論文

査読有り 筆頭著者 国際誌
2018年10月

Social reward monitoring and valuation in the macaque brain.

Nature Neuroscience
  • Atsushi Noritake
  • ,
  • Taihei Ninomiya
  • ,
  • Masaki Isoda

21
10
開始ページ
1452
終了ページ
1462
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41593-018-0229-7

Behaviors are influenced by rewards to both oneself and others, but the neurons and neural connections that monitor and evaluate rewards in social contexts are unknown. To address this issue, we devised a social Pavlovian conditioning procedure for pairs of monkeys. Despite being constant in amount and probability, the subjective value of forthcoming self-rewards, as indexed by licking and choice behaviors, decreased as partner-reward probability increased. This value modulation was absent when the conspecific partner was replaced by a physical object. Medial prefrontal cortex neurons selectively monitored self-reward and partner-reward information, whereas midbrain dopaminergic neurons integrated this information into a subjective value. Recordings of local field potentials revealed that responses to reward-predictive stimuli in medial prefrontal cortex started before those in dopaminergic midbrain nuclei and that neural information flowed predominantly in a medial prefrontal cortex-to-midbrain direction. These findings delineate a dedicated pathway for subjective reward evaluation in social environments.

リンク情報
DOI
https://doi.org/10.1038/s41593-018-0229-7
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30224807
ID情報
  • DOI : 10.1038/s41593-018-0229-7
  • ISSN : 1097-6256
  • PubMed ID : 30224807

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