2017年4月
Monitoring of Human Herpesviruses-6 and-7 DNA in Saliva Samples During the Acute and Convalescent Phases of Exanthem Subitum
JOURNAL OF MEDICAL VIROLOGY
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 89
- 号
- 4
- 開始ページ
- 696
- 終了ページ
- 702
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/jmv.24690
- 出版者・発行元
- WILEY-BLACKWELL
The amounts of the DNAs of human herpesviruses-6 (HHV-6) and -7 (HHV-7) in saliva samples were monitored during the acute and convalescent phases of exanthem subitum (ES) to elucidate the kinetics of virus shedding after ES. A total of 247 saliva samples were collected from 17 children (5 males and 12 females: 8-31 months old at onset). The monitoring period ranged from 152 to 721 days after onset, and in 15 children it was longer than 1 year. Among the 17 cases, 16 were attributed to HHV-6B, while a single case was attributed to HHV-7. Detection rates and average amounts of HHV-6 DNA in saliva samples after ES attributed to HHV-6B were low in the acute phase, increased to the maximum in the convalescent phase at 3-7 months, and then decreased. In addition, to investigate the source of infection, saliva samples from the older siblings (age 3-9 years) and parents of ES patients and children with a history of ES were also examined. The detection rate of HHV-6 DNA in saliva samples from 3- to 9-year-old children was significantly higher than the rate in adult saliva samples. Taken together, these findings suggest that the saliva of children in the convalescent phase of ES might be a more likely source of HHV-6 infection than that of adults. (C) 2016 Wiley Periodicals, Inc.
- リンク情報
- ID情報
-
- DOI : 10.1002/jmv.24690
- ISSN : 0146-6615
- eISSN : 1096-9071
- PubMed ID : 27648817
- Web of Science ID : WOS:000393895000017