KATSUNORI NONOGAKI - My portal

Profile Information

Affiliation: Cyclotron and Radioisotope Center, Tohoku University

Degree: MD, PhD(Mar, 1993, Nagoya University)

J-GLOBAL ID: 201801011145732115
researchmap Member ID: B000346803

Dr. Nonogaki has worked as a Postdoc Research Fellow at the University of California, San Francisco and the Scripps Research Institute, La Jolla. He has studied central serotonin network in the regulation of appetite and energy homeostasis. Lorcaserin (Belviq), a selective 5-HT2C receptor agonist, which is used for the treatment of obesity, is based on the original research works by Dr. Nonogaki et al. Current studies are to determine the network of gut-derived hormones and liver-derived hormones in the regulation of obesity and type 2 diabetes. Dr. Nonogaki also has a novel ultrasound irradiation device for hypertension and diabetes.

Research Interests

Research Areas

Papers

Ingestion of whey protein and β-conglycinin exerts opposite effects on intestinal FGF15 and serotonin secretion in mice

Katsunori Nonogaki, Takao Kaji

Frontiers in Endocrinology, 14 1080790., Jan 27, 2023 Peer-reviewedLead authorCorresponding author
The Regulatory Role of the Central and Peripheral Serotonin Network on Feeding Signals in Metabolic Diseases.

Katsunori Nonogaki

International journal of molecular sciences, 23(3), Jan 29, 2022 Peer-reviewedLead authorCorresponding author
Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and KKAy mice

Katsunori Nonogaki, Takao Kaji

Heliyon, 6(12) e05774-e05774, Dec, 2020 Peer-reviewedLead authorCorresponding author
Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet

Katsunori Nonogaki, Takao Kaji

Scientific Reports, (10) 15784, Sep 25, 2020 Peer-reviewedLead authorCorresponding author
Low-frequency and low-intensity ultrasound increases cardiac parasympathetic neural activity and decreases clinic hypertension in elderly hypertensive subjects with type 2 diabetes

Katsunori Nonogaki, Mari Murakami, Tomoe Yamazaki, Naohiko Nonogaki

IJC Heart and Vasculature, 19 34-36, Jun 1, 2018 Peer-reviewed
Liraglutide, a GLP-1 Receptor Agonist, Which Decreases Hypothalamic 5-HT2A Receptor Expression, Reduces Appetite and Body Weight Independently of Serotonin Synthesis in Mice

Katsunori Nonogaki, Takao Kaji

Journal of Diabetes Research, 2018 6482958, 2018 Peer-reviewed
215

A Tryptophan Hydroxylase Inhibitor Increases Hepatic FGF21 Production and Decreases Hepatic Gluconeogenesis Independently of Insulin in db/db Mice

Nonogaki K, Kaji T, Murakami M

Neuropsychiatry, 8(4) 1476-1481, 2018 Peer-reviewed
313

A Tryptophan Hydroxylase Inhibitor Decreases Hepatic FGF21 Expression and Circulating FGF21 in Mice Fed A High-Fat Diet

Nonogaki K, Kaji T, Murakami M

Neuropsychiatry, 8(1) 372-377, 2018 Peer-reviewed
Low-frequency and low-intensity ultrasound irradiation to the forearm improves an index of arterial stiffness in subjects with type 2 diabetes and hypertension

Katsunori Nonogaki, Mari Murakami, Tomoe Yamazaki, Naohiko Nonogaki

IJC Heart and Vasculature, 16 4-6, Sep 1, 2017 Peer-reviewed
alpha 1-Adrenergic receptor downregulates hepatic FGF21 production and circulating FGF21 levels in mice

Katsunori Nonogaki, Takao Kaji

NEUROSCIENCE LETTERS, 638 35-38, Jan, 2017 Peer-reviewed
Treatment with FGFR2-IIIc monoclonal antibody suppresses weight gain and adiposity in KKA(y) mice

K. Nonogaki, T. Kaji, T. Yamazaki, Mari Murakami

NUTRITION & DIABETES, 6, Nov, 2016 Peer-reviewed
The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice

Katsunori Nonogaki, Takao Kaji

DIABETES RESEARCH AND CLINICAL PRACTICE, 120 186-189, Oct, 2016 Peer-reviewed
Low-frequency and very low-intensity ultrasound decreases blood pressure in hypertensive subjects with type 2 diabetes

Katsunori Nonogaki, Tomoe Yamazaki, Mari Murakami, Noriko Satoh, Miki Hazama, Kouji Takeda, Nobuyuki Tsujita, Shuichi Katoh, Nariki Kubota

INTERNATIONAL JOURNAL OF CARDIOLOGY, 215 147-149, Jul, 2016 Peer-reviewed
Decreased energy intake versus increased lipolysis in the prevention of type 2 diabetes.

Nonogaki K

Integr Obesity Diabetes., 2(5) 1-1, 2016 Peer-reviewed
Pharmacologic stimulation of central GLP-1 receptors has opposite effects on the alterations of plasma FGF21 levels induced by feeding and fasting

Katsunori Nonogaki, Takao Kaji, Tomoe Yamazaki, Mari Murakami

NEUROSCIENCE LETTERS, 612 14-17, Jan, 2016 Peer-reviewed
Gut microbiota-induced 5-HT synthesis and obesity.

Nonogaki K

J. Endocrinology and Diabetes, 1-1, Dec, 2015 Peer-reviewed
Mosapride, a selective serotonin 5-HT4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active GLP-1 levels and glucose tolerance in mice

Katsunori Nonogaki, Takao Kaji

DIABETES RESEARCH AND CLINICAL PRACTICE, 110(3) E18-E21, Dec, 2015 Peer-reviewed
Pharmacological stimulation of serotonin 5-HT1B receptors enhances increases in plasma active glucagon-like peptide-1 levels induced by dipeptidyl peptidase-4 inhibition independently of feeding in mice

K. Nonogaki, T. Kaji

DIABETES & METABOLISM, 41(5) 425-428, Nov, 2015 Peer-reviewed
Ingestion of eicosapentaenoic acid in the early stage of social isolation reduces a fibroblast growth factor 21 resistant state independently of body weight in KKA(y) mice

Katsunori Nonogaki, Tomoe Yamazaki, Mari Murakami, Takao Kaji

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464(2) 674-677, Aug, 2015 Peer-reviewed
Neural Control of Energy Balance: Translating Circuits to Therapies

Laurent Gautron, Joel K. Elmquist, Kevin W. Williams

CELL, 161(1) 133-145, Mar, 2015 Peer-reviewed

Misc.

Comment on: Satoh-Asahara et al. Highly Purified Eicosapentaenoic Acid Increases Interleukin-10 Levels of Peripheral Blood Monocytes in Obese Patients With Dyslipidemia. Diabetes Care 2012;35:2631-2639

Katsunori Nonogaki

DIABETES CARE, 36(7) E109-E109, Jul, 2013
Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.

Nonogaki K, Nozue K, Takahashi Y, Yamashita N, Hiraoka S, Kumano H, Kuboki T, Oka Y

Int J Neuropsychopharmacol, 1-7, 2006
Role of 5-HT2C receptors in regulation of energy metabolism and the anorexic effects of SSRI and SNRI

K Nonogaki

JOURNAL OF PSYCHOSOMATIC RESEARCH, 58(6) S22-S22, Jun, 2005
Isolation stress can modulate energy homeostasis associated with alterations of plasma insulin and ghrelin levels in mice

Y Takahashi, K Nonogaki, H Kumano, T Kuboki

JOURNAL OF PSYCHOSOMATIC RESEARCH, 58(6) S22-S22, Jun, 2005
Dissociation of 5-HT2C receptor signaling and central melanocortin pathways in regulation of appetite

K Nonogaki, Y Mooka

DIABETES, 54 A384-A384, 2005
Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT2c receptor mutant mice

K Nonogaki, KR Feingold, LH Tecott

DIABETES, 51 A419-A419, Jun, 2002
Serotonin 5-HT2c receptor mutant mice develop obesity, a prediabetic state and moderate leptin insensitivity

K Nonogaki, AM Strack, MF Dallman, LH Tecott

DIABETES, 47 A320-A320, May, 1998
Effects of adrenergic blockers on 2-deoxy-D-glucose induced hyperglycemia in fed rats.

A. Iguchi, H. Matsunaga, M. Gotoh, H. Miura, K. Uemura, T. Tamagawa, K. Nonogaki, N. Sakamoto

Exp. Clin. Endocrinol., 9 7-12, 1990 Peer-reviewed

Professional Memberships

Research Projects

食事性タンパク質による摂食シグナルと代謝制御機構

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

野々垣勝則
Determining GLP-1 responsive genes involved in the regulation of appetite and energy metabolism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

NONOGAKI Katsunori
Age-associated changes in metabolic responses and the regulatory system.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2009

NONOGAKI Katunori
Role of brain serotonin systems and ghrelin in the regulation of feeding behavior

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

NONOGAKI Katsunori, EZAKI Osamu

Industrial Property Rights

特許6373647 超音波照射装置及び診断システム

野々垣勝則
特許第6004231号超音波照射パッド、固定パッド、及び、超音波照射装置

野々垣勝則
特許US9649511 A Method of irradiating supersonic waves

野々垣勝則
特開2013-233416 超音波照射装置及び診断システム

野々垣勝則
特開2013-059332 マウスの生育過程において社会的隔離に対する肥満又は糖尿病発症の感受性を解析する方法

野々垣勝則
WO2012-132001 超音波照射装置

野々垣勝則
特開2011-212276 超音波照射装置

野々垣勝則
特開2011-092285 超音波発生装置

野々垣勝則, 岡山克彦
特開2008-178363 レプチンシグナル伝達障害モデル動物

野々垣勝則
特開2008-156241 体重減少薬

野々垣勝則
特開2007-282582 被検物質の食欲抑制効果をスクリーニングする方法

野々垣勝則
特許第4176438号薬品決定支援システム、および薬品決定支援プログラム

野々垣勝則
特許第3848818号生体の代謝状態を解析する装置及び記録媒介

野々垣勝則

Academic Activities

Associate Editor

Review, evaluation, Peer review

Frontiers in Psychology, Jun, 2023 - Present
Topic Editor, Insights in Obesity 2023

Planning, management, etc., Planning/Implementing academic research, Peer review

Frontiers in Endocrinology, May, 2023 - Present
Topical Advisory Panel for “Molecular Endocrinology and Metabolism”

Planning, management, etc., Planning/Implementing academic research, Peer review

International Journal of Molecular Sciences, Apr, 2023 - Present
30

Guest Editor, Special Issue "New sights into the Serotonin system, Obesity and Diabetes", International Journal of Molecular Sciences.

Planning, management, etc., Supervision (editorial), Peer review

International Journal of Molecular Sciences, Apr, 2023 - Present
Associate Editor, Obesity

Review, evaluation, Planning/Implementing academic research, Peer review

Frontiers in Endocrinology, Oct, 2022 - Present
Obesity section, Frontiers in Endocrinology

Planning, management, etc., Supervision (editorial), Peer review

Katsunori Nonogaki, Chen Liu, Gregory R. Steinberg, Aug, 2022 - Present
Guest Editor, Special Issue "State-of-the-Art Molecular Neurobiology in Japan"

Planning, management, etc., Supervision (editorial), Peer review

2022 - Present
98

Serotonin Network and Energy Metabolism as a Special Issue in IJMS

Planning, management, etc., Supervision (editorial), Planning/Implementing academic research, Peer review

IJMS

Media Coverage

Ingestion of whey protein and bconglycinin exerts opposite effects on intestinal FGF15 and serotonin secretion in mice

Jun 5, 2023 Internet
食事性蛋白質による胆汁酸シグナルの変化を発見 -腸細胞のFGF15/19産生に着目した食事のイノベーションへ-

東北大学未来科学技術共同研究センタープレスリリース, Feb 13, 2023 Internet
乳清タンパク質ホエイプロテインの新たな効能を発見 - セロトニンとFGF21の分泌抑制により、2型糖尿病の発症を抑制 -

東北大学プレスリリース・研究成果, 日本経済新聞等複数、インターネットメデイア, Oct 7, 2020