Naruhiko Sahara

J-GLOBAL         Last updated: Apr 4, 2019 at 10:06
 
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Name
Naruhiko Sahara
Section
Department of Functional Brain Imaging Research
Job title
Team leader

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
Jul 2010
 - 
Jul 2013
Assistant Professor, Department of Neuroscience, University of Florida
 
Mar 2009
 - 
Jul 2010
Associate Consultant & Assistant Professor, Laboratory of Neurodegenerative Disease Modeling, Mayo Clinic
 
Oct 2008
 - 
Mar 2009
Senior Research Associate, Laboratory of Neurodegenerative Disease Modeling, Mayo Clinic
 

Published Papers

 
Shinotoh H, Shimada H, Kokubo Y, Tagai K, Niwa F, Kitamura S, Endo H, Ono M, Kimura Y, Hirano S, Mimuro M, Ichise M, Sahara N, Zhang MR, Suhara T, Higuchi M
Neurology   92(2) e136-e147   Dec 2018   [Refereed]
Endo H, Shimada H, Sahara N, Ono M, Koga S, Kitamura S, Niwa F, Hirano S, Kimura Y, Ichise M, Shinotoh H, Zhang MR, Kuwabara S, Dickson DW, Toda T, Suhara T, Higuchi M
Movement disorders : official journal of the Movement Disorder Society      Mar 2019   [Refereed]
Ni R, Ji B, Ono M, Sahara N, Zhang MR, Aoki I, Nordberg A, Suhara T, Higuchi M
Journal of nuclear medicine : official publication, Society of Nuclear Medicine   59(6) 960-966   Jun 2018   [Refereed]
Ikeda A, Shimada H, Nishioka K, Takanashi M, Hayashida A, Li Y, Yoshino H, Funayama M, Ueno Y, Hatano T, Sahara N, Suhara T, Higuchi M, Hattori N
Movement disorders : official journal of the Movement Disorder Society      Feb 2019   [Refereed]
Matsumoto G, Matsumoto K, Kimura T, Suhara T, Higuchi M, Sahara N, Mori N
International journal of molecular sciences   19(5)    May 2018   [Refereed]
Goedert M, Yamaguchi Y, Mishra SK, Higuchi M, Sahara N
Frontiers in neurology   9 70   2018   [Refereed]
Sahara N, Maeda J, Ishikawa A, Tokunaga M, Suhara T, Higuchi M
Journal of Alzheimer's disease : JAD   64(s1) S353-S359   2018   [Refereed]
Ishikawa A, Tokunaga M, Maeda J, Minamihisamatsu T, Shimojo M, Takuwa H, Ono M, Ni R, Hirano S, Kuwabara S, Ji B, Zhang MR, Aoki I, Suhara T, Higuchi M, Sahara N
Journal of Alzheimer's disease : JAD   61(3) 1037-1052   2018   [Refereed]
Sahara N, Kimura T
Methods in molecular biology (Clifton, N.J.)   1779 435-445   2018   [Refereed]
Sahara N
Nihon yakurigaku zasshi. Folia pharmacologica Japonica   152(1) 4-9   2018   [Refereed]
Koga S, Ono M, Sahara N, Higuchi M, Dickson DW
Movement disorders : official journal of the Movement Disorder Society   32(6) 884-892   Jun 2017   [Refereed]
Sahara N, Shimojo M, Ono M, Takuwa H, Febo M, Higuchi M, Suhara T
Frontiers in neurology   8 663   2017   [Refereed]
Ono M, Sahara N, Kumata K, Ji B, Ni R, Koga S, Dickson DW, Trojanowski JQ, Lee VM, Yoshida M, Hozumi I, Yoshiyama Y, van Swieten JC, Nordberg A, Suhara T, Zhang MR, Higuchi M
Brain : a journal of neurology   140(3) 764-780   Mar 2017   [Refereed]
Ishigaki S, Fujioka Y, Okada Y, Riku Y, Udagawa T, Honda D, Yokoi S, Endo K, Ikenaka K, Takagi S, Iguchi Y, Sahara N, Takashima A, Okano H, Yoshida M, Warita H, Aoki M, Watanabe H, Okado H, Katsuno M, Sobue G
Cell reports   18(5) 1118-1131   Jan 2017   [Refereed]
Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, Suhara T, Higuchi M, Inoue H
Scientific reports   6 34904   Oct 2016   [Refereed]
Kimura Y, Ichise M, Ito H, Shimada H, Ikoma Y, Seki C, Takano H, Kitamura S, Shinotoh H, Kawamura K, Zhang MR, Sahara N, Suhara T, Higuchi M
Journal of nuclear medicine : official publication, Society of Nuclear Medicine   56(9) 1359-1365   Sep 2015   [Refereed]
Shimojo M, Higuchi M, Suhara T, Sahara N
Frontiers in neuroscience   9 482   2015   [Refereed]
Ward SM, Himmelstein DS, Ren Y, Fu Y, Yu XW, Roberts K, Binder LI, Sahara N
Neurobiology of disease   67 37-48   Jul 2014   [Refereed]
Sahara N, Perez PD, Lin WL, Dickson DW, Ren Y, Zeng H, Lewis J, Febo M
Neurobiology of aging   35(6) 1364-1374   Jun 2014   [Refereed]
Bailey RM, Howard J, Knight J, Sahara N, Dickson DW, Lewis J
Molecular neurodegeneration   9 8   Jan 2014   [Refereed]
Sahara N, Avila J
Frontiers in neurology   5 1   Jan 2014   [Refereed]
Ren Y, Lin WL, Sanchez L, Ceballos C, Polydoro M, Spires-Jones TL, Hyman BT, Dickson DW, Sahara N
Journal of Alzheimer's disease : JAD   38(3) 589-600   2014   [Refereed]
Sahara N, Ren Y, Ward S, Binder LI, Suhara T, Higuchi M
Journal of Alzheimer's disease : JAD   40 Suppl 1 S91-6   2014   [Refereed]
Sahara N, Murayama M, Higuchi M, Suhara T, Takashima A
Frontiers in neurology   5 26   2014   [Refereed]
Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M
Neuron   79(6) 1094-1108   Sep 2013   [Refereed]
Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, Petrucelli L, Sahara N, Dickson DW, Giasson B, Lewis J
Acta neuropathologica   126(1) 39-50   Jul 2013   [Refereed]
Perez PD, Hall G, Kimura T, Ren Y, Bailey RM, Lewis J, Febo M, Sahara N
Molecular neurodegeneration   8 9   Feb 2013   [Refereed]
Sahara N, DeTure M, Ren Y, Ebrahim AS, Kang D, Knight J, Volbracht C, Pedersen JT, Dickson DW, Yen SH, Lewis J
Journal of Alzheimer's disease : JAD   33(1) 249-263   2013   [Refereed]
Ren Y, Sahara N
Frontiers in neurology   4 102   2013   [Refereed]
Yoshiike Y, Yamashita S, Mizoroki T, Maeda S, Murayama M, Kimura T, Sahara N, Soeda Y, Takashima A
Aging cell   11(1) 51-62   Feb 2012   [Refereed]
de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT
Neuron   73(4) 685-697   Feb 2012   [Refereed]
Lin WL, Dickson DW, Sahara N
Journal of neuropathology and experimental neurology   70(9) 779-787   Sep 2011   [Refereed]
Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N
Neurobiology of disease   42(3) 404-414   Jun 2011   [Refereed]
Kimura T, Fukuda T, Sahara N, Yamashita S, Murayama M, Mizoroki T, Yoshiike Y, Lee B, Sotiropoulos I, Maeda S, Takashima A
The Journal of biological chemistry   285(49) 38692-38699   Dec 2010   [Refereed]
Motoi Y, Sahara N, Kambe T, Hattori N
Biomolecular concepts   1(2) 131-145   Aug 2010   [Refereed]
Hori T, Nguyen JH, Zhao X, Ogura Y, Hata T, Yagi S, Chen F, Baine AM, Ohashi N, Eckman CB, Herdt AR, Egawa H, Takada Y, Oike F, Sakamoto S, Kasahara M, Ogawa K, Hata K, Iida T, Yonekawa Y, Sibulesky L, Kuribayashi K, Kato T, Saito K, Wang L, Torii M, Sahara N, Kamo N, Sahara T, Yasutomi M, Uemoto S
World journal of gastroenterology   16(25) 3120-3132   Jul 2010   [Refereed]
Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I
Circulation research   106(11) 1692-1702   Jun 2010   [Refereed]
Sahara N, Maeda S, Takashima A.
Current Alzheimer Research   5(6) 591-598   Dec 2008   [Refereed][Invited]
Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A
The Journal of biological chemistry   283(24) 16488-16496   Jun 2008   [Refereed]
Sahara N, Murayama M, Lee B, Park JM, Lagalwar S, Binder LI, Takashima A
The European journal of neuroscience   27(11) 2897-2906   Jun 2008   [Refereed]
Kimura T, Yamashita S, Nakao S, Park JM, Murayama M, Mizoroki T, Yoshiike Y, Sahara N, Takashima A
PloS one   3(10) e3540   2008   [Refereed]
Kimura T, Yamashita S, Fukuda T, Park JM, Murayama M, Mizoroki T, Yoshiike Y, Sahara N, Takashima A
The EMBO journal   26(24) 5143-5152   Dec 2007   [Refereed]
Sahara N, Maeda S, Yoshiike Y, Mizoroki T, Yamashita S, Murayama M, Park JM, Saito Y, Murayama S, Takashima A
Journal of neuroscience research   85(14) 3098-3108   Nov 2007   [Refereed]
Aluminum induces tau aggregation in vitro but not in vivo.
Mizoroki T, Meshitsuka S, Maeda S, Murayama M, Sahara N, Takashima A
Journal of Alzheimer's disease : JAD   11(4) 419-427   Jul 2007   [Refereed]
Ueno H, Murayama O, Maeda S, Sahara N, Park JM, Murayama M, Sanda A, Iwahashi K, Matsuda M, Takashima A
Biochemical and biophysical research communications   358(2) 602-607   Jun 2007   [Refereed]
Sahara N, Maeda S, Murayama M, Suzuki T, Dohmae N, Yen SH, Takashima A
The European journal of neuroscience   25(10) 3020-3029   May 2007   [Refereed]
Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A
Neuroscience research   57(3) 446-453   Mar 2007   [Refereed]
Maeda S, Sahara N, Saito Y, Murayama M, Yoshiike Y, Kim H, Miyasaka T, Murayama S, Ikai A, Takashima A
Biochemistry   46(12) 3856-3861   Mar 2007   [Refereed]
Tatebayashi Y, Planel E, Chui DH, Sato S, Miyasaka T, Sahara N, Murayama M, Kikuchi N, Yoshioka K, Rivka R, Takashima A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   20(6) 762-764   Apr 2006   [Refereed]
Maeda S, Sahara N, Saito Y, Murayama S, Ikai A, Takashima A
Neuroscience research   54(3) 197-201   Mar 2006   [Refereed]
Sahara N, Murayama M, Mizoroki T, Urushitani M, Imai Y, Takahashi R, Murata S, Tanaka K, Takashima A
Journal of neurochemistry   94(5) 1254-1263   Sep 2005   [Refereed]
Ko LW, DeTure M, Sahara N, Chihab R, Vega IE, Yen SH
Biochimica et biophysica acta   1739(2-3) 125-139   Jan 2005   [Refereed]
Assembly of filamentous tau aggregates in human neuronal cells.
Ko LW, Rush T, Sahara N, Kersh JS, Easson C, Deture M, Lin WL, Connor YD, Yen SH
Journal of Alzheimer's disease : JAD   6(6) 605-22; discussion 673   Dec 2004   [Refereed]
Sahara N, Vega IE, Ishizawa T, Lewis J, McGowan E, Hutton M, Dickson D, Yen SH
Journal of neurochemistry   90(4) 829-838   Aug 2004   [Refereed]
Grover A, England E, Baker M, Sahara N, Adamson J, Granger B, Houlden H, Passant U, Yen SH, DeTure M, Hutton M
Experimental neurology   184(1) 131-140   Nov 2003   [Refereed]
Hogg M, Grujic ZM, Baker M, Demirci S, Guillozet AL, Sweet AP, Herzog LL, Weintraub S, Mesulam MM, LaPointe NE, Gamblin TC, Berry RW, Binder LI, de Silva R, Lees A, Espinoza M, Davies P, Grover A, Sahara N, Ishizawa T, Dickson D, Yen SH, Hutton M, Bigio EH
Acta neuropathologica   106(4) 323-336   Oct 2003   [Refereed]
Ishizawa T, Sahara N, Ishiguro K, Kersh J, McGowan E, Lewis J, Hutton M, Dickson DW, Yen SH
The American journal of pathology   163(3) 1057-1067   Sep 2003   [Refereed]
Hippocampal sclerosis dementia with tauopathy.
Beach TG, Sue L, Scott S, Layne K, Newell A, Walker D, Baker M, Sahara N, Yen SH, Hutton M, Caselli R, Adler C, Connor D, Sabbagh M
Brain pathology (Zurich, Switzerland)   13(3) 263-278   Jul 2003   [Refereed]
Sahara N, Lewis J, DeTure M, McGowan E, Dickson DW, Hutton M, Yen SH
Journal of neurochemistry   83(6) 1498-1508   Dec 2002   [Refereed]
Cellular models for tau filament assembly.
Ko LW, DeTure M, Sahara N, Chihab R, Yen SH
Journal of molecular neuroscience : MN   19(3) 311-316   Dec 2002   [Refereed]
Yuasa S, Nakajima M, Aizawa H, Sahara N, Koizumi K, Sakai T, Usami M, Kobayashi S, Kuroyanagi H, Mori H, Koseki H, Shirasawa T
Journal of neuroscience research   70(3) 501-513   Nov 2002   [Refereed]
Ishii K, Klunk WE, Arawaka S, Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew JW, Mori H
Neuroscience letters   333(1) 5-8   Nov 2002   [Refereed]
Argyrophilic grain disease is a sporadic 4-repeat tauopathy.
Togo T, Sahara N, Yen SH, Cookson N, Ishizawa T, Hutton M, de Silva R, Lees A, Dickson DW
Journal of neuropathology and experimental neurology   61(6) 547-556   Jun 2002   [Refereed]
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E
Science (New York, N.Y.)   293(5534) 1487-1491   Aug 2001   [Refereed]
Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease.
Tamaoka A, Miyatake F, Matsuno S, Ishii K, Nagase S, Sahara N, Ono S, Mori H, Wakabayashi K, Tsuji S, Takahashi H, Shoji S
Neurology   54(12) 2319-2321   Jun 2000   [Refereed]
Sahara N, Tomiyama T, Mori H
Journal of neuroscience research   60(3) 380-387   May 2000   [Refereed]
The tau mutation (val337met) disrupts cytoskeletal networks of microtubules.
Arawaka S, Usami M, Sahara N, Schellenberg GD, Lee G, Mori H
Neuroreport   10(5) 993-997   Apr 1999   [Refereed]
Arai T, Ikeda K, Akiyama H, Haga C, Usami M, Sahara N, Iritani S, Mori H
Acta neuropathologica   97(1) 82-84   Jan 1999   [Refereed]
Tamaoka A, Fraser PE, Ishii K, Sahara N, Ozawa K, Ikeda M, Saunders AM, Komatsuzaki Y, Sherrington R, Levesque G, Yu G, Rogaeva E, Shoji S, Nee LE, Pollen DA, Hendriks L, Martin JJ, Van Broeckhoven C, Roses AD, Farrer LA, St George-Hyslop PH, Mori H
Brain research. Molecular brain research   56(1-2) 178-185   May 1998   [Refereed]
Okochi M, Sahara N, Kametani F, Usami M, Arai T, Tanaka K, Ishii K, Yamamoto A, Mori H
Neurobiology of aging   19(1 Suppl) S3-10   Jan 1998   [Refereed]
Okochi M, Ishii K, Usami M, Sahara N, Kametani F, Tanaka K, Fraser PE, Ikeda M, Saunders AM, Hendriks L, Shoji SI, Nee LE, Martin JJ, Van Broeckhoven C, St George-Hyslop PH, Roses AD, Mori H
FEBS letters   418(1-2) 162-166   Nov 1997   [Refereed]
Ikeda K, Akiyama H, Arai T, Sahara N, Mori H, Usami M, Sakata M, Mizutani T, Wakabayashi K, Takahashi H
Annals of neurology   41(5) 693-695   May 1997   [Refereed]
Takano T, Sahara N, Yamanouchi Y, Mori H
Neuroscience letters   221(2-3) 205-207   Jan 1997   [Refereed]
Yamamoto A, Sahara N, Usami M, Okochi M, Kondo T, Kametani F, Tanaka K, Yahagi Y, Shirasawa T, Itoyama Y, Mori H
Biochemical and biophysical research communications   226(2) 536-541   Sep 1996   [Refereed]
Takano T, Yamanouchi Y, Sahara N, Shirasawa T, Mori H
Neuroscience letters   214(1) 69-71   Aug 1996   [Refereed]
Tokuda T, Kametani F, Tanaka K, Sahara N, Ikeda S, Yanagisawa N
Biochemical and biophysical research communications   223(1) 165-169   Jun 1996   [Refereed]
Sahara N, Yahagi Y, Takagi H, Kondo T, Okochi M, Usami M, Shirasawa T, Mori H
FEBS letters   381(1-2) 7-11   Feb 1996   [Refereed]
Harigaya Y, Shoji M, Kawarabayashi T, Kanai M, Nakamura T, Iizuka T, Igeta Y, Saido TC, Sahara N, Mori H
Biochemical and biophysical research communications   211(3) 1015-1022   Jun 1995   [Refereed]
APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain.
Tamaoka A, Odaka A, Ishibashi Y, Usami M, Sahara N, Suzuki N, Nukina N, Mizusawa H, Shoji S, Kanazawa I
The Journal of biological chemistry   269(52) 32721-32724   Dec 1994   [Refereed]
Mori H, Ishii K, Tomiyama T, Furiya Y, Sahara N, Asano S, Endo N, Shirasawa T, Takio K
The Tohoku journal of experimental medicine   174(3) 251-262   Nov 1994   [Refereed]
Tamaoka A, Kondo T, Odaka A, Sahara N, Sawamura N, Ozawa K, Suzuki N, Shoji S, Mori H
Biochemical and biophysical research communications   205(1) 834-842   Nov 1994   [Refereed]
Okadaic acid enhances abnormal phosphorylation on tau proteins.
Furiya Y, Sahara N, Mori H
Neuroscience letters   156(1-2) 67-69   Jun 1993   [Refereed]

Misc

 
ENDO HIRONOBU, ENDO HIRONOBU, SAHARA NARUHIKO, SHIMADA HITOSHI
Clin Neurosci   33(10) 1156-1158   Oct 2015
SHINOTOO HITOSHI, SAHARA NARUHIKO, SHIMADA HITOSHI, ZOREKKU TSUBIGUNYU, IKEUCHI KEN, HANYU HARUO, ISHII KENJI, NISHIOKA KEN'YA, KOGA SHUNSUKE, HIGUCHI MAKOTO, SUHARA TETSUYA
核医学   52(3) 294   Sep 2015
SHINOTOO HITOSHI, SAHARA NARUHIKO, SHIMADA HITOSHI, ZOREKKU TSUBIGUNYU, IKEUCHI KEN, HANYU HARUO, ISHII KENJI, KOGA SHUNSUKE, HIGUCHI MAKOTO, SUHARA TETSUYA
Dement Jpn   29(3) 387   Sep 2015
ISHIKAWA AI, ISHIKAWA AI, SAHARA NARUHIKO, TOKUNAGA MASAKI, TAGUWA HIROYUKI, SHIMADA HITOSHI, HIRANO SHIGEKI, HIRANO SHIGEKI, SHINOTOO HITOSHI, KUWABARA SATOSHI, SUHARA TETSUYA, HIGUCHI MAKOTO
Dement Jpn   29(3) 418   Sep 2015
SAHARA NARUHIKO
Dement Jpn   29(3) 328   Sep 2015