor

Atsushi Furukawa, Kosuke Kakita, Tomoki Yamada, Mikihiro Ishizuka, Jiro Sakamoto, Nanao Hatori, Naoyoshi Maeda, Fumina Ohsaka, Takashi Saitoh, Takao Nomura …

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(51) 21128-21136, Dec, 2017 Peer-reviewed
Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors

Takanori Matsumaru, Makoto Inai, Kana Ishigami, Toshiki Iwamatsu, Hiroshi Maita, Satoko Otsuguro, Takao Nomura, Akira Matsuda, Satoshi Ichikawa, Masahiro Sakaitani …

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27(10) 2144-2147, May, 2017 Peer-reviewed
Immunochemical characterization on pathological oligomers of mutant Cu/Znsuperoxide dismutase in amyotrophic lateral sclerosis

Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa …

MOLECULAR NEURODEGENERATION, 12(1) 2, Jan, 2017 Peer-reviewed
Synthesis and Th1-immunostimulatory activity of alpha-galactosylceramide analogues bearing a halogen-containing or selenium-containing acyl chain

Md. Imran Hossain, Shinya Hanashima, Takuto Nomura, Sebastien Lethu, Hiroshi Tsuchikawa, Michio Murata, Hiroki Kusaka, Shunsuke Kita, Katsumi Maenaka

BIOORGANIC & MEDICINAL CHEMISTRY, 24(16) 3687-3695, Aug, 2016 Peer-reviewed
Tetramer Formation of Tumor Suppressor Protein p53: Structure, Function, and Applications

Rui Kamada, Yu Toguchi, Takao Nomura, Toshiaki Imagawa, Kazuyasu Sakaguchi

BIOPOLYMERS, 106(4) 598-612, Jul, 2016 Peer-reviewed
Conformational Disorder of the Most Immature Cu, Zn-Superoxide Dismutase Leading to Amyotrophic Lateral Sclerosis

Yoshiaki Furukawa, Itsuki Anzai, Shuji Akiyama, Mizue Imai, Fatima Joy C. Cruz, Tomohide Saio, Kenichi Nagasawa, Takao Nomura, Koichiro Ishimori

JOURNAL OF BIOLOGICAL CHEMISTRY, 291(8) 4144-4155, Feb, 2016 Peer-reviewed
Intranuclear Aggregation of Mutant FUS/TLS as a Molecular Pathomechanism of Amyotrophic Lateral Sclerosis

Takao Nomura, Shoji Watanabe, Kumi Kaneko, Koji Yamanaka, Nobuyuki Nukina, Yoshiaki Furukawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(2) 1192-1202, Jan, 2014 Peer-reviewed
2P032 Aberrant monomer-dimer equilibrium of mutant SOD1 in ALS: Development of peptides probing protein quaternary structures(01B. Protein: Structure & Function,Poster)

Nomura Takao, Furukawa Yoshiaki

Seibutsu Butsuri, 53(1) S164, 2013
1P065 A new pathomechanism of amyotrophic lateral sclerosis regulated by aggregation of FUS/TLS protein(01C. Protein:Property,Poster)

Nomura Takao, Watanabe Shoji, Kaneko Kumi, Yamanaka Koji, Nukina Nobuyuki, Furukawa Yoshiaki

Seibutsu Butsuri, 53(1) S116, 2013
Post-aggregation Oxidation of Mutant Huntingtin Controls the Interactions between Aggregates

Yasushi Mitomi, Takao Nomura, Masaru Kurosawa, Nobuyuki Nukina, Yoshiaki Furukawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(41) 34764-34775, Oct, 2012 Peer-reviewed
2B1558 A mechanism controlling the morphologies of protein aggregates by "post-aggregation oxidation"(Proteins:Structure & Function II:Theory, Aggregation,Oral Presentation,The 50th Annual Meeting of the Biophysical Society of Japan)

Mitomi Yasushi, Nomura Takao, Kurosawa Masaru, Nukina Nobuyuki, Furukawa Yoshiaki

Seibutsu Butsuri, 52 S41, 2012
Probing Phenylalanine Environments in Oligomeric Structures with Pentafluorophenylalanine and Cyclohexylalanine

Takao Nomura, Rui Kamada, Issaku Ito, Koichi Sakamoto, Yoshiro Chuman, Koichiro Ishimori, Yasuyuki Shimohigashi, Kazuyasu Sakaguchi

BIOPOLYMERS, 95(6) 410-419, Jun, 2011 Peer-reviewed

Misc.

新型コロナウイルスに対するscFv化抗体の機能評価

染谷太陽, 谷秀顕, 安楽佑樹, 田聡, 福原秀雄, 福原秀雄, 野村尚生, 田所高志, 小野寺大志, 安達悠 …

日本蛋白質科学会年会プログラム・要旨集, 23rd (CD-ROM), 2023
X-ray crystal structure analysis of SARS-CoV-2 spike protein and neutralizing antibody NT-193 complex

喜多俊介, 小野寺大志, 安達悠, 森山彩野, 野村尚生, 田所高志, 安楽佑樹, 湯本航平, 田聡, 福原秀雄 …

量子ビームサイエンスフェスタ(Web), 2021, 2022
新型コロナウイルスspike蛋白質と中和抗体NT-193複合体のX線結晶構造解析

喜多俊介, 小野寺大志, 安達悠, 森山彩野, 野村尚生, 田所高志, 安楽佑樹, 湯本航平, 田聡, 福原秀雄 …

日本結晶学会年会講演要旨集, 2021, 2021
タンパク質の運命を制御する生体システムと疾病のフロンティア小胞体ストレス応答性酸化還元調節酵素を標的とした創薬スクリーニング

野村尚生, 松丸尊紀, 春山知樹, 前田直良, 奥村正樹, 金村進吾, 稲葉謙次, 田村保明, 前仲勝実

日本生化学会大会プログラム・講演要旨集, 92回 [2S03m-05], Sep, 2019
アカデミア創薬における小胞体ストレス応答性酵素を標的とした抗癌剤スクリーニング

野村尚生, 松丸尊紀, 春山知樹, 前田直良, 奥村正樹, 金村進吾, 稻葉謙次, 田村保明, 前仲勝実

日本分子生物学会年会プログラム・要旨集(Web), 42nd, 2019
ヒト単純ヘルペスウイルス由来糖ペプチドと免疫受容体PILRα相互作用解析

野村尚生, 柿田浩輔, 古川敦, 穴田仁洋, 橋下俊一, 松永茂樹, 齊藤貴士, 前仲勝実, 前仲勝実

Abstracts. Annual Meeting of the NMR Society of Japan, 57th 198‐199, Sep 3, 2018
HSV-1感染における糖ペプチドと免疫受容体PILRα相互作用解析

野村尚生, 柿田浩輔, 古川敦, 穴田仁洋, 橋下俊一, 松永茂樹, 齊藤貴士, 前仲勝実

日本薬学会年会要旨集, 138年会(2) 245-245, Mar, 2018
HSV‐1感染における糖ペプチドと免疫受容体PILRα相互作用解析

野村尚生, 柿田浩輔, 古川敦, 穴田仁洋, 橋下俊一, 松永茂樹, 齊藤貴士, 前仲勝実, 前仲勝実

日本薬学会年会要旨集(CD-ROM), 138th(2) ROMBUNNO.28X‐am02-245, Mar, 2018
タンパク質の構造異常を検出できるファージの開発と神経変性疾患の病理解明への応用

古川良明, 徳田栄一, 長澤健一, 野村尚生, 山中宏二, 三澤日出巳, 大原慎司

生体分子科学討論会講演要旨集, 44th 20‐21, Jun 23, 2017
抗がん剤を目指した若手研究者連携による創薬スクリーニング

野村尚生, 松丸尊紀, 奥村正樹, 稲葉謙次, 田村保明, 前仲勝実

日本薬学会年会要旨集(CD-ROM), 137th ROMBUNNO.S13‐4, 2017
EVOLUTION OF THE TETRAMERIZATION DOMAIN IN TUMOR SUPPRESSOR PROTEIN P53

N. Nakagawa, J. Wada, R. Kamada, T. Nomura, T. Imagawa, K. Sakaguchi

JOURNAL OF PEPTIDE SCIENCE, 22 S22-S22, Sep, 2016
神経変性疾患の治療法開発を目指したミスフォールドタンパク質認識ペプチドの作製

古川良明, 長澤健一, 徳田栄一, 野村尚生

日本蛋白質科学会年会プログラム・要旨集, 16th 149, May 19, 2016
小胞体ストレスタンパク質を標的とした抗癌剤スクリーニング

野村尚生, 鈴木華央, 松丸尊紀, 奥村正樹, 稲葉謙次, 田村保明, 前仲勝実

日本薬学会年会要旨集(CD-ROM), 136th(2) ROMBUNNO.28S‐PM06-66, Mar, 2016
Structural Analysis for the Interaction of sialic T antigen glycopeptide of HSV-1 with Entry Receptor PILR alpha

Takao Nomura, Jiro Sakamoto, Fumina Oosaka, Kosuke Kakita, Atsushi Furukawa, Masahiro Anada, Shunichi Hashimoto, Kimiko Kuroki, Toyoyuki Ose, Hisashi Arase …

PROTEIN SCIENCE, 23 230-230, Jul, 2014
Low Threshold of Destabilization for Loss of Tumor Suppressor Activity of p53 : A Quantitative Analysis of p53 Tetramerization Domain Mutants

KAMADA Rui, NOMURA Takao, CHUMAN Yoshiro, IMAGAWA Toshiaki, ANDERSON Carl W., SAKAGUCHI Kazuyasu

2010 149-149, Mar 1, 2011
p53四量体形成ドメインを介した空間配向制御によるバイオミネラリゼーションの活性増強と構造制御

坂口達也, 鎌田瑠泉, 野村尚生, 中馬吉郎, 今川敏明, 坂口和靖

日本化学会講演予稿集, 90th(3), 2010
p53四量体形成ドメインとバイオミネラリゼーションペプチドの融合による銀粒子の構造制御

坂口達也, 鎌田瑠泉, 野村尚生, 中馬吉郎, 今川敏明, 坂口和靖

日本化学会北海道支部夏季研究発表会講演要旨集, 2010, 2010
Thermal Stability of p53 Tetramerization Domain Peptides Derived from Various Species

NOMURA Takao, KAMADA Rui, CHUMAN Yoshiro, SAKAGUCHI Kazuyasu

2008 35-36, Mar 1, 2009
Structural Photomodulation of Peptides with Azobenzoate Derivative in Peptide Backbone

KAMADA Rui, FUKUDA Kouichiro, MIYAZAKI Hiromitsu, NOMURA Takao, CHUMAN Yoshiro, IMAGAWA Toshiaki, TANINO Keiji, SAKAGUCHI Kazuyasu

2007 447-448, Mar 1, 2008
Correlation between Expression Level in E. coli and Stability of Oligomeric Structure of the p53 Tetramerization Domain

MIYAZAKI Hiromitsu, KAMADA Rui, NOMURA Takao, CHUMAN Yoshiro, IMAGAWA Toshiaki, SAKAGUCHI Kazuyasu

2007 317-318, Mar 1, 2008

Teaching Experience

Research Projects

Elucidation of protein networks for the mechanism of carcinogenesis through the oxidoreductase in the endoplasmic reticulum

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Nomura Takao
Elucidation of oncogenic molecular mechanism mediated by redox regulatory enzyme based on novel inhibitor

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

NOMURA Takao
A mechanism regulating the copper acquisition by intracellular proteins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

FURUKAWA YOSHIAKI, NOMURA Takao

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