論文

査読有り
2017年4月

Monitoring of Human Herpesviruses-6 and-7 DNA in Saliva Samples During the Acute and Convalescent Phases of Exanthem Subitum

JOURNAL OF MEDICAL VIROLOGY
  • Yuki Miyazaki
  • ,
  • Hikaru Namba
  • ,
  • Sadayoshi Torigoe
  • ,
  • Masahiro Watanabe
  • ,
  • Nobuko Yamashita
  • ,
  • Hirohito Ogawa
  • ,
  • Tsuneo Morishima
  • ,
  • Masao Yamada

89
4
開始ページ
696
終了ページ
702
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/jmv.24690
出版者・発行元
WILEY-BLACKWELL

The amounts of the DNAs of human herpesviruses-6 (HHV-6) and -7 (HHV-7) in saliva samples were monitored during the acute and convalescent phases of exanthem subitum (ES) to elucidate the kinetics of virus shedding after ES. A total of 247 saliva samples were collected from 17 children (5 males and 12 females: 8-31 months old at onset). The monitoring period ranged from 152 to 721 days after onset, and in 15 children it was longer than 1 year. Among the 17 cases, 16 were attributed to HHV-6B, while a single case was attributed to HHV-7. Detection rates and average amounts of HHV-6 DNA in saliva samples after ES attributed to HHV-6B were low in the acute phase, increased to the maximum in the convalescent phase at 3-7 months, and then decreased. In addition, to investigate the source of infection, saliva samples from the older siblings (age 3-9 years) and parents of ES patients and children with a history of ES were also examined. The detection rate of HHV-6 DNA in saliva samples from 3- to 9-year-old children was significantly higher than the rate in adult saliva samples. Taken together, these findings suggest that the saliva of children in the convalescent phase of ES might be a more likely source of HHV-6 infection than that of adults. (C) 2016 Wiley Periodicals, Inc.

リンク情報
DOI
https://doi.org/10.1002/jmv.24690
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27648817
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000393895000017&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/jmv.24690
  • ISSN : 0146-6615
  • eISSN : 1096-9071
  • PubMed ID : 27648817
  • Web of Science ID : WOS:000393895000017

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