2017年3月
Hotspots of MLV integration in the hematopoietic tumor genome
ONCOGENE
- ,
- ,
- 巻
- 36
- 号
- 9
- 開始ページ
- 1169
- 終了ページ
- 1175
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/onc.2016.285
- 出版者・発行元
- NATURE PUBLISHING GROUP
Extensive research has been performed regarding the integration sites of murine leukemia retrovirus (MLV) for the identification of proto-oncogenes. To date, the overlap of mutations within specific oligonucleotides across different tumor genomes has been regarded as a rare event; however, a recent study of MLV integration into the oncogene Zfp521 suggested the existence of a hotspot oligonucleotide for MLV integration. In the current review, we discuss the hotspots of MLV integration into several genes: c-Myc, Stat5a and N-myc, as well as ZFP521, as examined in tumor genomes. From this, MLV integration convergence within specific oligonucleotides is not necessarily a rare event. This short review aims to promote re-consideration of MLV integration within the tumor genome, which involves both well-known and potentially newly identified and novel mechanisms and specifications.
- リンク情報
- ID情報
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- DOI : 10.1038/onc.2016.285
- ISSN : 0950-9232
- eISSN : 1476-5594
- Web of Science ID : WOS:000395861300001