2016年11月
MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus
BIOLOGY OPEN
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回数 : 41
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- 巻
- 5
- 号
- 11
- 開始ページ
- 1631
- 終了ページ
- 1641
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1242/bio.018945
- 出版者・発行元
- COMPANY OF BIOLOGISTS LTD
Ocular morphogenesis requires several signalling pathways controlling the expression of transcription factors and cell-cycle regulators. However, despite a well-known mechanism, the dialogue between those signals and factors remains to be unveiled. Here, we identify a requirement for MarvelD3, a tight junction transmembrane protein, in eye morphogenesis in Xenopus. MarvelD3 depletion led to an abnormally pigmented eye or even an eye-less phenotype, which was rescued by ectopic MarvelD3 expression. Altering MarvelD3 expression led to deregulated expression of cell-cycle regulators and transcription factors required for eye development. The eye phenotype was rescued by increased c-Jun terminal Kinase activation. Thus, MarvelD3 links tight junctions and modulation of the JNK pathway to eye morphogenesis.
- リンク情報
- ID情報
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- DOI : 10.1242/bio.018945
- ISSN : 2046-6390
- PubMed ID : 27870636
- Web of Science ID : WOS:000388302100009