2004年4月
Decrease in cortical benzodiazepine receptors in symptomatic patients with leukoaraiosis - A positron emission tomography study
STROKE
- 巻
- 35
- 号
- 4
- 開始ページ
- 942
- 終了ページ
- 947
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1161/01.STR.0000122624.32167.e0
- 出版者・発行元
- LIPPINCOTT WILLIAMS & WILKINS
Background and Purpose -[C-11] flumazenil (FMZ), a ligand that selectively binds to the central benzodiazepine receptor in the neuronal membrane, is useful for evaluating neuronal viability in a positron emission tomography ( PET) scan. Using this ligand, we investigated whether there was a correlation between neuronal integrity in various brain structures and dementia in patients with leukoaraiosis.
Methods - Twelve patients with extensive leukoaraiosis on magnetic resonance imaging were divided into groups of patients with or without dementia. Based on a 2-compartment, 2-parameter model that included metabolite-corrected arterial input and PET-measured cerebral radioactivity, the distribution volume of FMZ (FMZ-V-d) was calculated in various regions of interest by nonlinear curve fitting. Additionally, tracer kinetic analysis was applied for voxel-by-voxel quantification of FMZ-V-d, and data analysis was performed by statistical parametric mapping.
Results - The presence of dementia was associated with a reduced FMZ-V-d in widespread areas of the cerebral cortex, including the bilateral frontopolar and frontal/insular areas, the left temporo-occipital border areas, and the left marginal cortical areas.
Conclusions - Differences in neuronal integrity in the cerebral cortex might determine whether patients with leukoaraiosis become symptomatic or not.
Methods - Twelve patients with extensive leukoaraiosis on magnetic resonance imaging were divided into groups of patients with or without dementia. Based on a 2-compartment, 2-parameter model that included metabolite-corrected arterial input and PET-measured cerebral radioactivity, the distribution volume of FMZ (FMZ-V-d) was calculated in various regions of interest by nonlinear curve fitting. Additionally, tracer kinetic analysis was applied for voxel-by-voxel quantification of FMZ-V-d, and data analysis was performed by statistical parametric mapping.
Results - The presence of dementia was associated with a reduced FMZ-V-d in widespread areas of the cerebral cortex, including the bilateral frontopolar and frontal/insular areas, the left temporo-occipital border areas, and the left marginal cortical areas.
Conclusions - Differences in neuronal integrity in the cerebral cortex might determine whether patients with leukoaraiosis become symptomatic or not.
- リンク情報
- ID情報
-
- DOI : 10.1161/01.STR.0000122624.32167.e0
- ISSN : 0039-2499
- PubMed ID : 15001785
- Web of Science ID : WOS:000220450400026