2010年7月
Increase of tumor necrosis factor-alpha in the blood induces early activation of matrix metalloproteinase-9 in the brain
MICROBIOLOGY AND IMMUNOLOGY
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- 巻
- 54
- 号
- 7
- 開始ページ
- 417
- 終了ページ
- 424
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1348-0421.2010.00226.x
- 出版者・発行元
- WILEY-BLACKWELL
Increases of cytokine in the blood play important roles in the pathogenesis of influenza-associated encephalopathy. TNF-alpha was administered intravenously to wild-type mice, after which blood, CSF and brain tissue were obtained, and changes in BBB permeability, the amounts of MMP-9 and TIMP-1, and the localization of activated MMP were assessed. There was a significant increase in BBB permeability after 6 and 12 hr. MMP-9 was increased after 3 hr in the brain and cerebrospinal fluid, which was earlier than in the serum. TIMP-1 protein in the brain increased significantly after MMP-9 had increased. Activation of MMP-9 was observed in neurons in the cerebral cortex and hippocampus, and in vascular endothelial cells. These findings suggest that an increase in blood TNF-alpha promotes activation of MMP-9 in the brain, and may also induce an increase in permeability of the BBB. Early activation of MMP-9 in the brain may contribute to an early onset of neurological disorders and brain edema prior to multiple organ failure in those inflammatory diseases associated with highly increased concentrations of TNF-alpha in the blood, such as sepsis, burns, trauma and influenza-associated encephalopathy.
- リンク情報
- ID情報
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- DOI : 10.1111/j.1348-0421.2010.00226.x
- ISSN : 0385-5600
- PubMed ID : 20618688
- Web of Science ID : WOS:000279167900006