2019年
Glutamate as intracellular and extracellular signals in pancreatic islet functions.
Proceedings of the Japan Academy. Series B, Physical and biological sciences
- ,
- ,
- 巻
- 95
- 号
- 6
- 開始ページ
- 246
- 終了ページ
- 260
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2183/pjab.95.017
l-Glutamate is one of the most abundant amino acids in the body and is a constituent of proteins and a substrate in metabolism. It is well known that glutamate serves as a primary excitatory neurotransmitter and a critical neuromodulator in the brain. Recent studies have shown that in addition to its pivotal role in neural functions, glutamate plays many important roles in a variety of cellular functions, including those as intracellular and extracellular signals. In pancreatic islets, glutamate is now known to be required for the normal regulation of insulin secretion, such as incretin-induced insulin secretion. In this review, we primarily discuss the physiological and pathophysiological roles of glutamate as intracellular and extracellular signals in the functions of pancreatic islets.
- リンク情報
- ID情報
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- DOI : 10.2183/pjab.95.017
- PubMed ID : 31189778
- PubMed Central 記事ID : PMC6751295