論文

査読有り 国際誌
2020年8月7日

Binding of Dopamine D1 Receptor and Noradrenaline Transporter in Individuals with Autism Spectrum Disorder: A PET Study.

Cerebral cortex (New York, N.Y. : 1991)
  • Manabu Kubota
  • ,
  • Junya Fujino
  • ,
  • Shisei Tei
  • ,
  • Keisuke Takahata
  • ,
  • Kiwamu Matsuoka
  • ,
  • Kenji Tagai
  • ,
  • Yasunori Sano
  • ,
  • Yasuharu Yamamoto
  • ,
  • Hitoshi Shimada
  • ,
  • Yuhei Takado
  • ,
  • Chie Seki
  • ,
  • Takashi Itahashi
  • ,
  • Yuta Y Aoki
  • ,
  • Haruhisa Ohta
  • ,
  • Ryu-Ichiro Hashimoto
  • ,
  • Ming-Rong Zhang
  • ,
  • Tetsuya Suhara
  • ,
  • Motoaki Nakamura
  • ,
  • Hidehiko Takahashi
  • ,
  • Nobumasa Kato
  • ,
  • Makoto Higuchi

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/cercor/bhaa211

Although previous studies have suggested the involvement of dopamine (DA) and noradrenaline (NA) neurotransmissions in the autism spectrum disorder (ASD) pathophysiology, few studies have examined these neurotransmissions in individuals with ASD in vivo. Here, we investigated DA D1 receptor (D1R) and noradrenaline transporter (NAT) binding in adults with ASD (n = 18) and neurotypical controls (n = 20) by utilizing two different PET radioligands, [11C]SCH23390 and (S,S)-[18F]FMeNER-D2, respectively. We found no significant group differences in DA D1R (striatum, anterior cingulate cortex, and temporal cortex) or NAT (thalamus and pons) binding. However, in the ASD group, there were significant negative correlations between DA D1R binding (striatum, anterior cingulate cortex and temporal cortex) and the "attention to detail" subscale score of the Autism Spectrum Quotient. Further, there was a significant positive correlation between DA D1R binding (temporal cortex) and emotion perception ability assessed by the neurocognitive battery. Associations of NAT binding with empathic abilities and executive function were found in controls, but were absent in the ASD group. Although a lack of significant group differences in binding might be partly due to the heterogeneity of ASD, our results indicate that central DA and NA function might play certain roles in the clinical characteristics of ASD.

リンク情報
DOI
https://doi.org/10.1093/cercor/bhaa211
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32770189

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