Takayuki Nonoyama
(野々山 貴行)Profile Information
- Affiliation
- Associate Professor, Faculty of Advanced Life Science, Hokkaido University
- Degree
-
Doctor of Engineering(Mar, 2013, Nagoya Institute of Technology)
- Researcher number
- 50709251
- ORCID ID
- https://orcid.org/0000-0001-8554-0636
- J-GLOBAL ID
- 201501016090187332
- researchmap Member ID
- B000246156
- External link
Cartilage tissues are a single-use tissue like an eraser that can not be expected to cure naturally if it is degraded or damaged due to injury, disease, aging, etc. Although the current radical treatment is artificial joint replacement, which replaces hard materials, not only normal tissues have to be resected, but also there are clinical problems such as loosening in long-term use. Therefore, there is a strong demand for developments of next-generation artificial cartilage and ultimate tissue reconstruction. We have developed a robust gel that satisfies the physical properties required for artificial cartilage, and are further developing technology to firmly fix it in proper place of defect for a long time. Focusing on the fact that natural cartilage tissue is in continuous contact with bone tissue, when the inorganic main component of bone is combined with gel, bone regeneration can penetrate inside the gel and achieve non-toxic and strong adhesion. We are also creating high-strength composite materials by combining bioceramics and hydrogel.
General polymer materials behave as a hard glassy state below glass-transition temperature (Tg), and change to a soft rubbery state above Tg. We are creating temperature-responsive active materials that are more than 1000 times harder at high temperatures, which is the reverse thermal behavior of general polymers. This material is extremely easy to make, using very inexpensive and non-toxic chemicals, and can be hardened repeatedly. This material is intended to be used as a smart protector responsive to heat and a heat absorbing material that absorbs heat from sunlight and reduces the temperature rise in the room.
Research Interests
12Research Areas
5Research History
6-
Jun, 2021 - Present
Education
1Major Awards
17Papers
75-
Soft Matter, 19(40) 7724-7730, Sep, 2023 Peer-reviewed
-
Scientific Reports, 13(1), Feb 14, 2023 Peer-reviewed
-
Journal of Vascular and Interventional Radiology, Jan, 2023 Peer-reviewed
-
Cancers, 14(23) 5890-5890, Nov 29, 2022 Peer-reviewed
-
Advanced Materials, 35(1) 2208902-2208902, Nov 9, 2022 Peer-reviewedCorresponding author
-
Nature Communications, 13(1), Oct 20, 2022 Peer-reviewed
-
Proceedings of the National Academy of Sciences of the United States of America, 119(42) e2206685119, Oct 18, 2022 Peer-reviewed
-
Journal of the Ceramic Society of Japan, 130(10) 817-824, Oct 1, 2022 Peer-reviewedInvitedLead authorCorresponding author
-
Science translational medicine, 14(647) eabj5557, Jun, 2022 Peer-reviewed
-
Biomaterials science, 10(9) 2182-2187, May 4, 2022 Peer-reviewed
-
日本病理学会会誌, 111(1) 263-263, Mar, 2022
-
日本病理学会会誌, 111(1) 263-263, Mar, 2022
-
EBioMedicine, 76 103845-103845, Jan 24, 2022 Peer-reviewed
-
Journal of biomedical materials research. Part A, 110(4) 747-760, Oct 28, 2021 Peer-reviewed
-
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN, 129(9) 584-589, Sep, 2021 Peer-reviewedLead authorCorresponding author
-
日本整形外科学会雑誌, 95(8) S1561-S1561, Aug, 2021
-
The American Journal of Sports Medicine, 036354652110141-036354652110141, Jun 1, 2021 Peer-reviewed
-
Annual review of chemical and biomolecular engineering, Mar 26, 2021 Peer-reviewedLead author
-
The Journal of bone and joint surgery. American volume, 103(8) e31, Jan 21, 2021 Peer-reviewed
-
Advanced healthcare materials, 10(3) e2001731, Nov 16, 2020 Peer-reviewedLead authorCorresponding author
Misc.
17-
Bulletin of the Ceramics Society of Japan, 55(3) 166-170, Mar, 2020 Lead author
-
日本軟骨代謝学会プログラム・抄録集, 33rd, 2020
-
整形外科バイオマテリアル研究会プログラム・抄録集, 38th 38, Nov, 2018
-
機能材料, 38(5) 51-59, May, 2018
-
高分子学会予稿集(CD-ROM), 67(2), 2018
-
日本セラミックス協会秋季シンポジウム講演予稿集(CD-ROM), 31st, 2018
-
日本整形外科学会雑誌, 91(8) S1468-S1468, Aug, 2017
-
Fine ceramics report, 35(4) 148-152, 2017
-
高分子学会予稿集(CD-ROM), 66(2), 2017
-
日本バイオマテリアル学会シンポジウム予稿集, 2016 230-230, Nov 21, 2016
-
日本整形外科学会雑誌, 90(8) S1726-S1726, Aug, 2016
-
高分子学会北海道支部研究発表会講演要旨集, 49th 6, 2015
-
高分子学会予稿集(CD-ROM), 63(1) ROMBUNNO.2PD046, May 9, 2014
-
日本セラミックス協会年会講演予稿集(CD-ROM), 2014 ROMBUNNO.1P141, Mar 7, 2014
-
日本セラミックス協会年会講演予稿集(CD-ROM), 2014 ROMBUNNO.1J24, Mar 7, 2014
-
化学系学協会北海道支部冬季研究発表会講演要旨集(CD-ROM), 2014 ROMBUNNO.P38, Jan 28, 2014
-
化学, 66(8) 66-67, Aug 1, 2011
Books and Other Publications
1-
技術情報協会, Jul, 2014 (ISBN: 4861045363)
Presentations
140-
高分子ゲル研究討論会講演要旨集, Jan 9, 2019
-
高分子ゲル研究討論会講演要旨集, Jan 9, 2019
-
整形外科バイオマテリアル研究会プログラム・抄録集, Nov, 2018
-
高分子学会予稿集(CD-ROM), Aug 29, 2018
-
高分子学会予稿集(CD-ROM), Aug 29, 2018
-
高分子学会予稿集(CD-ROM), Aug 29, 2018
-
高分子学会予稿集(CD-ROM), Aug 29, 2018
-
高分子学会予稿集(CD-ROM), Aug 29, 2018
-
高分子学会予稿集(CD-ROM), Aug 29, 2018
-
高分子学会予稿集(CD-ROM), Aug 29, 2018
-
高分子学会予稿集(CD-ROM), Aug 29, 2018
-
高分子学会予稿集(CD-ROM), Aug 29, 2018
-
高分子学会予稿集(CD-ROM), May 8, 2018
-
高分子学会予稿集(CD-ROM), May 8, 2018
-
日本セラミックス協会年会講演予稿集(CD-ROM), Mar 1, 2018
-
日本セラミックス協会年会講演予稿集(CD-ROM), Mar 1, 2018
-
高分子学会北海道支部研究発表会講演要旨集, Jan 15, 2018
-
高分子学会北海道支部研究発表会講演要旨集, Jan 15, 2018
-
高分子学会北海道支部研究発表会講演要旨集, Jan 15, 2018
-
高分子学会北海道支部研究発表会講演要旨集, Jan 15, 2018
Teaching Experience
2Professional Memberships
3Research Projects
12-
Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (International Leading Research ), Fund for the Promotion of Joint International Research (International Leading Research ), Japan Society for the Promotion of Science, Dec, 2022 - Mar, 2029
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2027
-
2020年度創発的研究支援事業, 国立研究開発法人科学技術振興機構, Apr, 2021 - Mar, 2027
-
Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2026
-
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
-
科学研究費助成事業 基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2024
-
Grant-in-Aid for Scientific Research (S), Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2017 - Mar, 2022
-
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2017 - Feb, 2022
-
Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2020
-
Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2018
-
Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2012 - Mar, 2017
-
科学研究費助成事業 若手研究B, 日本学術振興会, Apr, 2014 - Mar, 2017